Analgesic, Anti-Inflammatory and Anti-Gastric Ulcer Potential of Aqueous Leaf Extract of Emilia sonchifolia in Rats
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Abstract
Emilia sonchifolia is used in traditional medicine for the treatment of wounds, diabetes, inflammation and ulcer. This study aims to investigate the analgesic, anti-inflammatory and anti-ulcer effects of the aqueous leaf extract of Emilia sonchifolia (ALEES). In the acute toxicity test, ALEES was administered up to 5 g/kg body weight via oral route. In the ulcer experiments, Group IIVI rats were pretreated with 1000 mg/kg ethanol or ibuprofen before Group III rats received 20 mg/kg omeprazole and Group IVVI rats received various doses of ALEES. In the anti-inflammatory and analgesic studies, group II rats received 100 mg/kg acetylsalicylic acid (ASA). For the ulcer, anti-inflammatory and analgesic studies, rats were administered ALEES at doses of 200, 400 and 600 mg/kg body weight while group I served as a normal control. In ethanol-induced ulcer, rats administered 600 mg/kg ALEES showed a higher percentage (%) ulcer inhibition compared to standard drug (omeprazole) treated group (p<0.05). The % ulcer inhibition in the ibuprofen-induced ulcer test did not exhibit any significant changes (p>0.05) between the group treated with 600 mg/kg ALEES and the omeprazole group. In addition, there was no significant anti-inflammatory activity between ALEES at a dose of 600 mg/kg (52.78%) and ASA at a dose of 100 mg/kg (66.61%), however, ASA had a stronger analgesic effect compared to all ALEES-treated groups (p<0.05). The results of this study suggest that ALEES is safe and has the potential to be used as an anti-ulcer and anti-inflammatory agent.
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