Antihypertensive Effects of TCT: "Thanh Can Thang", a Vietnamese Tradition Medicine Remedy, in a Cortisone Acetate Rat Model doi.org/10.26538/tjnpr/v4i10.13
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Abstract
"Thanh Can Thang" (TCT) has been used in Vietnamese traditional medicine to treat clinical hypertension. The remedy contains 10 medicinal herbs, including Ramulus cum Unco Uncariae, Radix Scutellariae, Flos Chrysanthemi indici, Herba Loranthi Gracifilolii, Achyranthes bidentata Blume, Dipsacus japonicas, Alisma orientalis, Ligusticum wallichii, Fossilia Ossis Mastodi, and Zizyphus jujube. This study aimed to investigate the in vivo anti-hypertensive effects of TCT in Wistar rats, using a cortisone acetate model. Hypertension was induced with daily subcutaneous administration of 2.5 mg/kg/day cortisone acetate and 1% sodium chloride in
drinking water for 28 days. Two different doses of TCT (14.56 and 43.68 g/kg/day) were used. TCT treatment at both doses resulted in significant decrease in systolic, diastolic, and average blood pressure values. Interestingly, 24 h after the last administration of cortisone acetate, both tested TCT doses were able to restore the levels of systolic, diastolic, and average blood pressure
values back to the levels observed in the control group, hence ameliorating hypertension induced by cortisone acetate. This study verifies the usefulness of the traditional medicine TCT in hypertension treatment.
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