Animal model assessment of HELLP Syndrome during Treatment with Methanol Plant Extracts of Jatropha curcas, Alchonnea cordifolia, and Secamone afzelii

Abstract

In treating preeclampsia-induced wistar rats, this study examined the effects of methanolic plant extracts of Jatropha curcas, Alchonnea cordifolia, and Secamone afzelii, respectively, on the evaluation of HELLP syndrome. Fifteen sets of age-matched female Wistar rats were employed, with one serving as a control group. The Adriamycin Model was used to induce preeclampsia. The rats were then administered 50, 100, and 200 mg/kg of the extracts. Another group was administered methyl DOPA (at 10 mg/kg). At the end of the study, the arts were anesthetized and sacrificed humanely. Platelet counts, hemoglobin, and liver enzymes were measured following standard procedure. The study found that extracts of plant extracts did not cause any toxic effects on test animals, and there was no mortality at 5000 mg/kg. Aspartate transaminase levels increased during preeclampsia, but J. curcas and A. cordifolia extracts at low-to-moderate concentrations reduced these levels. Post-partum AST levels decreased from 60.7 U/l during preeclampsia to 25.3 - 39.2 U/l. There were no significant alterations in total protein levels (p>0.05). Preeclamptic Wistar rats treated with theextracts showed higher packed cell volume and platelet counts during preeclampsia. Upon administration of 100 mg/kg J. curcas and 200 mg/kg S. afzelii, the prognosis of preeclampsia was generally better after postpartum than during the third trimester.The study reveals that preeclampsia treatment with J. curcas, A. cordifolia, and S. afzelii extracts improves liver enzymes, total protein levels, packed cell volume, and platelet counts, suggesting potential therapeutic options.