Synthesis, Characterization and Biological Studies of Some New Dinitrone Compounds http://www.doi.org/10.26538/tjnpr/v6i11.14
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Abstract
Nitrone compounds are known to possess antioxidant, anticancer and antibacterial activities. In the present study, different dinitrone derivatives were synthesized by the reaction of substituted benzil with N-(2-hydroxylethylamine) and characterized by elemental analysis, UV, IR, 1HNMR and 13C-NMR. The synthesized compounds showed good activity against Staphylococcus aureus and Escherichia coli. N4 showed the highest antimicrobial activity among all the synthesized compounds, and hence, Minimum Inhibitory Concentration (MIC) was determined for this compound against the gram-positive and gram-negative bacteria. When these compounds were tested for their Median Lethal Dose (LD50), it was noted that they were all moderately toxic.
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