Comparative Study of the Influence of Sodium Alginate and Hydroxypropyl Methylcellulose on the Release Profile of Ibuprofen from Subcutaneous Implant Formulations http://www.doi.org/10.26538/tjnpr/v6i11.20
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Abstract
Pharmaceutical implants are small sterile solid dosage forms consisting of a highly potent drug intended to be subcutaneously implanted under the skin by suitable special injector or surgical incision in order to deliver the active ingredient continuously over an extended period of time. The aim of this study was to compare the influence of sodium alginate and hydroxypropyl methylcellulose (HPMC) on the release profile of ibuprofen from subcutaneous implant formulations. The ibuprofen implants were formulated using the solvent casting technique with either sodium alginate or hydroxypropyl methylcellulose as the synthetic polymer. The formulated ibuprofen implants were then cut into appropriate sizes and their physicochemical properties such as thickness/diameter, moisture content, weight uniformity, drug content, swelling index, moisture sorption, drug-excipient interactions as well as in vitro drug release
were evaluated. The ibuprofen implants formulated using either sodium alginate or HPMC had uniform physical characteristics with minimum batch-to-batch variation. The mean diameter/thickness of the implants formulated using either sodium alginate or HPMC ranged from 2.45±0.01 – 2.98±0.01 mm and 2.87±0.01 - 3.01±0.01 mm respectively. The mean percentage drug content values for the ibuprofen subcutaneous implants ranged from 95.68±0.11-98.18±0.12%. The implants had moisture content values ranging from 27.64±0.01– 28.92±0.01%. The implants formulated using HPMC were found to have sustained the rate of drug release from the formulation better than those formulated using sodium alginate. There was a significant difference between the release rates of ibuprofen from implants formulated using HPMC and sodium alginate (P<0.05).
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