Documentation of Medicinal Plants Used For Managing Cancer in Three Selected Local Government Areas of Ekiti State, Southwestern Nigeria

doi.org/10.26538/tjnpr/v4i4.7

Authors

  • Tayo I. Famojuro Department of Pharmacognosy, Faculty of Pharmacy, University of Ibadan, Ibadan, Nigeria
  • Taiwo O. Elufioye Department of Pharmacognosy, Faculty of Pharmacy, University of Ibadan, Ibadan, Nigeria

Keywords:

Ethnobotany,, Traditional medicine,, Medicinal plants,, Cancer.

Abstract

Available chemotherapy for managing cancer is prone to various side effects and in Africa, majority use herbs for their health challenges. This study was undertaken to document medicinal plants used by both traditional healers and the people of Gbonyin, Moba and Efon local government areas of Ekiti State, Nigeria for managing cancer and cancer related diseases. Information were obtained using semi-structured questionnaire and open interview from respondents made up of herbalist (39.4%), herb seller (15.8%), traditional medicine practitioners (21.1%), birth attendants (7.9%) and others (15.8%). Sixty-eight percent were males while 32% were females with their age ranging from 21 to 70 years.A total of 57 plant species belonging to 53 genera and 38 families were identified. Ninety percent (90%) of the respondents interviewed claimed that their clients reported no side effect. Tree accounted for 38% of the life form mostly collected by the traditional healers and leaves were the most frequently used (33%) plant parts in herbal formulations. The commonest plant species among the recipes given by the respondents according to their Use Mention Index (UMI) were Annona muricata (0.154); Xylopia aethiopica, (0.154), Nauclea lactifolia, (0.115); Plukeneta conophora, (0.115) and Plumbago zeylanica (0.115). The study concludes that medicinal plant in the study areas indicated high potential for cancer drug discovery.

References

WHO. "Cancer Fact Sheet N°297". World Health Organization. February 2018. Retrieved 21 March 2018. https://www.who.int/news-room/fact-sheets/detail/cancer

IARC. International Agency for Research on Cancer (IARC). Latest global cancer data: Cancer burden rises to 18.1 million new cases and 9.6 million cancer deaths in 2018. CA: A Cancer J Clin. 2018; 68:317-386.

Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global Cancer Statistics: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries: Global Cancer Statistics 2018. CA Cancer J Clin. 2018; 68:394–424.

Torre LA, Bray F, Siegel RL, Ferlay J, Lortet-Tieulent J, Jemal A. Global Cancer Statistics. CA: A Cancer J Clin. 2015; 65:87–108.

Islami F, Goding SA, Miller KD, Siegel RL, Fedewa SA, Jacobs EJ, McCullough ML, Patel AV, Ma J, Soerjomataram I, Flanders WD, Brawley OW, Gapstur SM, Jemal A. Proportion and number of cancer cases and deaths attributable to potentially modifiable risk factors in the United States. CA: A Cancer J Clin. 2018; 68:31–54.

Omosa LK, Midiwo JO, Masila VM, Gisacho BM, Munayi R, Chemutai KP, Efferth T. Cytotoxicity of 91 Kenyan indigenous medicinal plants towards human CCRF-CEM leukemia cells. J Ethnopharmacol. 2016; 179:177-196.

Fabio F and Luigi G. Herbal Medicine Today: eCAM. 2007; 4:1:37–40.

WHO. Cancer. World Health Organisation. Archived from the original on 29 December 2010. Retrieved 5 January 2011. https://www.who.int/health-topics/cancer#tab=tab_1

Sonibare MA and Abegunde RB. Ethnobotanical study of medicinal plants used by the Laniba village people in South Western Nigeria. Afr J Pharm Pharmacol. 2012; 6:1726- 1732.

Nwodo J, Ibezim A, Simoben CV, Ntie-Kang F. Exploring cancer therapeutics with natural products from African medicinal plants, Part II: alkaloids, terpenoids and flavonoids. Anti-Cancer Agents Med Chem. 2016; 16:108- 127.

Abubakar MS, Musa AM, Ahmed A, Hussaini IM. The perception and practice of traditional medicine in the treatment of cancer and inflammations by the Hausa and Fulani Tribes of Northern Nigeria. J Ethnopharmacol. 2007; 111:625-629.

Aiyelola A and Bello OA. Ethnobotanical potentials of common herbs in Nigeria: A case study of Enugu State. Educ Res Rev. 2006; 1:16-22.

Soladoye MO, Amusa NA, Raji-Esan SO, Chukwuma EC, Taiwo AA. Ethnobotanical survey of anti-cancer plants in Ogun State, Nigeria. Ann Bio Res. 2010; 1:261–273.

Ngule SI, Sandabe UK, Hassaini IM. Ethnobotanical survey of anti-cancer plants in Askira/Uba Local Government Area of Borno State, Nigeria. Afr J Pharm Pharmacol. 2015; 9:123-130.

Segun PA, Ismail FMD, Ogbole OO, Nahar L, Evans AR, Ajaiyeoba EO, Sarker SD. Acridone alkaloids from the stem bark of Citrus aurantium display selective cytotoxicity against breast, liver, lung and prostate human carcinoma cells. J Ethnopharmacol. 2018; 227:131-138.

National Population Commission (NPC). Federal Republic of Nigeria, 2006. Population and Housing Census, Priority Table Volume IV, Population Distribution by Age and Sex. Abuja: National Population Commission (NPC). 2010.

Andrade-Cetto A, Heinrich M. From the field into the lab: useful approaches to selecting species based on local knowledge. Front Pharmacol. 2011; 2:20.

Cheikhyoussef A, Mapaure I, Martin S. The use of some Indigenous Plants for Medicinal and other Purposes by Local Communities in Namibia with Emphasis on Oshikoto Region: A Review. J Med Plants Stud. 2011; 5:406-419.

Tesfaye H, Sebsebe D, Zemede A. An ethnobotanical study of medicinal plants used by local people in the lowlands of Konta Special Woreda, Southern nations, nationalities and peoples regional state, Ethiopia. J Ethnobiol Ethnomed. 2009; 5:26.

Adebo GM and Alfred SDY. Gender dimension of herbal medicine’s knowledge and practice in Ekiti and Ondo States, Nigeria. J Med Plants Res. 2011; 5:1283-1290.

Ashidi JS, Houghton PJ, Hylands PJ, Efferth T. Ethnobotanical survey and cytotoxicity testing of plants of South-western Nigeria used to treat cancer, with isolation of cytotoxic constituents from Cajanus cajan Millsp. Leaves. J Ethnopharmacol. 2010; 128:501–512.

Mumtaz A, Shahjahan Q, Suresh S, Ramamurthy N. Important medicinal plants with Anti-cancer properties in Mahabubnagar district, Telangana State. Int J Phytother Ethnobot. 2015; 2:30–31.

Ochwangi DO, Kimwele CN, Oduma JA, Gathumbi PK, Mbaria JM, Kiam SG. Medicinal plants used in treatment and management of cancer in Kakamega County, Kenya. J Ethnopharmacol. 2014; 151:1040–1055.

Tamokou JdD, Chouna JR, Fischer-Fodor E, Chereches G, Barbos O, Damian G. Anticancer and Antimicrobial Activities of Some Antioxidant-Rich Cameroonian Medicinal Plants. PLoS ONE. 2013; 82:e55880.

Nguyen TT, Parat MO, Shaw PN, Hewavitharana AK, Hodson MP. Traditional Aboriginal Preparation Alters the Chemical Profile of Carica papaya Leaves and Impacts on Cytotoxicity towards Human Squamous Cell Carcinoma. PLoS ONE. 2016: 11(2):e0147956.

Benarba B and Meddah B. Ethnobotanical study, antifungal activity, phytochemical screening and total phenolic content of Algerian Aristolochia longa. J Intercult. Ethnopharmacol. 2014; 3:15–154.

Jain P and Sharma HP. A potential ethnomedicinal plant Semecarpus anacardium Linn. A review. Int. J Res. Pharm. Chem. 2013; 3:564–572.

Eka P, Nur R, Tuti SS. The breast of anticancer from leaf extract of Annona muricata against cell line in T47d. Int J Res Appl Sci. 2012; 2:1.

Biba VS, Amily A, Sangeetha S, Remani P. Anticancer, antioxidant and antimicrobial activity of Annonaceae Family. WJPPS. 2014; 3:1595-1604.

Minari JB and Okeke U. Chemopreventive effect of Annona muricata on DMBA-induced cell proliferation in the breast tissues of female albino mice. Egypt J Med Hum Genet. 2015; 16:207-286.

Andrade-Cetto A. Ethnobotanical study of the medicinal plants from Tlanchinol, Hidalgo, Mexico. J Ethnopharmacol. 2009; 122:163–171.

Bakarnga-Via I, Jean BH, Patrick VTF, Lauve RYT, Gary- Bobo M, Audrey G, Marcel G, Lucain W, Youssouf S, Pierre MJD, Fabrice FB, Chantal M. Composition and cytotoxic activity of essential oils from Xylopia aethiopica (Dunal) A. Rich and Monodora myristica (Gaertn) growing in Chad and Cameroon. Compl Altern Med. 2014; 14:125.

Engel N, Oppermann C, Falodun A, Kragl U. Proliferative effects of five traditional Nigerian medicinal plant extracts on human breast and bone cancer cell lines. J. Ethnopharmacol. 2011; 137:1003-1010.

Wu Jia-liang, Ma Dan-wei, Wang Ya-nan, Zhang H, He B, Li Q, Zou Zhi-yan, Feng J. Cytotoxicity of essential oil of Chenopodium ambrosioides L. against human breast cancer MCF-7 cells. Trop J Pharm Res. 2013; 12:929- 933.

Sayed MD. Traditional medicine in health care. J Ethnopharmacol. 1980; 2:19-22.

Nath KVS, Rao KNV, David B, Sandhya S, Sudhakar K, Saikumar P, Sudha P, Chaitanya RK. A comprehensive review on Allium cepa. J Adv Pharm Res. 2010; 1:94-100.

Ehsan O, Norhani A, Wan ZS, Abdul RO, Syahida A, Wen BK, Nor AZ, Rudi H, Yin WH. Antioxidant, anti- inflammatory and anticancer activities of methanolic extracts from Jatropha curcas Linn. J Med Plants Res. 2011; 5:49-57.

Falodun A, Sheng-Xiang Q, Parkinson G, Gibbons S. Isolation and characterization of a new anticancer diterpenoid from Jatropha gossypifolia. Pharm Chem J. 2012; 45:636.

Jha M, Sharma V, Ganesh N. In vitro antioxidant and cytotoxicity assay of Pistia Stratiotes L. against B16f1 and B16f10 melanoma cell lines. Chem Phytopot: Health Ener Environ Perspec. 2012; 4:19-23.

Jun Y, Yan M, Jeanne D, Qi C. Antitumor activities of Rauwolfia vomitoria extract and potentiation of carboplatin effects against ovarian cancer. Curr Ther Res. 2013; 75:8– 14.

Lawal RA, Ozaslan MD, Odesanmi OS, Karagoz ID, Kilic IH, Ebuehi OAT. Cytotoxic and antiproliferative activity of Securidaca longepedunculata aqueous extract on Ehrlich ascites carcinoma cells in Swiss albino mice. Int J Appl Res Nat Prod. 2012; 5:4.

Sachin H, Kishor D, Vijay K, Bibhilesh M. Evaluation of anticancer activity of Plumbago zeylanica Linn leaf extract. Int J Biomed Res. 2010; 1:2.

Sathya S, Sudhagar S, Vidhya PM, Bharathi RR, Muthusamy VS, Niranjali DS, Lakshmi BS. 3β-hydroxylup- 20(29)-ene-27,28-dioic acid dimethyl ester, a novel natural product from Plumbago zeylanica inhibits the proliferation and migration of MDA-MB-231 cells. Chem Biol Interact. 2010; 188:412-420.

Sato R, Dang KM, McPherson BG, Brown AC. Anticancer Activity of Guava (Psidium guajava) Extracts. J Compl. Integr Med. 2010; 7:43.

Claudia U, Claudia C, Diana C, Amparo A, Punit K, Alexzander A, Susana F. Petiveria alliacea extracts uses multiple mechanisms to inhibit growth of human and mouse tumoral cells. BMC Compl Altern Med. 2008; 8:60.

John FH, Claudia PU, Maria CC, Tito AS, Luis MP, Diana C, Alexzander A, Susana F. A Petiveria alliacea standardized fraction induces breast adenocarcinoma cell death by modulating glycolytic metabolism. J Ethnopharmacol. 2014; 153:641–649.

Isiaka AO, Nudewhenu OA, Guido F, Alimot-Sadiat OH, AbdulRazaq OO, Akindele OO. Essential oils from the leaves of six medicinal plants of Nigeria. Nat Prod Comm. 2013; 8:243-248.

Adaramoye O, Erguen B, Oyebode O, Nitzsche B, Höpfner M, Jung K, Rabien. Antioxidant, antiangiogenic and antiproliferative activities of root methanol extract of Calliandra portoricensis in human prostate cancer cells. J Integr Med. 2015; 13:185–193.

Gossan DPA, Magid AA, Yao-Kouassi PA, Josse J, Gangloff SC, Morjani H, Voutquenne-Nazabadioko L. Antibacterial and cytotoxic triterpenoids from the roots of Combretum racemosum. Fitoter. 2016; 110:89–95.

Ahmad H, Khan SM, Ghafoor S, Ali N. Ethnobotanical study of upper Siran. J Herbs Spices Med Plants. 2009; 15:86–97.

Kolata G. Tree yields a cancer treatment, but ecological cost may be high. New York Times. 1991; A1: A13.

Khan SM, Page S, Ahmad H, Harper DM. Sustainable utilization and conservation of plant biodiversity in montane ecosystems: the western Himalayas as a case study. Ann Bot. 2013; 112:479–501.

Ogbole OO and Ajaiyeoba EO. Traditional Management of Tuberculosis in Ogun State of Nigeria: The Practice and Ethnobotanical Survey. Afr. J. Tradit. Complement. Altern. Med. 2010; 7:79-84.

Bhat JA, Kumar M, Bussmann RW. Ecological status and traditional knowledge of medicinal plants in Kedarnath Wildlife Sanctuary of Garhwal Himalaya, J Ethnobio Ethnomed. 2013; 9:1.

Moshi MJ, Otieno DF, Weisheit A. Ethnomedicine of the Kagera region, North western Tanzania. Part 3: plants used in traditional medicine in Kikuku village, Muleba district. J Ethnobiol Ethnomed. 2012; 8:14.

Adnan M, Ullah I, Tariq A. Ethnomedicine use in the war affected region of northwest Pakistan. J Ethnobiol Ethnomed. 2014; 10:16.

Verma AK, Kumar M, Bussmann RW. Medicinal plants in an urban environment: the medicinal flora of Banares Hindu University, Varanasi, Uttar Pradesh. J Ethnobiol Ethnomed. 2007; 3:35.

Pal SK and Shukla Y. Herbal medicine: Current status and future. Asian Pac. J. Cancer Prev. 2003; 4:281–288.

Chen S, Wang Z, Huang Y. Ginseng and anticancer drug combination to improve cancer chemotherapy: A critical review. Evid Based Compl Altern Med. 2014; 2014:1-13.

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Published

2020-04-01

How to Cite

I. Famojuro , T., & O. Elufioye, T. (2020). Documentation of Medicinal Plants Used For Managing Cancer in Three Selected Local Government Areas of Ekiti State, Southwestern Nigeria: doi.org/10.26538/tjnpr/v4i4.7. Tropical Journal of Natural Product Research (TJNPR), 4(4), 153–164. Retrieved from https://tjnpr.org/index.php/home/article/view/1064