Mangosteen Peel Extract Increases Transforming Growth Factor-Beta in the Wound Healing Process


  • Natasya O. Putri Undergraduate Program, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia
  • Kurnia R. Mujiono Undergraduate Program, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia
  • Andra Rizqiawan Department of Oral and Maxillofacial Surgery, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia


Mangosteen peel extract, Medicine,, Wound healing, TGF-β,, Tooth extraction


Transforming growth factor-beta, obtained from mangosteen peel extract, is one of the natural ingredients that can aid in wound healing. It contains antibacterial and anti-inflammatory properties that help accelerate the inflammatory phase so that the proliferative phase can begin immediately. The anti-inflammatory properties in mangosteen peel can bind to factor-κB receptor activator ligands, which can induce osteoclast formation and bone resorption. This study determined the effect of mangosteen peel extract on transforming growth factor-beta expression after tooth extractions of Wistar rats. Six healthy male Wistar rats weighing 150–200 gm were used in this study. The animals were divided into a control group and a treatment group. Both groups had their teeth extracted, but only the treatment group was given mangosteen peel extract at a dose of 300 mg per-oral, three times a day. Following this, the animals were sacrificed, and a specimen of their mandibles was taken to make immunohistochemical staining using the Novocastra detection system and chromogenic detection. Transforming growth factor- beta expression was calculated by selecting the majority of positive visual fields and observation with the OLYMPUS BX 41 series, DP-70 digital camera, and OLYSIA software. Transforming growth factor-beta expression increased after oral administration of mangosteen peel extract on the extraction wounds of Wistar rats in the treatment group. The results indicate that administration of mangosteen peel extract on the extracted teeth of Wistar rats can increase the expression of transforming growth factor-beta on the third day after extraction.


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How to Cite

O. Putri, N., R. Mujiono, K., & Rizqiawan, A. (2022). Mangosteen Peel Extract Increases Transforming Growth Factor-Beta in the Wound Healing Process: Tropical Journal of Natural Product Research (TJNPR), 6(10), 1660–1662. Retrieved from