Myrtenal Modulates the Immunoexpression of Cell Proliferative, Angiogenic and Invasive Markers in DMBA-Induced Hamster Oral Carcinogenesis doi.org/10.26538/tjnpr/v4i9.10

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Published: Sep 1, 2020
Keywords:
invasion, angiogenesis, cell proliferation, hamsters, DMBA, Cancer

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Rajamanickam Buddhan
Department of Biochemistry and Biotechnology, Annamalai University, Annamalainagar, Tamil Nadu, India
Shanmugam Manoharan
Department of Biochemistry and Biotechnology, Annamalai University, Annamalainagar, Tamil Nadu, India
Chakkaravarthy Elanchezhiyan
Department of Zoology, Annamalai University, Annamalainagar, Tamil Nadu, India
Radhakrishnan Muralinaidu
Department of Oral Pathology, Rajah Muthiah Dental College, Annamalai University, Annamalainagar, Tamil Nadu, India
Mohan Karthik
Department of Biochemistry and Biotechnology, Annamalai University, Annamalainagar, Tamil Nadu, India

Abstract

Abnormal cell proliferation, invasion, metastasis and angiogenesis are the most prominent features of malignant tumours. The present study evaluated the modulating effect of myrtenal on the immunoexpression pattern of cell proliferative (PCNA and cyclin D1), angiogenic (VEGF) and invasive (MMP-2 and MMP-9) markers in 7,12-dimethylbenz(a)anthracene (DMBA)- induced experimental oral carcinogenesis in golden Syrian hamsters using immunohistochemical assay. Topical application (painting) of 0.5% DMBA (six hamsters), a site specific carcinogen, three times a week for 14 weeks resulted in the formation of tumors in the buccal pouches of
golden Syrian hamsters , which was confirmed by histopathological studies. Buccal mucosa excised from the hamsters treated with DMBA alone (tumour-bearing hamsters) showed abnormal immunoexpression pattern of cell proliferative, angiogenic and invasive markers. Myrtenal administration (230 mg/kg b.w) orally to DMBA treated hamsters significantly downregulated the expression of the above said molecular markers in the chemopreventive phase and considerably decreased the expression pattern in the chemotherapeutic phase. The findings from this study, thus support the anti-cell proliferative, anti-angiogenic, and antiinvasive potential of myrtenal in DMBA-induced hamster buccal pouch carcinoma.

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Buddhan, R., Manoharan, S., Elanchezhiyan, C., Muralinaidu, R., & Karthik, M. (2020). Myrtenal Modulates the Immunoexpression of Cell Proliferative, Angiogenic and Invasive Markers in DMBA-Induced Hamster Oral Carcinogenesis: doi.org/10.26538/tjnpr/v4i9.10. Tropical Journal of Natural Product Research (TJNPR), 4(9), 550-557. https://tjnpr.org/index.php/home/article/view/1130
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Vol. 4 No. 9 (2020): Tropical Journal of Natural Product Research
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Articles
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This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

How to Cite

Buddhan, R., Manoharan, S., Elanchezhiyan, C., Muralinaidu, R., & Karthik, M. (2020). Myrtenal Modulates the Immunoexpression of Cell Proliferative, Angiogenic and Invasive Markers in DMBA-Induced Hamster Oral Carcinogenesis: doi.org/10.26538/tjnpr/v4i9.10. Tropical Journal of Natural Product Research (TJNPR), 4(9), 550-557. https://tjnpr.org/index.php/home/article/view/1130

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