Evaluation of the Toxicity Profile and Antidiabetic Potentials of the Methanol Extracts of Boswellia dalzielii (Frankincense Tree) In Alloxan-Induced Diabetic Rats doi.org/10.26538/tjnpr/v4i5.2
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Abstract
Plants used for the treatment of hypoglycemic and hyperglycemic conditions are of considerable interest to ethno botanical community as they are recognized to contain valuable medicinal properties in different parts of the plant. The present study was aimed at investigating the toxicity and antidiabetic potentials of various parts of Boswellia dalzielii in alloxan-induced diabetic rats. Fresh leaf, stem and root barks of Boswellia dalzielii were air-dried, pulverized and extracted using cold maceration with 85% methanol and concentrated to dryness. Acute toxicity (LD50) of the plant extracts were evaluated using Lorke’s method while their anti-diabetic
efficacy was determined on alloxan-induced diabetic rats. All the extracts were considered safe with oral LD50 greater than 5000 mg/kg in all the three plant extracts while the leaf was relatively safer with intraperitoneal LD50 of 3807.8 mg/kg. The leaf, stem and root extracts significantly (p < 0.05) reduced glycaemia by 70.34%, 57.32%, and 57.04%, respectively as against non-treated diabetic rats and a standard drug (glibenclamide) treated rats with -5.92% and 29.02% glycaemia reduction, respectively. Thus, the leaf extract had a more promising antidiabetic activity when compared with the stem and root barks extracts of Boswellia dalzielii. The antidiabetic effect of the plant in alloxan-induced diabetic rats is likely due to the presence of phytochemicals of medicinal importance.
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