Glucogallin and Conjugated Linoleic Acids Isolated from Ricinodendron heudelotii (Bail.) Seeds
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Abstract
In a bid to explore and enhance the use of natural products for medicinal purposes, this study analyzed the crude extract of Ricinodendron heudelotii seeds and isolated four biologically active compounds from ethyl acetate fraction of R. heudelotii seeds extract. The study utilized GC-MS in the analysis of the crude extract. Various spectroscopic and spectrometric methods in addition to reported data were employed in characterizing isolates. Twenty-two compounds were detected in the crude extract via GC-MS. Palmitic acid had the highest abundance of 23.9%, followed by α-linolenic acid (14.72%). The ethyl acetate fraction by means of chromatographic techniques yielded four compounds namely glucogallin (1), (6Z,9Z,11Z)-6,9,11-octadecatrienoic acid (2), (6Z,9E,11E)-6,9,11-octadecatrienoic acid (3) and (6Z,9Z,13Z)-6,9,13-octadecatrienoic acid (4). All four isolated compounds have biological and pharmaceutical properties including anti-inflammatory and anti-diabetic. This study, therefore, proposes linolenic acid and gallic acid derivatives as chemophenetic markers of R. heudelotii and suggests the medicinal use of R. heudelotii seeds for anti-inflammatory and anti-diabetic disorders.
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