Effect of a Phytonutrient-Rich Product and Administration Time on Cyanide-Induced Cardiotoxicity doi.org/10.26538/tjnpr/v4i7.9
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Abstract
Exposure to cyanide can cause tachycardia, low heartbeat, and cardiac arrest. Trèvo® is a phytochemical-rich product reported to reduce aging and improve immune system. We investigated the ability of trèvo to mitigate the cardiotoxicity of cyanide in male Wistar rats. Twenty-four animals divided into four groups of six animals per group were used for the experiment. Group I (administered distilled water (orally); group II (administered 5 mg/kg bwt KCN [orally]); group III (administered 5 mg/kg bwt KCN [orally] and 2 mL/kg bwt trèvo [orally] after 5 min of exposure to cyanide); group IV (administered 5 mg/kg bwt KCN [orally] + 2 mL/kg bwt trèvo [orally] after 60 min of exposure to cyanide). Malondialdehyde (MDA), catalase (CAT), superoxide dismutase (SOD), acetylcholinesterase (AChE), cytochrome C oxidase (CCO), as well as p53 were evaluated. KCN caused a significant (P < 0.05) decrease in the activities of CCO, CAT, and SOD, raised the level of p53, AChE, and MDA respectively. Trèvo administered immediately after cyanide exposure suppresses the toxic effect of cyanide to various degrees. Histopathological evaluation shows that KCN did not caused any morphological damage to the heart. It can be summarized that trevo has the potential to reverse the biochemical toxicity of cyanide in the heart. There are still more work to ascertain the level of protection offered by trèvo as an antidote against cyanide poison.
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