Assessment of the Antioxidant Capacity and Cytotoxic Activity of pomoea pes-tigridis
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Abstract
Cancer, one of the deadliest diseases, is the second leading cause of mortality all over the world. The study aims to investigate the phytochemical profile and in vitro antioxidant activity of ethanol extracts from Ipomoea pes-tigridis and assess its cytotoxicity against three cell lines. Its qualitative and quantitative phytochemical analysis revealed that the plant possesses various secondary
metabolites like tannins and flavonoids, which have potent antioxidant properties. The DPPH (2,2-Diphenyl-1-picrylhydrazyl) and nitric oxide (NO) free radical assays showed promising in vitro antioxidant potential. The ethanol extracts demonstrated significant cytotoxicity against A375, B16-F10, and NHDF cell lines, with IC50 values ranging from 12.02 ± 3.14 μg/mL to 136.42 ± 2.92 μg/mL. These findings suggest that Ipomoea pes-tigridis may contain compounds with potential anticancer properties, which warrant further investigation for identification and characterisation. The observed activities of the plant can be credited to the polyphenolic compounds, and future research is needed to assess the detailed phytochemistry and biological activities of Ipomoea pestigridis.
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