Medicinal Plants used for Complementary and Alternative Cancer Therapy in Katsina State, Northwestern Nigeria doi.org/10.26538/tjnpr/v4i9.21
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Abstract
In Katsina State, Nigeria, medicinal plants are widely used for the management of cancer. The usage is however, poorly documented. In this study an ethnobotanical survey of medicinal plants used for the management of cancer in Katsina State, using semi-structured questionnaire. Descriptive statistics were used to present the data on demographic information of the respondents. Relative Frequency of Citation (RFC) and Use Consensus Value (UCV) were used to analyze the popularity of the cited species. Among the 180 respondents, 159 (88%) were males and 21 (12%) females. The majority of the respondents (32.7%) were between 61-75 years of age. Most of the
respondents (85%) were married. Majority (68%) of the respondents had no formal education, while 123 (68.88%) of the respondents were herbalists. Fifty six (56) medicinal plants distributed in 22 families were documented. Most of the species belong to Fabaceae family with 21 representatives and Diospyros mespiliformis had the highest RFC and UCV of 0.15 and 0.30, respectively, while the least RFC and UCV were seen in Tamarindus indica with 0.09 and 0.18, respectively. Of the 57 species, 46 (81%) were trees and 11 (19%) shrubs. Most of the medications (63%) are prepared as decoction and powder. Some of the cited species are utilized for the same
purpose in different parts of the world and potent anticancer potentials of some of the cited species have since been unravelled. Further studies aimed at scientifically authenticating and isolating compound with anticancer potentials from the documented species would be highly valuable.
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World Health Organisation (WHO), Cancer Key Facts [Online] 2018 [cited 2020 Mar 10]. Available from: https://www.who.int/news-room/fact-sheets/detail/cancer
Ferlay J. Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer 2015; 136:E359–E386.
Osakue J, Stephen A, Sheng-xiang Q. Phytochemical and anticancer studies on ten medicinal plants. Bayero J Pure Appl Sci. 2011; 4:36–39.
Jemal A, Bray F, Melissa M, Farley JME, Ward E, Formain D. Global Cancer Statistics. CA Cancer J Clin. 2011; 16:69- 90.
Kanavos P. The rising burden of cancer in the developing world. Ann Oncol. 2006; 17:15–23.
Adefita FA and Ojikutu RK. Prevalence and trend in cancer in Lagos State, Nigeria. Afr Res Rev. 2009; 3(5):1-15.
Awodele O, Adeyomoye AA, Awodele DF. Cancer distribution pattern in south-western Nigeria. Tanzania J Heal Sci. 2015; 13:1–7.
Desai AG, Ghulam N, Qazi RK, Ganju ME, Jaswant SA, Saxena K, Yashbir SB, Subhash CT. Medicinal plants and cancer chemoprevention. Curr Drug Metab. 2014; 9:581– 591.
Greenwell M and Rahman PKS. Medicinal Plants: Their Use in Anticancer Treatment. Int J Pharm Sci Res. 2015; 6:4103–4112.
Alves-Silva JM, Romane A, Efferth T, Salgueiro L. North African Medicinal plants traditionally used in cancer therapy. Front Pharmacol. 2017; 8:1–24.
Abu-Darwish MS and Efferth T. Medicinal plants from near east for cancer therapy. Front Pharmacol. 2018; 9:1–17.
Ayele TT. A Review on Traditionally used medicinal plants/herbs for cancer therapy in ethiopia: current status, challenge and future perspectives. Org Chem Curr Res. 2018; 07:1-8.
Rick-Léonid NM, CédricSima O, Jean DN, Guy-Roger N, Joseph PO, Felix O, Abessolo LOE. Medicinal plants used in management of cancer and other related diseases in Woleu-Ntem province, Gabon. Eur J Integr Med. 2019; 29:100924.
Kuruppu AI, Paranagama P, Goonasekara CL. Medicinal plants commonly used against cancer in traditional medicine formulae in Sri Lanka. Saudi Pharm J. 2019; 27:565–573.
Freiburghaus F, Kaminsky R, Nkunya MHH. Brun R. Evaluation of African medicinal plants for their in vitro trypanocidal activity. J Ethnopharmacol. 1996; 55:1–11.
Fouche G, Cragg GM, Pillay P, Kolesnikova N, Maharaj VJ, Senabe J. In vitro anticancer screening of South African plants. J Ethnopharmacol. 2008; 119:455–461.
Ochwang’i DO, Kimwele CN, Oduma JA, Gathumbi PK, Mbaria JM, Kiama SG. Medicinal plants used in treatment and management of cancer in Kakamega County, Kenya. J Ethnopharmacol. 2014; 15:1040–1055.
Kooti W. Effective Medicinal Plant in Cancer Treatment, Part 2: Review Study. J Evidence-Based Compl Altern Med. 2017; 22:982–995.
Rezadoost MH, Kumleh HH, Ghasempour A. Cytotoxicity and apoptosis induction in breast cancer, skin cancer and glioblastoma cells by plant extracts. Mol Biol Rep. 2019; doi:10.1007/s11033-019-04970-w
Nigatu T, Daniel S, Endalamaw G, Beyene P, Stina O. Cytotoxicity of selected Ethiopian medicinal plants used in traditional breast cancer treatment against breast-derived cell lines. J Med Plants Res. 2019; 13:188–198.
Kankara SS, Ibrahim MH, Mustafa M, Go R. Ethnobotanical survey of medicinal plants used for traditional maternal healthcare in Katsina state, Nigeria. South Afri J Bot. 2015; 97:165–175.
Byg A and Balslev H. Diversity and use of palms in Zahamena, eastern Madagascar. Biodivers. Conserv. 2001; 10:951–970.
Abubakar IB, Angela NU, Garba AD, Singh D, Malami I, Salihu TS, Aliyu M, Sule MS, Jega SA. Ethnobotanical study of medicinal plants used for cancer treatment in Kebbi State, North West Nigeria. Acta Ecol Sin. 2020; 40(4):306-314.
Malami I, Jagaba NM, Abubakar IB, Aliyu M, Alhassan AM, Waziri PM, Yahaya IZY, Mshelia HM, Mathias SN. Integration of medicinal plants into the traditional system of medicine for the treatment of cancer in Sokoto State, Nigeria. Hel. 2020; 6:e04830.
Afolayan ID, Sulaiman KA, Okunade WT. Ethnobotanical survey of plants used in cancer therapy in Iwo and Ibadan, South-Western Nigeria. J Pharm Pharmacog Res. 2020; 8(5):346-367.
Abubakar IB, Angela NU, Olayiwola FS, Malami I, Aliyu M, Ahmed SJ, Nurudeen QO, Falana MB. AN inventory of medicinal plants used for treatment of cancer in Kwara and Lagos States, Nigeria. Euro. J. Integ. Med. 2020; 34(2020): 101062.
Bourhia M. Ethnopharmacological Survey of Herbal Remedies Used for the Treatment of Cancer in the Greater Casablanca-Morocco. Evidence-Based Compl Altern Med. 2019; 1:1–9.
Ukwubile CA, Odugu JA, Njidda S, Umeokoli BO, Bababe AB, Bingari MS, Angyu AE. Survey of plants used in folk medicine in Bali, Gashaka and Sardauna Local Government Areas of Taraba State for the treatment of cancers. Int J Adv Bio Biomed Res. 2020; 8(4):321-338.
Samouh Y, Lemrani A, Hajar H, Mohamad J, Said, AAH. Ethnopharmacological Study of Herbal Medicines used to treat Cancer in Morocco. J Phytopharm. 2019; 8:135–141.
Voeks RA. Are women reservoirs of traditional plant knowledge? Gender, ethnobotany and globalization in northeast Brazil. Singap. J Trop Geogr. 2007; 28:7–20.
Aliyu D, Abubakar G. An ethno-botanical survey of plants used for management of cancer in north-eastern Nigeria. Pharm Chem J. 2016; 3:31–37.
El Fakir L, Bito V, Zaid A, Alaoui TM. complimentary herbal treatments used in Meknes-Tafilalet Region (Morocco) to manage cancer. Am J Plant Sci. 2019; 10:796–812
Jaradat NA, Al-Ramahi R, Zaid AN, Ayesh OI, Eid AM. Ethnopharmacological survey of herbal remedies used for treatment of various types of cancer and their methods of preparations in the West Bank-Palestine. BMC Compl Altern Med. 2016; 16:1–12.
Yin SY, Wei WC, Jian FY, Yang NS. Therapeutic applications of herbal medicines for cancer patients. Evidbased Compl Altern Med. 2013; 2013:1-15.
Ohnishi S and Takeda H. Herbal medicines for the treatment of cancer chemotherapy-induced side effects. Front Pharmacol. 2015; 6:1–5.
Ashidi JS, Houghtona PJ, Hylandsa TE. Ethnobotanical survey and cytotoxicity testing of plants of South-western Nigeria used to treat cancer, with isolation of cytotoxic constituents from Cajanus cajan Millsp. leaves. J Ethnopharmacol. 2010; 128:501–512.
Peter A, Segun OO, Ogbole EA. Medicinal plants used in the management of cancer among the Ijebus of southwestern Nigeria. J Herb Med. 2018; 14:68–75.
Bahmani M. Survey on ethnobotanical uses of anti-cancer herbs in southern region of Ilam, west Iran. J Biol Res. 2017; 90:19-25.
De Melo JG, Santos AG, De Amorim ELC, Nascimento SCD, De Albuquerque, UP. Medicinal plants used as antitumor agents in Brazil: An ethnobotanical approach. Evid-based Compl Altern Med. 2011; 2011:1-14.
Tuasha N, Petros B, Asfaw Z. Plants used as anticancer agents in the Ethiopian traditional medical practices: A Systematic Review. Evid-based Compl Altern Med. 2018; 2018:1-28.
Singh DK, Luqman S. Lawsonia inermis (L.): A perspective on anticancer potential of Mehndi/Henna. Biomed Res Ther. 2014; 1:112–120.
Calderón ÁI. Screening of Latin American plants forcytotoxic activity. Pharm Biol. 2006; 44:130–140.
Bhatia A, Mishra T, Khullar M. Anticancer potential of aqueous ethanol seed extract of Ziziphus mauritiana against cancer cell lines and Ehrlich ascites carcinoma. Evid-based Compl Altern Med. 2011; 2011:1-11.
Sakthivel KM, Kannan N, Angeline A, Guruvayoorappan C. Anticancer activity of Acacia nilotica (L.) Wild. Ex. Delile subsp. indica against dalton’s ascitic lymphoma induced solid and ascitic tumor model. Asian Pac J Cancer Prev. 2012; 13:3989–3995.
Biseko EZ. In vitro antiproliferative potential of Annona senegalensis Pers. and Allophylus africanus P. Beauv. plant extracts against selected cancer cell lines. J Med Plant Res. 2019; 13:304–311.
Sulaiman SK, Abdulazeez BI, Abubakar B, Abdulhamid A. Umar, L. Medicinal plants used for the management of hepatic ailments in Katsina State, Nigeria. J Med Plants Res. 2018; 12:375–386.