Exploring the Potential of Tamarillo (Cyphomandra betacea Cav) Compounds for the Treatment of Type 2 Diabetes Mellitus: A Network Pharmacology Study
Main Article Content
Abstract
a
Downloads
Article Details
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
How to Cite
References
Refiani E, Maliza R, Fitri H, Lestari P. Therapeutic Effects of Medicinal Plants on Diabetic Foot Ulcers : A Systematic Review. J Agromedicine Med Sci. 2021; 7(3):167-176.
Harbuwono DS, Wibowo H, Bonita RY. Analysis of MCP-1 Levels and TNF-alfa/Il-10 Ratio in First Degree Relatives (FDR) Type 2 Diabetes Mellitus Subjects with High Fat Diet Treatment. J Ilm Kesehat. 2023; 5(2):312-322.
Joshua PE, Iloka OC, Okeke ES, Aham EC, Oka SA, Onyemuche TN, Nwodo OF. Antidiabetic and Hepatoprotective Effects of Psidium guajava L Fruit Puree on Alloxan-induced Diabetes in Wistar Rats. Trop J Nat Prod Res. 2022; 6(5):795-800.
Tandra H. Penderita Diabetes Boleh Makan Apa. In: Gramdesia Pustaka Utama. ; 2021.
Widiyoga CR, Saichudin, Andiana O. Relationship between the Level of Knowledge about Diabetes Mellitus in Sufferers and the Regulation of Eating Patterns and Physical Activity. Sport Sci Heal. 2020; 2(2):152-161.
Vifta RL, Luhurningtyas FP, Wening DK. Product Introduction of Wet Noodles Combination of Yellow Pumpkin Flour and Mocaf Flour as a Low Glycemic Index Food to Prevent Obesity for Toddlers. Indones J Community Empower. 2022; 4(1):62.
Sari Y, Santoni A, Elisabet E. Comparative Test of Color Stability between Betalain Pigments of Red Dragon Fruits and Anthocyanin Pigments from Tamarillo Fruit at Various pH. J Kim Sains dan Apl. 2018; 21(3):107-112.
Febricia GP, Nocianitri KA, Pratiwi IDPK. The Effect of Fermentation Time on Characteristics of Tamarillo Juice (Solanum betaceum Cav.) Probiotic Drink with Lactobacillus sp. F213. J Ilmu dan Teknol Pangan. 2020; 9(2):170-180.
Suzanna A, Wijaya M, Fadilah R. Changes in the Chemical Content of Tamarillo Fruit (Cyphomandra betacea) After Being Processed Into a Soft Drink. J Pendidik Teknol Pertan. 2019; 5(1):S21-S36.
Devi NPA, Wipradnyadewi PAS, Yusa NM. Effect of Adding Tamarillo (Solanum betaceum Cav.) on Marshmallowed Characteristics. J Ilmu dan Teknol Pangan. 2018; 7(1):23.
Berawi KN, Asvita SM. Effectiveness of Tamarillo Extract for Decreasing Blood Glucose and LDL Cholesterol Levels in Obese Patients. Majority. 2016; 5(1):102-106.
Tjandrawinata RR, Amalia AW, Tuna H, Saidi VN, Tan S. Molecular Mechanisms of Network Pharmacology-Based Immunomodulation of Huangqi (Astragali Radix). J Ilmu Kefarmasian Indones. 2022; 20(2):184-195.
Syahrir NHA, Afendi FM, Susetyo B. Synergistic Effect of Tissue-Based Medicinal Plant Active Ingredients with Target Proteins. J Jamu Indones. 2016; 1(1):35-46.
Permatasari GW, Atho’illah MF, Putra WE. Target protein prediction of Indonesian jamu turmeric acid (Curcumin-tamarind) for dysmenorrhea pain reliever: A network analysis approach. J Kedokt dan Kesehat Indones. 2021; 12(3):238-242. doi:10.20885/jkki.vol12.iss3.art7
Rosyadah M, Afendi FM, Kusuma WA. Decoding the Working Mechanism of Herbal Medicine Using Tripartite Graph Analysis on Compound-Protein-Disease Networks. J Jamu Indones. 2017; 2(1):8-16.
Qomariasih N, Susetyo B, Mochamad Afendi F. Simultaneous Cluster Analysis and Pharmacological Networks between Compounds and Target Proteins in Determining Active Compounds in Type 2 Anti-Diabetes Herbal Medicine. J Jamu Indones. 2016; 1(2):30-40.
Hartini YS, Maharani BA, Widyantara KA, Saputra BW, Setyaningsih D, Setiawati A. Molecular Cascade of Neolignan as A Natural Anti-Diabetics Agent: A Bioinformatics Approach. Trop J Natl Prod Res. 2023; 7(11):5188-5194.
Yusuf M, Pirman, Nur Fitriani UA, Amri I, Juwita AI. Identifications of Polyphenols and α-Amylase Inhibitory Activity of Multi herbal Formulation: Cocoa Beans (Theobroma cocoa), Buni (Antidesma bunius L. Spreng), and Cinnamons (Cinnamomum cassia). J Phys Conf
Ser. 2021; 1783(1):0-8.
Valentini A, Cardillo C, Della Morte D, Tesauro M. The Role of Perivascular Adipose Tissue in the Pathogenesis of Endothelial Dysfunction in Cardiovascular Diseases and Type 2 Diabetes Mellitus. Biomedicines. 2023; 11(11):3006.
Howlader M, Sultana MI, Akter F, Hossain MM. Adiponectin Gene Polymorphisms Associated with Diabetes Mellitus: A Descriptive Review. Heliyon. 2021; 7(8) :1-9.
Nguyen TMD. Adiponectin: Role in Physiology and Pathophysiology. Int J Prev Med. 2017; 11:136.
Maximus PS, Al Achkar Z, Hamid PF, Hasnain SS, Peralta CA. Adipocytokines: Were they the Theory of Everything? Cytokine. 2020;
(1):1-10.
Berezin AE, Berezin AA, Lichtenauer M. Emerging Role of Adipocyte Dysfunction in Inducing Heart Failure among Obese Patients with Prediabetes and Known Diabetes Mellitus. Front Cardiovasc Med. 2020; 7(58):1-20.
Ramatillah DL, Enrick KE, Agatha AS, Risa GY, Sandy FG. Improvement Quality of Life in Patients with Diabetes Mellitus Type 2. J Pengabdi Kpd Masy. 2022; 1(2):14-23.
Semi H, Yuliana S, Saldy Y. The Effect of Insulin Injection Technique Education on Glycemic Control in Diabetes Mellitus Patients: A Systematic Review. Semin Nas Ris Kedokt. 2021; 2(1):106-116.
Ariqoh DN, Novitasari D, Adriani P, Kurniasih NA. Hyperglycemia Management to Overcome the Risk of Instability in Blood Glucose Levels in T2DM Sufferers. J Altifani Penelit dan Pengabdi Kpd Masy. 2022; 2(4):378-386.
Tran N, Pham B, Le L. Bioactive Compounds in Anti-Diabetic Plants: From Traditional Medicine to Modern Drug Discovery. Biology (Basel). 2020; 9(252):1-31.
Alzamil H. Elevated Serum TNF- α is Related to Obesity in Type 2 Diabetes Mellitus and is Associated with Glycemic Control and Insulin Resistance. J Obes. 2020; 2020:5-9. doi:10.1155/2020/5076858
Tedjamartono TD, Mahardhika GS, Zain H. Hyperglycemia Induced by COVID-19 with and without Present Diabetes: A Systematic Review. J Kesehat dan Kedokt. 2021; 2(2):64-74.
Diep T, Pook C, Yoo M. Phenolic and Anthocyanin Compounds and Antioxidant Activity of Tamarillo (Solanum betaceum Cav.). Antioxidants. 2020; 9(2):1-20.
Elizalde-Romero CA, Montoya-Inzunza LA, Contreras-Angulo LA, Heredia JB, Gutiérrez-Grijalva EP. Solanum Fruits: Phytochemicals, Bioaccessibility and Bioavailability, and Their Relationship with Their Health-Promoting Effects. Front Nutr. 2021; 8:1-9.
Puspawati GAKD, Marsono Y, Armunanto R, Supriyadi. Inhibitory potency of Indonesian tamarillo (Solanum betaceum Cav.) Crude Extract Against α-glucosidase Enzyme Activity. Curr Res Nutr Food Sci. 2018; 6(2):392-403.
Reyes-García V, Totosaus A, Pérez-Chabela L, Juárez ZN, Cardoso-Ugarte GA, Pérez-Armendáriz B. Exploration of the Potential Bioactive Molecules of Tamarillo (Cyphomandra betacea): Antioxidant Properties and Prebiotic Index. Appl. Sci. 2021 ; 11(23),11322; https://doi.org/10.3390/app112311322
Fredrika L, Yanti L. The Effect of Tamarillo (Solanum betaceum Cav.) Juice on Hemoglobin Levels in Nursing Students at the Faculty of Health Sciences, Muhammadiyah University of Bengkulu. J Keperawatan Muhammadiyah Bengkulu. 2021; 9(2):19-26.
Suárez-Montenegro ZJ, Ballesteros-Vivas D, Gallego R, Valdés A, Sánchez-Martínez JD, Parada-Alfonso F, Ibáñez E, Cifuentes A. Neuroprotective Potential of Tamarillo (Cyphomandra betacea) Epicarp Extracts Obtained by Sustainable Extraction Process. Front Nutr. 2021; 8:1-18.
Diep TT, Yoo MJY, Pook C, Sadooghy-Saraby S, Gite A, Rush E. Volatile Components and Preliminary Antibacterial Activity of Tamarillo (Solanum betaceum cav.). Foods. 2021; 10(9):1-19.
Diep TT, Yoo MJY, Rush E. Effect of Tamarillo Fortification and Fermentation Process on Physicochemical Properties and Nutrient and Volatiles Content of Yoghurt. Foods. 2022; 11(1):79.