Studies on the Effect of Musa paradisiaca on the Morphology and Microanatomy of Some Female Reproductive Organs of Animal Model
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Abstract
Musa paradisiaca, a staple food abundant in Vitamins C and E, exhibits antioxidant properties and has been traditionally employed in managing reproductive health concerns. This study aimed to evaluate the impact of Musa paradisiaca aqueous extract on body weight and ovarian histomorphology in Wistar rats. Thirty adult female Wistar rats (100-150 g) were randomly divided into three groups (n=10). Group I received standard rat feed and water, Group II received a low dose of Musa paradisiaca (200 mg/kg BW), and Group III received a high dose of Musa paradisiaca (400 mg/kg BW). Extracts were administered daily via oral gavage for 21 days. Twenty-four hours after the last dose, animals were sacrificed, and the ovaries and fallopian tubes were harvested for histomorphological analysis. The results reveal a significant increase in body weight of the treated animals. Histomorphological observations showed positive effects on ovarian tissue, especially in the treated groups, revealing an improved tunica albuginea layer, increased developing follicles, and enhanced follicular and granulosa cellular architecture, while the fallopian tube showed slightly branched tubal mucosal folds, moderate and thickened epithelial layers with remarkable epithelial cell hyperplasia and condensed connective tissue stoma.
This study suggests that Musa paradisiaca may improve ovarian and fallopian cellular activities, improving female rats' overall reproductive health.
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Mascarenhas MN, Flaxman SR, Boerma T, Vanderpoel S, Stevens GA. National, regional, and global trends in infertility prevalence since 1990: a systematic analysis of 277 health surveys. PLoS Med. 2012;9(12):e1001356. doi: 10.1371/journal.pmed.1001356.
Ajithkumar NJ, Bharathi DR, Kousar H, Siddiq A, Nataraj GR, Bagalkot S. Musa paradisiaca-A Review on Traditional uses and Pharmacological Activities. RGUHS J. Pharm. Sci. 2017;7(2): 20-23
Alabi AS, Omotoso GO, Tagoe CN, Akinola OB, Enaibe BU. Effects of unripe Musa Paradisiaca on the histochemistry of the testis and testosterone levels in adult albino rats. Niger. J. Physiol. Sci. 2017;32(1):105-108
Alhalabi N, Alhalabi MM, Alsamawi S, Alhalabi M. Ovulation stigma and rupture of ovarian tunica albuginea in a patient with polycystic ovary syndrome (video). J. Surg. Case Rep. 2021;10, 1–2
Al-Shwafi T, Alhazmi M, Alnazer M, & Tashkandi M. A Review on Phytochemical and Pharmacological Properties of Musa paradisiaca. Plants. 2021;10(10), 1972.
Dun EC & Nezhat CH. Tubal factor infertility: diagnosis and management in the era of assisted reproductive technology. Obstet Gynecol Clin North Am. 2012;39(4):551-66.
Briley SM, Jasti S, McCracken JM, Hornick JE, Fegley B, Pritchard MT, Duncan FE. Reproductive age-associated fibrosis in the stroma of the mammalian ovary. Reproduction (Cambridge, England). 2016; 152 (3):245-260.
Briley SM, Jasti S, McCracken JM, Hornick JE, Fegley B, Pritchard MT, Duncan FE. Reproductive age-associated fibrosis in the stroma of the mammalian ovary. Reproduction (Cambridge, England). 2016; 152 (3):245-260.
Weiss G, Goldsmith LT, Taylor RN, Bellet D, Taylor HS. Inflammation in reproductive disorders. Reprod Sci. 2009;16(2):216-29
Desai R and Tranesh G. Ovary Histology: In Osmosis. 2022. Available from https://www.osmosis.org/learn/ovary_histology.
Galani V. Musa paradisiaca Linn.-A Comprehensive Review. Sch Int J Tradit Complement Med. 2019:45-56.
Gilbert SF. Oogenesis: In Developmental Biology, 6th Edition. Sinauer Associates. NCBI, NIM. 2000.
Gomes A, Ghosh S, Sengupta J, Datta P, Gomes A. Herbonanoceuticals: a new step towards herbal therapeutics. Med Aromat Plants. 2014;3(3):162.
Huang C, Ogawa R. The vascular involvement in soft tissue fibrosis—lessons learned from pathological scarring. Int J Mol Sci. 2020;21(7):2542.
Iroaganachi M, Eleazu CO, Okafor PN, Nwaohu N. Effect of unripe plantain (Musa paradisiaca) and ginger (Zingiber officinale) on blood glucose, body weight and feed intake of streptozotocin-induced diabetic rats. Open Biochem. J. 2015; 9, 1-6. DOI: 10.2174/1874091X01509010001
Khare CP. Indian Medicinal Plants Springer-Verlag Berlin; 2007. 52-53. https://doi.org/10.1007/978-0-387-70638-2_1717
Krieg T, Abraham D, Lafyatis R. Fibrosis in connective tissue disease: the role of the myofibroblast and fibroblast-epithelial cell interactions. Arthritis Res Ther. 2007;9:1-7. doi.10.1186/ar2188.
Eddy CA & Pauerstein CJ. Anatomy and physiology of the fallopian tube. Clin Obstet Gynecol. 1980;23(4):1177-93.
Landry DA, Yakubovich E, Cook DP, Fasih S, Upham J, Vanderhyden BC. Metformin prevents age-associated ovarian fibrosis by modulating the immune landscape in female mice. Sci. Adv. 2022;8(35). doi.10.1126/sciadv.abq1475.
Landry DA, Yakubovich E, Cook DP, Fasih S, Upham J, Vanderhyden BC. Metformin prevents age-associated ovarian fibrosis by modulating the immune landscape in female mice. Sci. Adv. 2022;8(35). doi.10.1126/sciadv.abq1475
Rezvani M, Shaaban AM. Fallopian tube disease in the nonpregnant patient. Radiographics. 2011;31(2):527-48.
Mayes MD. Endothelium and Endothelin Antagonists in Systematic Rheumatic Disease. Arthritis Rheumatoid. 2003; 48:1190-1199. doi.10.1002/art.10895.
Mayo Clinic Ovarian Cancer. 2018. https://www.mayoclinic.org/diseases-conditions/ovarian-cancer/symptoms-causes/sc-20375941
Mescher AL. (2015) Ovary: In Junqueura's Basic Histology. Text and Atlas, 14th Edition. Churchill Livingstone. 2015. ISBN-13: 978-007842709.
Kalita P, Chakraborty A. Effect of Clerodendrum infortunatum on testicular tissue in streptozotocin-induced diabetes rats. Int. J. Pharm. Sci. Res. 2015;6(4):1650.
Shakya AK. Medicinal plants: Future source of new drugs. Int. J. Herb. Med. 2016;4(4):59-64.
Varanasi LC, Subasinghe A, Jayasinghe YL, Callegari ET, Garland SM, Gorelik A, Wark JD. Polycystic ovarian syndrome: Prevalence and impact on the wellbeing of Australian women aged 16–29 years. Aust. N. Z. Obstet. Gynaecol. 2018;58(2):222-233. doi.10.1111/ajo.12730.
Chakma J. Effect of Mode of Herbal Formulation Supplementation on Productive and Reproductive Performance of Post-Partum Crossbred Cows (Doctoral dissertation, Indian Veterinary Research Institute). 2023
Ghosh AK, Quaggin SE, Vaughan DE. Molecular basis of organ fibrosis: potential therapeutic approaches. Exp. Biol. Med. 2013;238(5):461-81.
Rudra S, Tahamina A, Emon NU, Adnan M, Shakil M, Chowdhury MH, Barlow JW, Alwahibi MS, Soliman Elshikh M, Faruque MO, Uddin SB. Evaluation of various solvent extracts of Tetrastigma leucostaphylum (Dennst.) Alston leaves, a Bangladeshi traditional medicine used for the treatment of Diarrhea. Molecules. 2020;25(21):4994.