Impact of Corchorus olitorius Leaf Extract on Potassium Bromate-Induced Haematological Parameters Derangement in Rats
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Abstract
Blood is one of the human tissues in which potassium bromate (KBrO3) is hazardous. This investigation aims to assess the impact of Corchorus olitorius (C. olitorius) on KBrO3-induced haematological parameters derangement. C. olitorius leaves were extracted with a soxhlet extractor and a solvent of 95% ethanol. Groups A, B, C, and D were created from twenty-four mature male Wistar rats acclimated for seven days. Group A was given distilled water orally. In addition to the 100 mg/kg b.w of KBrO3 given to groups B, C, and D of animals, 100 and 200 mg/kg body weight of C. olitorius were also administered to groups C and D respectively. After the 28-day treatment period, blood samples were collected for examination. Animals intoxicated with KBrO3 demonstrated substantial (P<0.05) decrease in most blood parameters compared to the animals in the control group (haemoglobin level, red blood cell count, packed cell volume, total white cell count, neutrophil count, lymphocyte count, monocyte count and platelet count). The disordered haematological parameters were, however, dose-dependently corrected in the potassium bromate-intoxicated rats treated with C. olitorius. KBrO3 caused a significant decrease in haemoglobin level, red blood cell count, packed cell volume, total white blood cell count, neutrophil count, lymphocyte count, monocyte count and platelet count as well as elevated erythrocyte sedimentation rate (ESR), but C. olitorius treatment reversed these effects. Therefore, more studies are needed to further validate these findings.
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References
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