Preliminary Studies on the Anti-Inflammatory and Analgesic Effects of Methanol Leaf Extract of Ficus asperifolia Miq doi.org/10.26538/tjnpr/v4i3.5
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Abstract
Ficus asperifolia is used traditionally in most African countries for the treatment of inflammatory diseases, pain, tumours and infertility. This study was carried out to evaluate the anti-inflammatory and analgesic properties of methanol leaf extract of Ficus asperifolia in rodents. The extract was subjected to phytochemical and acute toxicity tests. Anti-inflammatory (using carrageenan-induced paw oedema test) and analgesic studies (using acetic acid-induced writhing, hot plate and formalin tests) were conducted on the extract at doses of 250, 500 and 1000 mg/kg. The intraperitoneal median lethal dose of Ficus asperifolia was estimated to be 3800 mg/kg in mice. The extract at all the tested doses significantly (p<0.05) decreased the mean paw oedema induced by carrageenan when compared to control. It also offered 20.98% inhibition of writhing behaviour above piroxicam (positive control) at 1000 mg/kg. In the hot plate test, Ficus asperifolia extract significantly (p<0.05) increased the mean reaction time at all the tested doses. Similarly, the extract significantly (p<0.05) reduced the paw licking time in both phases of the formalin test with a peak activity (>50% inhibition of pain) at 1000 mg/kg. In conclusion, the results obtained revealed that methanol leaf extract of Ficus asperifolia possesses anti-inflammatory and analgesic properties.
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