The Antibacterial and Anti-Breast Cancer Activities of Caulerpa racemosa from the Minahasa Peninsula Water and North Sulawesi, Indonesia
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Abstract
Caulerpa racemosa is a type of green algae recognised for its ability to inhibit the growth of bacteria and its potential to combat breast cancer. The algae are composed of several bioactive chemicals, such as flavonoids, phenols, tannins, saponins, steroids, alkaloids, and terpenoids. Hence, this study aimed to ascertain the antibacterial and anti-breast cancer properties of Caulerpa racemosa extract obtained from the Minahasa Peninsula, notably the North and Southeast water regions. The anticancer test assessed the algae extract cytotoxicity against MCF7 breast cancer cells using the MTT assay for direct measurements. The antibacterial test employed the Kirby Bauer disc diffusion method. The findings indicated that the extract of Caulerpa racemosa collected from the water in North Minahasa exhibited a potent antibacterial activity. The substantial antibacterial action of the substance was demonstrated by an average inhibition zone of 13.5 mm against Mycobacterium smegmatis at a concentration of 1 mg/mL, the highest concentration tested. The extract from water in the North and Southeast Minahasa regions exhibited significant anticancer activity, with IC50 values of 149.9 ppm and 313.2 ppm, respectively.
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Handayani T. Macroalgae Diversity in Kendari Bay and Surrounding Waters, Southeast Sulawesi. Oceanol Limnol Indones. 2021; 6(1):55–69.
Yanuhar U. Marine Microalgae Nannochloropsis oculata. Malang: UB Press; 2016.
Dwi SS, Eriyanto Y. Increase in Secondary Metabolite Content in Various Bean Plants as a Response to Biotic Stress. Food Plant Res Dev Center. 2016; 11(2):167–74.
Yoga WK, Komalasari H. Potential of Green Algae (Caulerpa Racemosa) as a Source of Natural Antioxidants: Rev. J Technol Food Qual. 2022; 1(1):15–8.
Candrawati A. Analysis of Factors That Influence Turnaround Success in Companies ExperiencingFinancial Distress (Study of Non-Financial Companies Listed on the Jakarta Stock Exchange 2000- 2005). Master of Management Study Program, Diponegoro University Postgraduate Program.Universitas Diponegoro; 2008.
Kurniawan MR, Sapar A, Aritonang AB. Toxicity and phytochemical tests of the sponge Haliclona sp. origin of Lemukutan island, Bengkayang district, west Kalimantan. J Kim Equator. 2021; 9(1):1–5.
Maarisit W, Abdjul DB, Yamazaki H, Kato H, Rotinsulu H, Wewengkang DS, Sumilat DA, Kapojos MM, Ukai K, Namikoshi M. Anti-mycobacterial alkaloids, cyclic 3-alkyl pyridinium dimers, from the Indonesian marine sponge Haliclona sp. Bioorg Med Chem Lett. 2017; 27(15):3503-3506.
WHO. Global Tuberculosis Report. Vol. 4, World Health Organization. World Health Organization; 2022.
Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CACancer J Clin. 2018;68(6):394–424.
Istini. Pemanfaatan Plastik Polipropilen Standing Pouch Sebagai Salah Satu Kemasan Sterilisasi Peralatan Laboratorium. Indones J Lab. 2020;2(3):41–6.
Mpila D., Fatimawali, Wiyono WI. In-vitro test of the antibacterial activity of Mayana leaves (Coleus atropurpureus [L] Benth) Terhadap Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa. Pharmacon. 2012;1(1):13–21.
MaarisitW,UntuSD,LengkeyYK,MongiJ,KanterJW, Pareta DN, et al. Isolation and Evaluation of Anti-Mycobacterial Activity of Alkaloid Compounds from Marine Invertebrate Sponge Haliclona sp. Trop J Nat Prod Res. 2022;6(10):1622–5.
Winarno EK, Mazda, Rahmawati H, Winarno H. Effect Of Gamma Irradiation On The CytotoxicActivity Of The Flesh Of The Crown Of The Gods (Phaleria macrocarpa (Scheff) Boerl.). Indon J. Nuclear Sci and Techn. 2010;11(2):67–76.
Winarno E. Cytotoxic Test of Aspergillus sp Mold Extract Against T47D Breast Cancer Cells. Faculty of Mathematics and Natural Sciences, Biology Undergraduate Study Program, Universityof Indonesia. University of Indonesia; 2011.
Haryoto, Muhtadi, Indrayudha P, Azizah T, Suhendi A. Cytotoxic Activity of Ethanol Extract of Sala (Cynometra ramiflora Linn) Plants Against HeLa, T47D and WiDR Cells. J Sci Res. 2013;18(2):21–28.
Weerapreeyakul N, Nonpunya A, Barusrux S, Thitimetharoch T, Sripanidkulchai B. Evaluation ofthe anticancer potential of six herbs against a hepatoma cell line. Chin Med. 2012; 7(15):1–7.
Rohman A, Sudjadi, Devi, Ramadhani D, Nugroho A. Analysis of curcumin in Curcuma longa and Curcuma xanthorriza using FTIR spectroscopy and chemometrics. Res J Med Plant [Internet]. 2015; 9(4):179–86. Doi: 10.3923/rjmp.2015.179.186
Hanani E. Phytochemical Analysis. EGC Medical Book Publishers; 2016.
Aulia SS, Sopyan I, Muchtaridi. Determination of Simvastatin Concentrations Using High-Performance Liquid Chromatography (HPLC): Review. Pharmaca. 2016;14(4):70–78.
Tethool AM, Tulandi SS, Tulandi H V., Paat VI, Potalangi NO. Tropical Biopharmaceuticals. The Trop J Biopharm. 2021; 4(2):33–8.