Anticancer Activity of Hispidulin from Saussurea simpsoniana and Lupeol from Vincetoxicum arnottianum doi.org/10.26538/tjnpr/v4i2.2

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Published: Feb 1, 2020
Keywords:
Antiasthmatic herbs,, Isolation,, Antitumor activity, Metabolic viability assay

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Ghulam Hassan
Department of Chemistry, Karakoram International University, 15100-Gilgit, Gilgit-Baltistan, Pakistan
Qandeel Zahra
Department of Chemistry, Karakoram International University, 15100-Gilgit, Gilgit-Baltistan, Pakistan
Iftikhar Ali
Department of Chemistry, Karakoram International University, 15100-Gilgit, Gilgit-Baltistan, Pakistan
Nadja Engel
Department of Oral and Maxillofacial Surgery, Facial Plastic Surgery, Rostock University Medical Center, Schillingallee 35, 18057 Rostock, Germany
Kiran Ali
HEJ Research Institute of Chemistry, University of Karachi, Karachi-75270, Pakistan
Gul Bahreen
Department of Chemistry, Karakoram International University, 15100-Gilgit, Gilgit-Baltistan, Pakistan.
Viqar Uddin Ahmad
HEJ Research Institute of Chemistry, University of Karachi, Karachi-75270, Pakistan.
Shahid Aziz
Shandong Key Laboratory of TCM Quality Control Technology, Shandong Analysis and Test Center, Jinan, Shandong Province (250014), P.R. China.
Daijie Wang
Shandong Key Laboratory of TCM Quality Control Technology, Shandong Analysis and Test Center, Jinan, Shandong Province (250014), P.R. China.

Abstract

Saussurea simpsoniana (Field & Gard.) Lipsch (Asteraceae) is a herb, locally known as Boshi Phonar in Gilgit, Pakistan. This herb is used for the treatment of asthma, cough, pneumonia, fever, snakebite, and dysmenorrhoea. The plant Vincetoxicum arnottianum (Wight) Wight (Syn: Cyanchum arnottianum Wight), (Apocynaceae) is used for the treatment of asthma, gastritis, malaria, cholera, skin diseases, wounds, ulcer and constipation. It has recently been reported for its antitumor activity. The present study was aimed to evaluate the methanol extracts of the plants species; S. simpsoniana and V. arnottianum for isolation of the phytoconstituents. As a result of our study, β-sitosterol, hispidulin and β-sitosterol-β-D-glucoside were isolated and characterized from S. simpsoniana. While β-sitosterol, β-sitosterol-β-D-glucoside, and lupeol were isolated and characterized from V. arnottianum. Hispidulin and lupeol were tested against breast cancer MCF-7, osteosarcoma MG-63, pancreatic PACA-44, and alveolar rhabdomyosarcoma Rh30 cell lines and hispidulin showed a moderate reduction of cell viability in the range of 20 to 50%.

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How to Cite
Hassan, G., Zahra, Q., Ali, I., Engel, N., Ali, K., Bahreen, G., Uddin Ahmad, V., Aziz, S., & Wang, D. (2020). Anticancer Activity of Hispidulin from Saussurea simpsoniana and Lupeol from Vincetoxicum arnottianum: doi.org/10.26538/tjnpr/v4i2.2. Tropical Journal of Natural Product Research (TJNPR), 4(2), 31-35. https://tjnpr.org/index.php/home/article/view/1011
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Vol. 4 No. 2 (2020): Tropical Journal of Natural Product Research
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