Pretreatment with Oil Palm Leaf Extracts Confers Protection against Crude Oil Adulterated Food (COAF)
doi.org/10.26538/tjnpr/v4i9.24
Keywords:
Toxicity, Oil Palm Leaf, Adulterated Food, Crude oilAbstract
The medicinal importance of oil palm leaf is attracting attention. The present study explored the role of various solvent extracts of the oil palm leaf in conferring protection in rats consuming crude oil adulterated food. The study comprised the use of forty (40) albino rats assigned randomly to eight (8) groups with five in each group. Rats in the control group (Group 1) served as control and were neither exposed to crude oil contaminated diet nor pre-treated with oil palm leaf extracts. Rats in group 2 were initially maintained on a normal diet. Rats in group 3-7 were pre-treated with 250 mg/kg bodyweight of various solvent extracts (aqueous, methanol, ethanol, acetone, and petroleum ether), while rats in group 8 were pre-treated with 250 mg/kg bodyweight of a blended mixture of (aqueous, methanol, ethanol, acetone, and petroleum ether) extracts of palm leaves. Each treatment was for four weeks. Thereafter, the rats in groups 2-8
were exposed to crude oil contaminated diets (4 mL per 100 g of feed) for another four weeks. The body weight of the rats and biochemical indices: hematological, liver function indices and oxidative stress indicators were determined using standard biochemical protocols. The results showed crude oil-mediated derangement of hematological parameters, liver function indices in addition to increased tissue malondialdehyde and depletion of tissue antioxidants. Pretreatment with oil palm leave extracts, however, reduced the trend in these metabolic derangements. Thus, pretreatment of animals with oil palm leaf extract confers protection against crude oil poisoning.
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