Mangosteen Peel Extract Increases Transforming Growth Factor-Beta in the Wound Healing Process
http://www.doi.org/10.26538/tjnpr/v6i10.17
Keywords:
Mangosteen peel extract, Medicine,, Wound healing, TGF-β,, Tooth extractionAbstract
Transforming growth factor-beta, obtained from mangosteen peel extract, is one of the natural ingredients that can aid in wound healing. It contains antibacterial and anti-inflammatory properties that help accelerate the inflammatory phase so that the proliferative phase can begin immediately. The anti-inflammatory properties in mangosteen peel can bind to factor-κB receptor activator ligands, which can induce osteoclast formation and bone resorption. This study determined the effect of mangosteen peel extract on transforming growth factor-beta expression after tooth extractions of Wistar rats. Six healthy male Wistar rats weighing 150–200 gm were used in this study. The animals were divided into a control group and a treatment group. Both groups had their teeth extracted, but only the treatment group was given mangosteen peel extract at a dose of 300 mg per-oral, three times a day. Following this, the animals were sacrificed, and a specimen of their mandibles was taken to make immunohistochemical staining using the Novocastra detection system and chromogenic detection. Transforming growth factor- beta expression was calculated by selecting the majority of positive visual fields and observation with the OLYMPUS BX 41 series, DP-70 digital camera, and OLYSIA software. Transforming growth factor-beta expression increased after oral administration of mangosteen peel extract on the extraction wounds of Wistar rats in the treatment group. The results indicate that administration of mangosteen peel extract on the extracted teeth of Wistar rats can increase the expression of transforming growth factor-beta on the third day after extraction.
References
Rusdy H, Saruksuk ASP, Dalimunte RS, Dohude GA. Effectiveness of betadine (Jatropha multifida L.) stem sap on the wound healing after tooth extraction in Sprague-Dawley rats. Padjadjaran J Dentis. 2021; 33(2):145-152.
Ellis S, Lin EJ, Tartar D. Immunology of wound healing. Current dermatology reports 2018; 7(4):350-8.
Cano SM, Lancel S, Boulanger E, Neviere R. Targeting oxidative stress and mitochondrial dysfunction in the treatment of impaired wound healing: a systematic review. Antioxidants 2018; 7(98):1-14.
Yamakawa S and Hayashida K. Advances in surgical applications of growth factors for wound healing. Burns & trauma 2019; 7.
Baniasadi B and Evrard L. Alveolar ridge preservation after tooth extraction with DFDBA and platelet concentrates: a radiographic retrospective study. The open dent J. 2017; 11:99.
Avila‐Ortiz G, Chambrone L, Vignoletti F. Effect of alveolar ridge preservation interventions following tooth extraction: A systematic review and meta‐analysis. J Clin Periodontol. 2019; 46:195-223.
Putri K, Darsono L, Mandalas H. Anti-inflammatory properties of mangosteen peel extract on the mice gingival inflammation healing process. Padjadjaran Journal of Dentistry 2017; 29(3):190-5.
Hong RH, Liang YM, Pan HS, Cheng ZH, Li YH. Alpha- mangostin suppresses receptor activator nuclear factor-κB ligand-induced osteoclast formation and bone resorption in RAW264. 7 cells by inhibiting the extracellular signal-regulated kinase and c-Jun N-terminal kinase signaling. Pharmacogn Mag. 2018; 14(56):390.
Kasagi S and Chen W. TGF-beta1 on osteoimmunology and the bone component cells. Cell & Biosci. 2013; 3(1):1-7.
Mohamed GA, Al-Abd AM, El-Halawany AM, Abdallah HM, Ibrahim SR. New xanthones and cytotoxic constituents from Garcinia mangostana fruit hulls against human hepatocellular, breast, and colorectal cancer cell lines. J Ethnopharmacol. 2017; 198:302-12.
Yuan J, Wu Y, Lu G. α‑Mangostin suppresses lipopolysaccharide‑induced invasion by inhibiting matrix metalloproteinase‑2/9 and increasing E‑cadherin expression through extracellular signal‑regulated kinase signaling in pancreatic cancer cells. Oncology Letters. 2013; 5(6):1958-64.
Pakyari M, Farrokhi A, Maharlooei MK, Ghahary A. Critical role of transforming growth factor beta in different phases of wound healing. Advances in wound care. 2013; 2(5):215-24.
Xia J, Chen J, Zhang Z, Song P, Tang W, Kokudo N. A map describing the association between effective components of traditional Chinese medicine and signaling pathways in cancer cells in vitro and in vivo. Drug discoveries & therapeutics 2014; 8(4):139-53.
Arango DG and Descoteaux A. Macrophage cytokines: involvement in immunity and infectious diseases. Frontiers in immunol. 2014; 5:491.
Chiquet M, Katsaros C, Kletsas D. Multiple functions of gingival and mucoperiosteal fibroblasts in oral wound healing and repair. Periodontol 2000. 2015; 68(1):21-40.
Lesmana FL, Rizqiawan A, Mulyawan I, Sumarta NP, Kamadjaja DB, Danudiningrat CP, Kei T, Rurus GD, Sativa NA, Fanddhy RA. The Effect of the Application of (Garcinia mangostana L.) towards PDGF-B Expression on Human Gingival Fibroblast Cell Culture After Wound Healing Scratch Test Assay (In-Vitro Study). J Inter Dent and Med Res. 2021; 14(4):1413-18.
Simandjuntak RM, Soesanto R, Permatasari D. The Effect of Mangosteen Rind on Fibroblasts Proliferation in Wound Healing Process Post Tooth Extraction of Rat. Doctoral dissertation, Repository Unair. 2014.
Luthfi M, Yuliati EH, Razak FB, Irmalia WR. The efficacy of okra fruit extract on the expression of transforming growth factor beta 1 in the tooth socket of diabetic Wistar rats. Dental Res J. 2021;18:1-7.
Lestari C, Darwin E, Putra DP, Suharti N. The α-mangostin effect on the quantity of TGF-β1 titer relate to the mandibular bone volume of Rattus novergicus in the periodontitis model. J Pharmacy & Pharmacog Res. 2021; 9(5):609-18.
Rahmaniah R, Yuyuntia Y, Soetikno V, Arozal W, Antarianto RD, Louisa M. Alpha mangostin inhibits hepatic stellate cells activation through TGF-β/Smad and Akt signaling pathways: an in vitro study in LX2. Drug Res. 2018; 68(03):153-8.
Hameedaldeen A, Liu J, Batres A, Graves GS, Graves DT. FOXO1, TGF-β regulation and wound healing. International J mol sci. 2014; 15(9):16257-69.
Published
How to Cite
Issue
Section
License
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
