Geraniol Attenuates Oxidative Stress and Apoptosis in the Liver and Kidney of Streptozotocin-Induced Diabetic Rats http://www.doi.org/10.26538/tjnpr/v6i10.20
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Abstract
Monoterpenes such as geraniol are known for their pharmacological properties. This study assessed geraniol’s antioxidant, and antiapoptotic potentials on diabetic rat liver and kidney. Male Wistar rats (24) were assigned into four groups of 6 rats per group. Diabetic rats (18) received a single dose of streptozotocin (STZ, 60 mg/kg) intraperitoneally. Animals were classified as control, STZ, STZ+GER (geraniol 200 mg/kg), and STZ+GLI (glibenclamide 5 mg/kg) groups. Treatment lasted 21 days. Blood glucose level was assessed using a glucometer. Superoxide dismutase (SOD), catalase (CAT), and glutathione (GSH) were assayed spectrophotometrically using standard commercial kits. Cytochrome c (Cyt c), caspase 9 (C9), and caspase 3 (C3) expressions in rat liver and kidney were assessed using commercial (ELISA) kits. The glucose level in the blood was elevated in the STZ group. Significant expressions of Cyt c, C9, and C3 and reduced SOD, CAT, and GSH levels were observed in rat liver and kidney of the STZ group. Treatment with geraniol significantly reduced blood glucose levels, Cyt c, C9, and C3 expressions relative to the STZ group. Similarly, antioxidant enzyme activities were significantly increased in the rat liver both in the STZ+GER and STZ+GLI groups. Thus, this study shows that geraniol has antidiabetic, antioxidant, and antiapoptotic effects on the liver and kidneys of streptozotocin-induced diabetic rats.
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