Antimalarial Activity of the Methanol Aerial Extract of Alysicarpus glumaceus (Vahl) DC. in Plasmodium berghei Infected Mice
doi.org/10.26538/tjnpr/v3i3.3
Keywords:
Alysicarpus glumaceus, Antimalarial,, Acute toxicity,, Chemosuppression, Plasmodium bergheiAbstract
Medicinal plants are a potential source of affordable and effective drugs used in the treatment of many diseases. The plant Alysicarpus glumaceus has been used in traditional medicine for the treatment of many ailments including; thrush, sore, asthma, burn, and fever. The present study was designed to investigate the antimalarial activity of the methanol aerial extract of Alysicarpus glumaceus in Plasmodium berghei infected mice using suppressive, curative and prophylactic models. Phytochemical screening using standard procedures and acute toxicity studies via the oral route in mice were also conducted. Results from the phytochemical screening revealed the presence of glycosides, saponins, tannins, flavonoids, triterpenes, and alkaloids. The oral mean lethal dose (LD50) was estimated to be greater than 5,000 mg/kg in mice. The methanol aerial extract of Alysicarpus glumaceus at doses of 250, 500 and 1,000 mg/kg produced a significant (p<0.05) dose-dependentchemosuppression in the suppressive, curative and prophylactic tests respectively. There was a statistically significantly (p<0.05) prolongation of mean survival time in the extract treated mice in the curative study. The results of this investigation suggest that the methanol aerial extract of Alysicarpus glumaceus contains bioactive constituents with antimalarial activity
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