Anti-inflammatory, Analgesic, and Motor Improvement Effects of Bee Venom Acupuncture on Freund’s Complete Adjuvant-Induced Spinal Degeneration in Rats
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Abstract
Spinal degeneration (SD) is a common condition among the elderly, causing pain and reduced mobility. Prompt detection, monitoring, and treatment of degenerative conditions is crucial to minimize serious complications. In this experiment, rats with Freund’s complete adjuvant (CFA)-induced SD received bee venom acupuncture (BVA) at doses of 0.5, 1.0, and 1.5 mg/kg or Mobic (meloxicam) acupuncture (MA) at 1.0 mg/kg. All treatments were administered twice weekly for three weeks. The anti-inflammatory, analgesic, and motor improvement effects of BVA were evaluated via behavioral tests, white blood cell counts, and histological analysis. Results showed significant reductions in white blood cell count and the inflammatory marker interleukin-1β (IL-1β) in both BVA and MA groups compared to the control SD group. Additionally, the BVA and MA treatment groups showed increased hotplate paw-withdrawal latency, indicating reduced pain sensitivity, and longer times on the accelerating rotarod, indicating improved motor function, compared to the control group. These findings suggest that BVA has promising anti-inflammatory, analgesic, and motor-improving effects for the symptomatic treatment of SD.
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