Effect of Garcinia mangostana Linn Extract on Systolic Blood Pressure and Inflammation in Hypertensives: A Systematic Review and Meta-Analysis
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Abstract
The potential of Garcinia mangostana Linn Extract (GMLE) in managing hypertension has garnered increased interest, although its effects are not yet fully understood. This meta-analysis aimed to evaluate the efficacy of the GMLE in reducing systolic blood pressure (SBP) and inflammation. A systematic search of PubMed, Google Scholar, and Science Direct was conducted in April 2024, including randomized controlled trials (RCTs) and cohort studies that compared the GMLE to a placebo. The analysis included 299 participants from three RCTs and one cohort study. The results indicated that, compared with the placebo, the GMLE significantly reduced SBP (SMD = -1.25, p = 0.003, I² = 69%). Additionally, GMLE was associated with significant decreases in inflammatory markers, including high-sensitivity C-reactive protein (hs-CRP) (SMD = -5.09, p = 0.03), interleukin-1 (IL-1) (SMD = -1.04, p < 0.00001), and interleukin-6 (IL-6) (SMD = -1.05, p < 0.00001). In conclusion, GMLE appears to be an effective option for managing hypertension and may offer a safer, more economical alternative to conventional treatments.
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