Antioxidant and Hepatoprotective Potentials of Methanol Extract of Ficus platyphylla Stem Bark (Moraceae) in Wistar Rats doi.org/10.26538/tjnpr/v4i3.6
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Abstract
Ficus platyphylla Delile has been used in Nigerian traditional medicine for the management of pain, epilepsy and inflammation. The aim of this study is to evaluate the antioxidant and hepatoprotective potentials of methanol extract of F. platyphylla stem bark in Wistar rats. The hepatoprotective properties of methanol extract of F. platyphylla stem bark was tested both in vitro and in vivo by evaluating oxidative stress markers, liver function parameters and changes in the morphology of liver in carbon tetrachloride (CCl4) induced hepatotoxicity in Wistar rats. In vitro antioxidant studies of methanol extract of F. platyphylla stem bark was evaluated using 2, 2-diphenyl-2-picryhydrazyl (DPPH) model. Treatment of Wistar rats-induced hepatotoxicity with CCl4 with methanol extract of F. platyphylla stem bark at 100, 200 and 400 mg/kg revealed significant decrease in in vivo stress markers levels (p < 0.05, p < 0.001). Methanol extract of F. platyphylla stems bark at doses of 100 mg/kg and 400 mg/kg significantly reversed the increasing transaminases activities induced by the CCl4 toxicity (p < 0.05) in the Wistar rats. Histologically, there were differences in the liver morphology as compared to the control and silymarin group. These results provide scientific evidence that the liver pathology in CCl4 induced hepatotoxicity is improved by methanol extract of F. platyphylla stem bark.
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