Anti-hyperlipidemic Effect of Camellia hakodae Ninh Extract in an In Vivo Rat Model
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Abstract
Vietnamese yellow tea, Camellia hakodae Ninh (Theaceae), is an endemic species in Vietnam. Its neutral properties and sweet taste is readily harnessed in traditional Vietnamese medicine for the management of heart, kidney, and liver problems. Yellow tea is known to lower blood pressure and lipids but the anti-hyperlipidemic effect of C. hakodae has not been studied. This study aimed to assess the blood lipid-lowering effects of the dry extract of C. hakodae leaves (CKL-THV) in rats. Wistar rats were induced with exogenous hyperlipidemia using a cholesterol-rich diet and then administered CKL-THV continuously for 4 weeks. The study evaluated the effects of CKL-THV on lipid profiles and the atherogenic index of plasma (AIP). Results indicated that CKL-THV at doses of 0.35 and 1.05 g/kg/day effectively reduced total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C) indices compared to the model group after both 2 and 4 weeks. Notably, CKL-THV at a dose of 1.05 g/kg/day significantly (p < 0.05) increased HDL-C level compared to the model group. Both doses of CKL-THV significantly lowered the AIP compared to the model group (p < 0.05). CKL-THV demonstrated the ability to regulate blood lipid indices and reduce the AIP in a rat model of exogenous hyperlipidemia. These findings suggest that CKL-THV holds potential as an anti-hyperlipidemic agent.
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