Phytochemical Constituents of Securigera securidaca Seed Extract Using GS-MS and HPLC doi.org/10.26538/tjnpr/v4i9.8

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Published: Sep 1, 2020
Keywords:
Sitosterol, Dodecanedioic acid, Phytochemical, Securigera securidaca

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Hammad K Aldal'in
Department of Medical Support, Al-Balqa Applied University, Al-Karak University College, Al- Karak, Jordan
Ghassab Al-Mazaideh
Department of Chemistry and Chemical Technology, University of Tafila Technical University, Tafila, Jordan
Afaf H. Al-Nadaf
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Mutah University, Alkarak- Jordan
Fuad Al-Rimawi
Chemistry Department, Faculty of Science and Technology, Al-Quds University, Jerusalem, Palestine
Akef T. Afaneh
Department of Chemistry, Faculty of Science, Al-Balqa Applied University, Al-Salt, Jordan
Ali Marashdeh
Department of Chemistry, Faculty of Science, Al-Balqa Applied University, Al-Salt, Jordan
Salih Abu-Lafi
Faculty of Pharmacy, Al-Quds University, P.O. Box 20002, Jerusalem, Palestine
Fadi Alakhras
Department of Chemistry, College of Science, Imam Abdulrahman Bin Faisal University, Dammam Saudi Arabia
Haya Ayyal-Salman
School of Biological Sciences, Universiti Sains Malaysia, Penang, Malaysia
Rasheed MAQ Jamhour
Department of Chemistry and Chemical Technology, Faculty of Science, Tafila Technical University, Tafila, Jordan

Abstract

Securigera securidaca (L.) seeds are used in Jordanian folk medicine to treat several disorders like diabetes and hyperlipidemia. The aim of this study was to evaluate the chemical composition of S. securidaca methanol extract. The methanol extract of S. securidaca seeds obtained from local herbal shop in Jordan was investigated for its phytochemical composition using GC-MS and HPLC instruments. Results showed that the methanol extract has twenty-seven natural compounds which made up 99.5% of the total composition. The HPLC-PDA results of S. securidaca showed many phytochemicals that are mainly composed of aromatics and oxygenated hydrocarbons. Dodecanedioic acid and its derivatives, as well as β-Sitosterol are pharmacologically active components that
have not been reported before in this plant. Three unidentified peaks originated in the GCMS. A further detailed study is needed to investigate their identity. These results provide fine evidence for the ethno-pharmacological use of this plant to treat diabetes and
hyperlipidemia.

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Aldal'in, H. K., Al-Mazaideh, G., Al-Nadaf, A. H., Al-Rimawi, F., Afaneh, A. T., Marashdeh, A., Abu-Lafi, S., Alakhras, F., Ayyal-Salman, H., & Jamhour, R. M. (2020). Phytochemical Constituents of Securigera securidaca Seed Extract Using GS-MS and HPLC: doi.org/10.26538/tjnpr/v4i9.8. Tropical Journal of Natural Product Research (TJNPR), 4(9), 540-544. https://tjnpr.org/index.php/home/article/view/1128
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Vol. 4 No. 9 (2020): Tropical Journal of Natural Product Research
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Articles
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This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

How to Cite

Aldal'in, H. K., Al-Mazaideh, G., Al-Nadaf, A. H., Al-Rimawi, F., Afaneh, A. T., Marashdeh, A., Abu-Lafi, S., Alakhras, F., Ayyal-Salman, H., & Jamhour, R. M. (2020). Phytochemical Constituents of Securigera securidaca Seed Extract Using GS-MS and HPLC: doi.org/10.26538/tjnpr/v4i9.8. Tropical Journal of Natural Product Research (TJNPR), 4(9), 540-544. https://tjnpr.org/index.php/home/article/view/1128

References

Jordan plant red list, Publisher: Royal Botanic Garden, Jordan ©2017 Royal Botanic Garden. 2017. 416 p.

Yoona K, Keogh J, Clifton P. Polyphenols and Glycemic Control. Nutrients. 2016; 8 (1):17-44.

Porchezhian E and Ansari S. Effect of Securigera securidaca on Blood Glucose Levels of Normal and Alloxan-Induced Diabetic Rats. Pharm Biol. 2008; 39(1):62–64.

Azarmiy Y, Zakheri A, Alaf A, Fathiazad F, Fakhrjou A, Andali S, Maaleki D, Babaei, Garjani A. The effect of total extract of Securigera securidaca L. seed on thoracic aorta function in nigh-fat fed rats. Pharm Sci. 2009; 15:83–92.

Zahedi-Asl S, Marahel H, Zaree B. Study of the effect of chloroformic extract of Securigera securidaca on serum glucose level and liver glycogen content of mice. J.Kerman Univ Med Sci. 2005; 12:32–38.

Ali A, Mohamed M, Kamel M, Fouad M, Spring O. Studies on Securigera securidacea (L.) Fabaceae) seeds, an antidiabetic Egyptian folk medicine. Pharmazie. 1998; 53(10):710-715.

Mahdi P, Mohammad E, Ali-Akbar M,Karim P. Tostudythe effects of Securigera securidaca (L.) seed against alloxaninduced hyperglycemia. J Med Plants Res. 2011; 5(14):3188–3191.

Rehman K, Al-Gubory K, Laher I, Akash M. Dietary Polyphenols in the Prevention and Treatment of Diabetes Mellitus. Nutrit. Antioxid. Ther Treat Perspec. 2017;1: 377-395.

Kim J, Ju B, Choi W, Kim S. Hypoglycemic and antihyperlipidemic effect of four Korean medicinal plants in alloxan-induced diabetic rats. Am J Biochem Biotechnol. 006; 2:154-160.

Xiao J, Hogger P. Dietary polyphenols and type 2 diabetes: current insights and future perspectives. Curr Med Chem. 2015; 22(1):23-38.

Lin D, Xiao M, Zhao J, Li Z, Xing B, Li X, Kong M, Li L, Zhang Q, Liu YChen H, Qin W, Wu H, Chen S. An Overview of Plant Phenolic Compounds and Their Importance in Human Nutrition and Management of Type 2 Diabetes. Mol. 2016; 21(10):E1374.

Bahadoran Z, Mirmiran P, Azizi F. Dietary polyphenols as potential nutraceuticals in management of diabetes: a review. J Diabet Metab Disord. 2013; 12:43-51.

Garjani A, Fathiazad F, Zakheri A, Akbari N,Azarmie Y, Fakhrjoo A, And alib S, Maleki-Dizaji N. The effect of total extract of Securigera securidaca L. seeds on serum lipid profiles, antioxidant status, and vascular function in hypercholesterolemic rats. J Ethnopharmacol. 2009;

(3):525-532.

Diabetes Atlas IDF. 5thed. International Diabetes Federation, Brussels, Belgium, 2011

Odhiambo R, Kareru P, Mwangi E, Onyango W.

Antioxidant Activity, Total Phenols, Flavonoids and LCMS Profile of Chamaecri stahildebrandtii (Vatke) Lock and Clerodendrum rotundifolium (Oliv.). Eur J Med Plants. 2018; 26(3):1-11.

Al-Zereini W, Al-Rimawi F, Abu-Lafi S, Alakhras F, AlMazaideh G, Ayyal-Salman H, Jamhour R. Identification and Antibacterial Evaluation of Selected Jordanian Medicinal Plants. Orient J Chem. 2018; 34(5):1-8.

Alizadeh-Fanalou S, Babaei M, Hoseini A, Azadi N, Nazarizadeh A, Shojaii A, Borji M, Malekinejad H, Bahraini E. Effects of Securigera securidaca seed extract in combination with glibenclamide on antioxidant capacity, fibroblast growth factor 21 and insulin resistance in

hyperglycemic rats. J Ethnopharmacol. 2019;11(2):331

Aldal'in H K, Wedian F, Al-Mazaideh G M, Ayyal-Salman H, AL-Rimawi F, Alakhras F, Abu-Lafi S, AL-Nadaf A H. Comparative Analysis of Phytochemical Composition of Ethanolic Extract of Jordanian Silvia officinalis. PJBS. 2020: 23(8):989-994.

Al-Nadaf A H , Seder N J and Abu-Rayyan W. Wound healing; Antimicrobial and Anti-oxidant activity for ordanian Juglans regia L. Unripe Fruits. JIPBS. 2018; 5(3):26-34.

Falodun A, Siraj R and Choudhary M I . GC-MS Insecticidal Leaf essential oil of Pyrenacantha staudtii Hutch and Dalz (Icacinaceae). Trop J Pharm Res. 2009; 82:139-143.

Tofighi Z, Molazem M, Doostdar B, Taban P, Shahverdi A, Samadi N, Yassa N. Antimicrobial Activities of Three Medicinal Plants and Investigation of Flavonoids of Tripleuro spermumdisciforme. Iran J Pharm Res. 2015; 14(1):225-231.

Jaradat N, Abualhasan M, Ali I. Comparison invitro of Antioxidant Activity between Fifteen Campanula Species (Bellflower) from Palestinian Flora. J Appl Pharm Sci. 2015; 5(4):101-106.

Garjani A, Fatemeh F, Arezoo Z, Akbari N A Yadollah A, Ashraf F, Sina A, Nasrin M. The effect of total extract of Securigera securidaca L. seeds on serum lipid profiles, antioxidant status, and vascular function in hypercholesterolemic rats. J Ethnopharmacol. 2009; 126:525–532.

Salinari S, Bertuzzi A, Gandolfi A, Greco A V, Scarfone A, Manco M, Mingrone G. Dodecanedioic Acid Overcomes Metabolic Inflexibility in Type 2 Diabetic Subjects. Am J Physiol Endocrinol Metab. 2006; 291(5):1051-1058.

Kaffarnik H, Mühlfellner G, Mühlfellner O, Schneider J, Hausmann L, Zöfel P, Schubotz R, F Fuchs. Beta-sitosterin in the Treatment of Essential Type II Hyperlipoproteinemias. Fortschr Med. 1977; 95(46):2785- 2787.

Al-Nadaf A H., Bastoni H M and Hamdan D F. Microwave-assisted efficient extraction of phenolics from Juglans regia L.: pellicle; kernel unripe fruits; and leaves in different solvents. Int. J. Green Pharm . 2018; 12(3):182.