Molecular Docking Study of Quercetin from Ethanol Extract of Mimosa pudica Linn on Asthma Biomarkers
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Abstract
Asthma is a chronic disease affecting approximately 12% of pregnant women, with prevalence rates reported to be as high as 16%. Managing asthma in pregnancy can have implications for the foetus, thus making the choice of treatment crucial. Antihistamines play a key role in managing asthma by addressing allergies and reducing bronchial contractions. Mimosa pudica L, a medicinal plant, may offer potential benefits in managing asthma during pregnancy due to its quercetin content. This study aims to determine the quercetin content of the ethanol extract of Mimosa pudica (EEMP), and investigate its antiasthmatic activity in silico. EEMP was obtained by maceration in ethanol at room temperature for 24 h. The quercetin content was determined by thin-layer chromatography (TLC)-densitometry. The antiasthmatic activity was investigated via molecular docking of the test ligand (quercetin) with asthma biomarkers - histamine and immunoglobulin E (IgE) using various docking tools, including Lenovo Ideapad, AutoDock Tools (v1.5.6), Biovia Discovery Studio, AutodockVina, Swiss ADME, VegaZZ, PubChem, and the pkCSM web server. Quercetin content in EEMP was found to be 327.61 mg/kg. Quercetin demonstrated a high docking score, which was comparable to that of the control ligand prednisolone. Molecular docking interactions of quercetin with IgE showed a docking score of -4.20 kcal/mol, which was more favourable than that of prednisolone. However, for histamine, the average docking score was -7.85 kcal/mol, which was less favourable than that of prednisolone. These findings suggest that quercetin could serve as a potential treatment for reducing IgE and histamine levels in individuals with asthma.
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Tegethoff, Marion , Naomi, Greene, Olsen, Jørn , Schaffner, Emmanuel and Meinlschmidt G. Inhaled Glucocorticoids during Pregnancy and Offspring Pediatric Diseases. 2012;(6):7–13.
Meakin AS, Saif Z, Jones AR, Aviles PFV, Clifton VL. Review: Placental adaptations to the presence of maternal asthma during pregnancy. Placenta [Internet]. 2017;54:17–23. Available from: http://dx.doi.org/10.1016/j.placenta.2017.01.123
Baghlaf H, Spence AR, Czuzoj-Shulman N, Abenhaim HA. Pregnancy outcomes among women with asthma. J Matern Neonatal Med [Internet]. 2019;32(8):1325–1331. Available from: https://doi.org/10.1080/14767058.2017.1404982
Aliyu IM, Magaji MG, Yau J, Muhammed DN, Ibrahim ZYY. Airway Smooth Muscles Relaxant and Mast Cells Stabilizing Activity of Some Medicinal Plants Used in Managing Asthma in North-Western Nigeria. Trop J Nat Prod Res. 2022;6(8):1241–1248.
Siddiqui F, Malik AA. Comparison of oxidative stress markers and anti-oxidant defense system in asthamatic and non-asthamatic women during second trimester of pregnancy. Khyber Med Univ J. 2020;12(2):81–85.
Wulan W, Yudistira A, Rotinsulu H. Antioxidant Activity Test of Mimosa pudica Linn. Leaf Ethanol Extract Using the DPPH Method.". Pharmacon. 2019;8(1):106.
Grieger JA, Wood LG, Clifton VL. Improving asthma during pregnancy with dietary antioxidants: The current evidence. Nutrients. 2013;5(8):3212–3234.
McLay JS, Izzati N, Pallivalapila R, Shetty. Pregnancy, prescription medicines and the potential risk of herb-drug interactions: A cross-sectional survey. BMC Complement anAbduld Altern Med. 2017;17(1):1–8.
Kemppainen M, Lahesmaa-Korpinen AM, Kauppi P, Virtanen M, Virtanen SM, Karikoski R, et al. Maternal asthma is associated with increased risk of perinatal mortality. PLoS One. 2018;13(5):1–10.
Gatford KL, Wooldridge AL, Kind KL, Bischof R, Clifton VL. Pre-birth origins of allergy and asthma. J Reprod Immunol [Internet]. 2017;123(July):88–93. Available from: http://dx.doi.org/10.1016/j.jri.2017.07.002
Rahayu I, Timotius KH. Phytochemical Analysis, Antimutagenic and Antiviral Activity of Moringa oleifera L. Leaf Infusion: In Vitro and In Silico Studies. Molecules. 2022;27(13).
Nials AT, Uddin S. Developmental perturbation induced by maternal asthma during pregnancy: The short- and long-term impacts on offspring. Clin Exp Allergy [Internet]. 2018;178(2):497–507. Available from: http://dx.doi.org/10.1016/j.placenta.2017.01.123
Ramesh S, Karthikeyan K, Chandran C. Photochemical screening and pharmacognostic studies.pdf. 2017;4(4):170–175.
Ijaz S, Shoaib Khan HM, Anwar Z, Talbot B, Walsh JJ. HPLC profiling of Mimosa pudica polyphenols and their non-invasive biophysical investigations for anti-dermatoheliotic and skin reinstating potential. Biomed Pharmacother [Internet]. 2019;109(October 2018):865–875. Available from: https://doi.org/10.1016/j.biopha.2018.10.089
Patro G, Bhattamisra S, Mohanty B, Sahoo H. In vitro and in vivo Antioxidant evaluation and estimation of total phenolic, flavonoidal content of Mimosa pudica L. Pharmacognosy Res. 2016;8(1):22–28.
Nur S, Hanafi M, Setiawan H, Nursamsiar N, Elya B. Molecular Docking Simulation of Reported Phytochemical Compounds from Curculigo latifolia Extract on Target Proteins Related to Skin Antiaging. Trop J Nat Prod Res. 2023;7(11):5067–5080.
Yamauchi K, Ogasawara M. The role of histamine in the pathophysiology of asthma and the clinical efficacy of antihistamines in asthma therapy. Int J Mol Sci. 2019;20(7).
Goldstein JA, Gallagher K, Beck C, Kumar R, Gernand AD. Maternal-Fetal Inflammation in the Placenta and the Developmental Origins of Health and Disease. Front Immunol. 2020;11(November):1–14.
Holt PG, Strickland DH, Custovic A. Targeting maternal immune function during pregnancy for asthma prevention in offspring: Harnessing the “farm effect”? J Allergy Clin Immunol [Internet]. 2020;146(2):270–280. Available from: https://doi.org/10.1016/j.jaci.2020.04.008
García Reyes Murthi P, Pinar , Dimitriadis , ... Inflammasomes—A Molecular Link for Altered Immunoregulation and Inflammation Mediated Vascular Dysfunction in Preeclampsia. Int J of …. 2020;53(9):1689–1699.