Effect of Ethanol Extract of Amaranthus Viridis (Inine) on Potassium-Bromide-Induced Haematoxicity in Wistar Rats Tropical Journal of Natural Product Research
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Abstract
Potassium Bromate (KBrO3) is an oxidative agent capable of causing hematological alterations and other toxic effects. Amaranthus Viridis (Inine) is a medicinal plant traditionally used for various therapeutic purposes. This study investigated the ameliorative effect of ethanol extract of Amaranthus viridis (Inine) on the haematological parameters in potassium bromate (KBrO3) intoxicated Albino Rats. Thirty (30) rats divided into six (6) groups consisting of five rats each, group one as the normal control, group two as the negative control (50 mg/kg of KBrO3 only), group three Vitamin C (100 mg/kg) + 50 mg/kg of KBrO3and group four to six (200 mg/kg, 400 mg/kg, and 800 mg/kg) respectively. KBrO3 exposure significantly altered some haematological indices in the rats indicating a haematotoxic effects. The results showed a dose-dependent improvement in several haematological parameters upon coadministration of Amaranthis viridis occurred. The red blood cell count (RBC), packed cell volume (PCV), haemoglobin concentration (Hb), and white blood cell count (WBC) exhibited notable recovery in comparison to the KBrO3-treated group. Platelet count (PLT), mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), and mean corpuscular hemoglobin concentration (MCHC) also demonstrated positive alterations in response to the extract. The group receiving the highest dose of the leaf extract (800 mg/kg) alongside KBrO3 displayed the most significant improvement in the aforementioned parameters, indicating a potential dose-dependent protective effect against KBrO3-induced haematotoxicity. These findings suggest the potential therapeutic efficacy of Amaranthus viridis extract in mitigating KBrO3-induced hematological alterations.
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