Anti-Epileptic Studies of Chamaecrista mimosoides Ethanol Extract doi.org/10.26538/tjnpr/v4i5.4
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Abstract
Plant has been man’s most formidable friend for survival, both as food and medicine since time immemorial. This research work aimed to establish a scientific basis for the use of Chamaecrista mimosoides in traditional medicine as anti-epileptic medication. The study was carried out in two (2) phases. Phase I (Chemical Analysis): The whole plant part of Chamaecrista mimosoides was extracted with ethanol and screened for phytochemicals. Phase II (Pharmacological studies): Acute toxicity study was carried out using Lorke’s method and the antiepileptic activity was evaluated using maximal electroshock-induced seizure test in day-old chicks, pentylenetetrazole (PTZ)- and strychnine-induced seizure in mice. The phytochemical study revealed the presence of saponins, cardiac glycosides, tannins, flavonoids, terpenoids and cardenolides. The intraperitoneal median lethal dose value (LD50) of Chamaecrista mimosoides ethanol extract encoded CME in mice was greater than 5000 mg/kg, indicating the extract is relatively safe. The extract at the experimental doses of 250 and 500 mg/kg body weight protected 100% each, of animals against PTZ-induced convulsion; protected 60% and 80% of mice against death induced by strychnine; but had 0% protection of chicks against Tonic Hindlimb Extension (THLE) phase of the Maximal Electroshock Test (MEST) at p < 0.05.
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