Histopathological Profile of Rats (Rattus norvegicus) with Collagen-Type II Rheumatoid Arthritis and treated with Purslane Tea (Portulaca oleracea Linn.)
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Abstract
Rheumatoid arthritis (RA) is an autoimmune disease characterized by chronic inflammation and can be treated with drugs such as methotrexate. However, the use of this drug can cause severe adverse effects. The development of herbal medicines has become an alternative therapy for treating rheumatoid arthritis. Purslane (Portulaca oleracea L.) is one of the plants that can treat RA, which contains saponins, flavonoids, omega-3 fatty acids, and phenolic acids. Purslane has been widely developed into herbal tea. This study aimed to determine the effect of purslane tea on the histopathological change of the rat’s joint (Rattus novergicus) with rheumatoid arthritis. This test uses the collagen-induced arthritis (CIA) method. This method was carried out by inducing bovine type II collagen emulsified with Complete Freund’s Adjuvant (CFA) as an immunization phase and with Incomplete Freund’s Adjuvant (IFA) as a booster phase in the tail of the rats. This study consisted of 3 groups: sodium CMC (control group), methylprednisolone (control positive), and the purslane tea group. Parameters were observed in the histopathological analysis of the rats’ joints. The results of the histopathological analysis showed that purslane tea influences the prevention of synovial joint damage by inhibiting joint erosion and pannus formation in the synovial joints of rheumatoid arthritis rats. The study concludes that purslane tea is an effective and alternative medicine for treating rheumatoid arthritis.
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World Health Organization. (n.d.). Rheumatoid Arthritis. World Health Organization. Retrieved June 28, 2023, from https://www.who.int/news-room/fact- sheets/detail/rheumatoid-arthritis
Koda-Kimble MA, & Alldredge BK. Koda-Kimble and Young’s Applied Therapeutics: The clinical use of drugs. Tenth Edition. Lippincott Williams & Wilkins. 2013.
Dipiro JT, Yee GC, Posey LM, Haines ST, Nolin TD, & Ellingrod VL.
Pharmacotherapy: A pathophysiologic approach. McGraw Hill Medical. 2020.
Kemenkes RI. Laporan Provinsi Sulawesi Selatan RISKESDAS 2018. Lembaga Penerbit Badan Penelitian Dan Pengembangan Kesehatan. Jakarta. 2019.
Arthritis Foundation from https://www.arthritis.org.
Srikartika VM, Anwar K & Amalia. Evaluation of Side Effects in Rheumatoid Arthritis Patients Using DMARDs at Hospitals in Banjarmasin. J. Pharm. Sci. 2021; 8(2):103.
Asmaliani I and Iwo MI. The effect from methanol extract of jackfruit leaves (Artocarpus heterophyllus Lam) in rheumatoid arthritis rat induced collagen type II. Der P. Lettre. 2016; 8 (18):180-184.
Azizah RN, Emelda A, Asmaliani I, Ahmad I, Fawwaz M. 2022. Total Phenolic, Flavonoids, and Carotenoids Content and Anti-Obesity Activity of Purslane Herb (Portulaca oleracea L.) Ethanol Extract. Pharmacogn J. 2022; 14(1):1-6
Thao TTP, Tu PTC, Men TT. A Comparative Study on Polyphenol, Flavonoid Content, Antioxidant and Anti-Inflammatory Capacity of Different Solvent Extract from Portulaca oleracea in Carrageenan-Induced Paw Edema in Mice. Trop J Nat Prod Res. 2023; 7(10):4152-4159
Van Anh NT, Luyen LH. Potential Inhibitory Effects on Human Platelet Aggregation and Blood Coagulation of the Aerial Part of Portulaca oleracea L: Trop J Nat Prod Res. 2024;8(1):6001-5.
Sohemat AA, Atrooz OM, Farah HS. Erratum: Evaluation of the Anti-inflammatory, Antioxidant, and Protease Inhibitory Activity of the Crude Methanol Extract of Portulaca oleracea Trop J Nat Prod Res. 2023;7(3):2397-401.
Andayani D, Suprihartini E, & Astuti M. Anti-Inflammatory Effect of Ethanol Extract of Purslane (Portulaca oleracea L.) on Carrageenin-Induced Mouse Edema. JPSCR. 2018; 3(1): 44
Putra RP, Aisyah SI, Nurcholis W. Benefits of Total Phenolic and Flavonoid Content of Portulaca oleracea as Antioxidant and Antidiabetic: A Review. Trop J Nat Prod Res. 2023; 7(2):2293-2304
Azizah, R.N., Asmaliani, I., Putra, B., & Riskiwati. Antirheumatoid Arthritis Effect of Purslane Herb Extract (Portulaca oleracea L.) to Rat (Rattus novergicus) Induced by Complete Freud's Adjuvant’. JGPT. 2019; 11(4):314.
Azizah, Rizqi Nur. Krokot (Portulaca oleracea L.) Contemporary Herbal Drinks: MSME Business Opportunities. Solok: Muslim Scholars Education Foundation. 2023.
Bendele, A.M. 2001. Animal Models of Rheumatoid Arthritis. JMNI. 2001; 1(4):379-380
An YH & Martin KL. Handbook of Histology Methods for Bone and Cartilage. Springer Science Business Media. New York. 2003
Dey P. Basic and Advanced Laboratory Techniques in Histopathology and Cytology. Springer Nature Singapore. Singapore. 2018
Uddin MK, Juraimi AS, Hossain MS, Nahar MAU, Ali ME, Rahman MM. Purslane weed (Portulaca oleracea): a prospective plant source of nutrition, omega-3 fatty acid, and antioxidant attributed. Sci. World J. 2014; 951019-951019.
Rahimi VB, Ajam F, Rakhshandeh H, Askari VR. A Pharmacological Review on Portulaca oleracea L.: Focusing on Anti-Inflammatory, Anti-Oxidant, Immuno-Modulatory and Antitumor Activities. J Pharmacopuncture. 2019; 22(1):7-15.
Zhou YX, Xin HL, Rahman K, Wang SJ, Peng C, Zhang H. Portulaca oleracea L.: a review of phytochemistry and pharmacological effects. Biomed Res Int. 2015; 2015: 925631.
Dipiro JT, Yee GC, Posey LM, Haines ST, Nolin TD, & Ellingrod V. Pharmacotherapy A Pathophysiologic Approach 11th Edition. McGraw Hill. America. 2020
Allen DC, & Cameron RI. Histopathology Specimens: Clinical, Pathological and Laboratory Aspects 3rd Edition. Springer International Publishing AG. Switzerland. 2017.
Azizah RN, Emelda A, & Asmaliani I. Potential of the Purslane Plant as an Anti-Obesity Drug Ingredient. Muslim Scholars Education Foundation. SoloK. 2023
Putra B, Azizah RN, Nopriyanti EM. Immunomodulatory Effect of Ethanol Extract of Purslane Herb (Portulaca oleracea L.) on Male White Rats (Rattus norvegicus) with Parameter Delayed Type Hypersensitivity (DTH). Galenika J.O.P. 2020; 6(1):20-25.
Azizah RN, Putra B, Tobis R. Hypolipidemic Activity Test of Ethanol Extract of Purslane Herb (Portulaca oleracea L.) in Obese Rats Using Triglyceride Parameters. As-Syifaa J. 2018; 10(1):66-73.