Concomitant Administration of Catharanthus roseus Extract Improves Efficacy and Safety by Nullifying Diarrhea-Related Toxicity of Acarbose and Metformin in Wistar Rats
doi.org/10.26538/tjnpr/v4i9.25
Keywords:
Concomitant administration, Diarrhea-related toxicity, Metformin, Acarbose, Catharanthus roseusAbstract
The study conceptualized the sites and mechanisms of action as well as explored the interacting benefits of Catharanthus roseus (C. roseus) against the diarrhea-like toxicity associated with the hypoglycemic activity of acarbose and metformin using experimental rats. The diabetes was induced with alloxan. Diarrhoea was induced with castor oil (1 mL per rat) after 30 min of determining blood glucose levels of the different groups including additional Group VIII which received loperamide (3 mg/kg) serving as positive control. The sugar level was determined using a glucometer; while inhibition percent of faecal count and faecal weight were employed to determine antidiarrheal activity. All medicaments showed significant lowering of blood glucose levels when compared with control alone (P < 0.05) having the combination of extractmetformin-acabose extremely significant (P < 0.01), followed by extract-metformin. Also, significant antidiarrheal activity was shown in all groups treated with C. roseus, with highest percentage inhibition in fecal count 86.72% and fecal weight 89.78% exhibited by extractmetformin-acarbose combination compared to loperamide (86.74% and 81.17%, respectively). The extract of C. roseus enhances hypoglycemic efficacy and safety by significantly nullifying diarrheal-like adverse effects of acarbose and metformin.
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