Production and Characterisation of Microencapsulated Particles of Harugana madagascariensis: a Natural Fungicide with an Improved Delivery Potential

Main Article Content

Adedokun Oluwasegun
Igboeli Kosisochukwu
Ogochukwu Ume
Aiseosa Igharo
Ibrahim Kehinde
Ibiwumi Adedeji
Onome Adeboye
Nnamani Didacus

Abstract

Invasive fungal infections (IFI) are caused by non-pathogenic fungi in the immunocompromised host. However, ethnobotanical information suggests that Harugana madagascariensis (HM-E) is one of the medicinal plants used to treat IFI in Southern Nigeria. This study aimed at evaluating the effect of HM-E and microencapsulated extract of H. madagascariensis (HM-M) on Aspergillus niger and Rhizopus spp as well as the influence of microencapsulation on the biological activity of HM-E. The microencapsulation was done using a modified coacervation process, antifungal screening was carried out using an agar disc model, characterization of the microparticles was done using Fourier-transform infrared (FTIR), Scanning electron microscopy (SEM), and Energy Dispersive X-ray (EDX). The encapsulation efficiency of HM-M was observed to be 72.45 with a solubility value of 97.95%. SEM showed that HM-M particles exhibited relatively similar sizes, an irregular surface structure, and deep depressions in the walls. EDX analysis of HM-E at spot 1 revealed the presence of oxygen and carbon. Also, A. niger was resistant to HM- E and HM-M at 0.2 and 0.4 mg/mL, while no growth of Rhizopus spp was observed with HM-E and HM-M at 0.2 and 0.4 mg/mL in a concentration-dependent manner. In conclusion, Rhizopus sp was observed to be sensitive to HM-E and HM-M at both 0.2 and 0.4 mg/mL, in a concentration-dependent manner. The findings support the usage of HM and encourage microencapsulation of HM to improve drug delivery and acceptability in the treatment of Rhizopus sp-induced IFI.

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How to Cite
Oluwasegun, A., Kosisochukwu, I., Ume, O., Igharo, A., Kehinde, I., Adedeji, I., Adeboye, O., & Didacus, N. (2024). Production and Characterisation of Microencapsulated Particles of Harugana madagascariensis: a Natural Fungicide with an Improved Delivery Potential. Tropical Journal of Natural Product Research (TJNPR), 8(10), 8889-8895. https://doi.org/10.26538/tjnpr/v8i10.34
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Articles
Author Biography

Aiseosa Igharo, Igbinedion College of Health Technology, Edo State, Nigeria

Department of Pharmaceutical Technology, College of Pharmacy, Igbinedion University, Nigeria

How to Cite

Oluwasegun, A., Kosisochukwu, I., Ume, O., Igharo, A., Kehinde, I., Adedeji, I., Adeboye, O., & Didacus, N. (2024). Production and Characterisation of Microencapsulated Particles of Harugana madagascariensis: a Natural Fungicide with an Improved Delivery Potential. Tropical Journal of Natural Product Research (TJNPR), 8(10), 8889-8895. https://doi.org/10.26538/tjnpr/v8i10.34

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