Formulation and Evaluation of Sunscreen Cream Using Detarium senegalense Oil as Base doi.org/10.26538/tjnpr/v4i4.5
Main Article Content
Abstract
Exposure to solar radiation has the beneficial effects of stimulating the cutaneous synthesis of vitamin D and providing radiant warmth. Unfortunately, when the skin is subjected to excessive radiation in the ultraviolet range, deleterious effects may occur such as acute sunburn or solar erythema. This study aimed to formulate and evaluate sunscreen creams with photo protective
and antioxidant activities using Detarium senegalense oil as a base. Six cream formulations (DC 1 to DC 6) were prepared using fusion method and characterized for pH, rancidity, thermal stability, viscosity, organoleptic tests and antioxidant properties. In-vitro determination of sun protection factor (SPF) by UV-spectrophotometer was carried out on all the formulations. The pH readings of the creams were found to be in the range of 5.40 and 6.80. DC 6 formulation had the highest spreadability factor of 14.22 ± 1.07 mm2g -1 other formulations ranged from 11.45 ± 0.94 to 13.01 ± 1.11 mm2g -1 for DC 1 to DC 5. The formulated creams showed excellent in vitro
sun protection ability with SPF ranging from 11.97 for DC 2 to 15.88 for DC 4. Increase in the concentration of detarium oil in the formulation led to an increase in SPF. Topical application of the sunscreen antioxidant cream formulated with the oils of Detarium senegalense and Citrus sinensis will help protect the skin from damage caused by harmful ultraviolet radiation from the sun, as well as protect the skin from oxidative stress.
Downloads
Article Details
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
How to Cite
References
Singh VK, Ramesh S, Pal K, Anis A, Pradhan DK, Pramanik K. Olive oil-based novel thermo-reversible emulsion hydrogels for controlled delivery applications J Mater Sci Mater Med. 2014; 25:703.
Dubey A and Prabhu P. Formulation and evaluation of stimuli-sensitive hydrogels of timolol maleate and brimonidine tartrate for the treatment of glaucoma. Int J Pharm Invest. 2014; 4(3):112-118.
Cross SE, Innes B, Roberts MS, Tsuzuki T, Robertson TA, McCormick P. Human skin penetration of sunscreen nanoparticles: In-vitro assessment of a novel micronized zinc oxide formulation. Skin Pharmacol Physiol. 2007; 20(3):148–154.
Pawar AP, Gholap AP, Kuchekar AB, Bothiraja C, Mali AJ. Formulation and evaluation of optimized oxybenzone
microsponge gel for topical delivery. J Drug Deliv. 2015; 261068.
Kale S, Sonawane A, Ansari A, Ghoge P, Waje A. Formulation and in-vitro determination of sun protection factor of Ocimum basilicum, Linn. leaf oils sunscreen cream. Int J Pharm Pharm Sci. 2010; 2(4):147–149.
Villa A, Viera MH, Amini S, Huo R, Perez O, Ruiz P. Decrease of ultraviolet A light induced common deletion” in healthy volunteers after oral Polypodium leucotomos extract supplement in a randomized clinical trial. J Am Acad Dermatol. 2010; 62:511-513.
Cho JW, Park K, Kweon GR, Jang BC, Baek WK, Suh MH. Curcumin inhibits the expression of COX-2 in UVB- irradiated human keratinocytes (HaCaT) by inhibiting activation of AP-1: p38 MAP kinase and JNK as potential upstream targets. Exp Mol Med. 2005; 30-37(3):186-192.
Sarruf FD and D’Almeida D. Assessment of in-vitro Sun Protection Factor (SPF) and rheological profile of commercial infant’s sunscreens. J Basic Appl Pharm Sci. 2013; 34(1):33-36.
Sowemimo AA, Pendota C, Okoh B, Omotosho T, Idika N, Adekunle AA, Afolayan AJ. Chemical composition, antimicrobial activity, proximate analysis and mineral content of the seed of Detarium senegalense JF Gmelin. Afr J Biotechnol. 2011; 10(48):9875-9879.
Akah P, Nworu C, Mbaoji F, Nwabunike I, Onyeto C. Genus Detarium: Ethnomedicinal, phytochemical and pharmacological profile. Phytopharmacol. 2012; 3(2):367- 375.
Cisse M, Dieme O, Diop N, Dornier M, Ndiaye A, Sock O. Le ditax (Detarium senegalense): principals caractéristiques et utilisations au Sénégal fruits. Fruits 2010; 65(05):293 – 306.
Naidu KA. Vitamin C in human health and disease is still a mystery? An overview. Nutr J. 2003; 2:7.
Malavolta M and Mocchegiani E. Molecular Basis of Nutrition and Aging. Academic Press. 2016. 735-758 p.
Quality assurance of pharmaceuticals: a compendium of guidelines and related materials. Vol. 2, Good manufacturing practices and inspection. – 2nd ed. pp 67-84
El Omari N, Sayah K, Fettach S, El Blidi O, Bouyahya A, Faouzi M, Kamal R, Barkiyou M. Evaluation of In Vitro Antioxidant and Antidiabetic Activities of Aristolochia longa Extracts. Evid based Compl Altern Med. eCAM, 2019; 7384735. https://doi.org/10.1155/2019/7384735
Ilomuanya M, Akhimien T, Aghaizu C, Adeyinka O, Ajayi T. Polyherbal Antioxidant Topical Preparation Comprising Ethanol Extract of Tetracarpidium conophorum and Ocimum gratissimum: Formulation and Evaluation. Dhaka Univ J Pharm Sci. 2018; 17(2):213-219.
Ilomuanya MO, Elesho RF, Amenaghawon AN. Development of trigger sensitive hyaluronic acid/palm oil- based organogel for in vitro release of HIV/AIDS microbicides using artificial neural networks. Future J Pharm Sci. 2020; 6:1.