Platinum-Based Anticancer Chemotherapy Tissue Toxicity: The Use of Carrot and Tomato Supplements as a Dietary Intervention in Rattus norvegicus doi.org/10.26538/tjnpr/v4i10.18

Abstract

High-dose of cisplatin therapy is limited due to its cumulative toxicity. Recently, diverse natural product and dietary compounds have been exploited as potential protective agents against cisplatin-induced tissue toxicity. This paper aims to examine the effect of a supplementary diet of carrot and tomato against cisplatin-induced dyslipidemia and hepatic transaminase changes and the risk of cardiovascular diseases in male Wistar rats. Male albino rats weighing (98.4+2.4g) were randomly assigned into five groups (n=6). Group one served as control and was maintained on a control diet for 7days. Rats of groups 2, 3, 4, and 5 were injected a single dose of cisplatin (7.5mg/kg/body weight) and thereafter fed with a control diet, 5% carrot, 5% tomato, and 5% tomato + 5%carrot supplemented diet respectively. The result revealed that cisplatin caused bodyweight loss, increases the plasma total cholesterol,
triglyceride, LDL, AST, ALP, and ALT level significantly. Conversely, it causes a decrease in the plasma HDL cholesterol level. However, supplementation with tomato and carrot causes a decrease in the plasma level of total cholesterol, triglyceride, LDL AST, ALP, and ALT level towards normal (control). Additionally, the atherogenic parameters were observed to be slightly high upon cisplatin injection whereas treatment with tomato and carrot significantly reduced the atherogenic parameters towards normal (control). These findings suggest the positive effects of tomato and carrot supplementation against cisplatin-induced dyslipidemia, hepatotoxicity, and risk of cardiovascular diseases. Accordingly, carrot and tomato supplementation might serve as unique supplements that can be used in
conjunction with cisplatin chemotherapy.