Modulatory Effect of Dietary Pentadiplandra brazzeana Baill Root Supplemented Feed in Oedematous and Polyarthritic Rat
Article Sidebar
Main Article Content
Abstract
Musculoskeletal disorders including osteoarthritis, rheumatoid arthritis and rheumatism are chronic inflammations linked with intense joint pain. Pentadiplandra brazzeana Baill root (Joy perfume tree) root is a dietary food used in traditional care to manage inflammatory disorders. Anti-inflammatory, antioxidant, and immunomodulatory effects of P. brazzeana root-supplemented feed (PBRF) against acute oedema and chronic polyarthritis were studied in Wistar rats. Zingiber officinale served as the standard. Plasma alanine aminotransferase (ALT), aspartate aminotransferase (AST), oxidative stress markers were investigated using standard methods. Nuclear factor kappa B (NF-κB), cyclooxygenase-2 (COX-2), and tumour necrosis factor-alpha (TNF-α) were determined using ELISA assays. Neutrophils, monocytes, basophils, eosinophils, procalcitonin, white blood cells, platelets, haemoglobin, red-blood cells, and lymphocytes, counts were assayed using autoanalyzer. The PBRF significantly (p < 0.05) suppressed rat paw thickness in carrageenan, complete Freund’s adjuvant (CFA) and formaldehyde models. The activities of AST and ALT in formaldehyde-induced oedema model were significantly reduced by PBRF. Furthermore, PBRF significantly decreased COX-2 activity, TNF-α, NF-κB, and malondialdehyde concentrations, while reduced glutathione level, catalase, superoxide dismutase, and glutathione peroxidase activities, were significantly increased in the CFA-induced polyarthritis model. The PBRF-treated groups had low lymphocytes, basophils, white blood cells, monocytes, neutrophils, eosinophils, and procalcitonin counts, compared to the negative control diet group. The PBRF exhibited considerable anti-inflammatory, antioxidant and immunomodulatory curative effects against acute oedema and chronic polyarthritis in rats. The mechanistic action could be through, COX-2, TNF-α and NF-κB signaling pathways inhibition, boosting of the antioxidant defense system and modulation of immunological parameters.
Downloads
Article Details
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
How to Cite
References
Betrains A, Rosseels W, Van Mieghem E, Vanderschueren S, Nijs J. Clinical characteristics, treatment, and outcome of pancreatitis, panniculitis, and polyarthritis syndrome: a case-based review. Clin. Rheumatol. 2021; 40:1625-33.
Buch MH, Eyre S, McGonagle D. Persistent inflammatory and non-inflammatory mechanisms in refractory rheumatoid arthritis. Nat. Rev. Rheumatol. 2021; 17(1):17-33.
Hu Z, Song C, Xu C, Jin G, Chen Y, Xu X, Ma H, Chen W, Lin Y, Zheng Y, Wang J. Clinical characteristics of 24 asymptomatic infections with COVID-19 screened among close contacts in Nanjing, China. Sci. China Life Sci. 2020; 63:706-11.
Suzuki K. Chronic inflammation as an immunological abnormality and effectiveness of exercise. Biomol. 2019; 9(6):223.
Xu J, Cao K, Liu X, Zhao L, Feng Z, Liu J. Punicalagin regulates signaling pathways in inflammation-associated chronic diseases. Antioxid. 2021; 11(1):29.
Lindler BN, Long KE, Taylor NA, Lei W. Use of herbal medications for treatment of osteoarthritis and rheumatoid arthritis. Med. 2020; 7(11):67.
Castillo AL, De Jesus PM, Apostol JG, Yolo RT, Nonato MG. Acute toxicity and anti-inflammatory activity of the aqueous and alcohol extracts of philippine endemic pandanus spp. Acta Manil. 2023; 71:01-17.
Eledo BO, Tommy E, Onuoha E, Dunga K, Okamgba O. The prevalence of rheumatoid arthritis in the elderly that attend pilgrimage centre, Elele, Nigeria. EJMED. 2020; 2(3): 1-4.
Bøyesen P, Haavardsholm EA, Østergaard M, van der Heijde D, Sesseng S, Kvien TK. MRI in early rheumatoid arthritis: synovitis and bone marrow oedema are independent predictors of subsequent radiographic progression. Ann. Rheum. Dis. 2011; 70(3):428-33.
Alpay-Kanıtez N, Çelik S, Bes C. Polyarthritis and its differential diagnosis. Eur. J. Rheumatol. 2019; 6(4):167.
Puigdellivol J, Comellas Berenger C, Pérez Fernández MÁ, Cowalinsky Millán JM, Carreras Vidal C, Gil Gil I, Martínez Pagán J, Ruiz Nieto B, Jiménez Gómez F, Comas Figuerola FX, Aguilar Hernández ME. Effectiveness of a dietary supplement containing hydrolyzed collagen, chondroitin sulfate, and glucosamine in pain reduction and functional capacity in osteoarthritis patients. J. Diet Suppl. 2019; 16(4):379-89.
Qiao R, Deng Y, Zhang S, Wolosker MB, Zhu Q, Ren H, Zhang Y. Accumulation of different shapes of microplastics initiates intestinal injury and gut microbiota dysbiosis in the gut of zebrafish. Chemosphere. 2019; 236:124334.
Shah AS, Ahmed M, ul Haq, Noor, Khan RA. Protective effect of Nicotiana plumbaginifolia linn against CCL4 induced oxidative stress in gallus gallusdomesticus. Int. J. Pharmacol. 2021; 17(3):130-7.
Zilani MN, Islam MA, Biswas P, Anisuzzman M, Hossain H, Shilpi JA, Hasan MN, Hossain MG. Metabolite profiling, anti-inflammatory, analgesic potentials of edible herb 14.Colocasia gigantea and molecular docking study against COX-II enzyme. J. Ethnopharmacol. 2021; 281:114577.
Zhou Z, Xu MJ, Gao B. Hepatocytes: a key cell type for innate immunity. Cell Mol. Immunol. 2016; 13(3):301-15.
Geisen UM, Berner DK, Tran F, Sümbül M, Vullriede L, Ciripoi M, Reid HM, Schaffarzyk A, Longardt AC, Franzenburg J, Hoff P. Immunogenicity and safety of anti-SARS-CoV-2 mRNA vaccines in patients with chronic inflammatory conditions and immunosuppressive therapy in a monocentric cohort. Ann. Rheum. Dis. 2021; 80(10):1306-11.
Kato Y, Morita T, Kumanogoh A. Efficacy and risk of mRNA vaccination in patients with autoimmune inflammatory rheumatic diseases. Inflamm. Regen. 2023; 43(1):1-6.
Shimagami H, Yamaguchi Y, Kato Y, Kumanogoh A. Marked increase of interferon-β after BNT162b2 mRNA vaccination: a case of polyarthritis with pleurisy. BMJ Case Rep. 2022; 15(3):e246533.
Maniadakis N, Toth E, Schiff M, Wang X, Nassim M, Szegvari B, Mountian I, Curtis JR. A targeted literature review examining biologic therapy compliance and persistence in chronic inflammatory diseases to identify the associated unmet needs, driving factors, and consequences. Adv. Ther. 2018; 35:1333-55.
Zhang G, Kandhare AD, Mukherjee AA, Bodhankar SL, Yin H. Ameliorative effect of morin, a plant flavonoid against Freund's complete adjuvant-induced polyarthritis in rats. Pharmacogn. Mag. 2019; 15(60): 43-61
Egbule MN, Shokunbi OS, God’swill NA. Evaluation of proximate and phytochemical constituents of Pentadiplandra brazzeana baill (“osumada”) roots. Nig. J. Biochem. Mol. Bio. 2022; 37(3):166-74.
Nwachukwu V, Udedi S, Ezeonu F, Brai B, Ezeanyanaso C, Elemo G. Bioactive agents, nutraceuticals potentials, phytochemistry, and food value of Emilia coccinea leaf: a review. J. Complement. Med. Res. 2017; 4(1):1-5.
Gunawardena D, Shanmugam K, Low M, Bennett L, Govindaraghavan S, Head R, Ooi L, Münch G. Determination of anti-inflammatory activities of standardised preparations of plant-and mushroom-based foods. Eur. J. Nutr. 2014; 53:335-43.
Taram F, Ignowski E, Duval N, Linseman DA. Neuroprotection comparison of rosmarinic acid and carnosic acid in primary cultures of cerebellar granule neurons. Molecules. 2018; 23(11):2956.
Kuwabara Y, Hirose A, Lee H, Kakinuma T, Baba A, Takara T. Effects of highly bioavailable curcumin supplementation on common cold symptoms and immune and inflammatory functions in healthy Japanese subjects: a randomized controlled study. J. Diet Suppl. 2023; 26:1-28.
Ayer C, Celep AG. Assessment of dietary habits and use of nutritional supplements in COVID-19: A cross-sectional study. PharmaNutrition. 2022; 22:100309.
Silva RF, Pogačnik L. Polyphenols from food and natural products: Neuroprotection and safety. Antioxid. 2020; 9(1):61.
Qu G, Chen J, Guo X. The beneficial and deleterious role of dietary polyphenols on chronic degenerative diseases by regulating gene expression. Biosci. Trends. 2018; 12(6):526-36.
Abenavoli L, Boccuto L, Federico A, Dallio M, Loguercio C, Di Renzo L, De Lorenzo A. diet and non-alcoholic fatty liver disease: the mediterranean way. Int. J. Environ. Res. Public Health 2019; 16(17):3011.
Cimanga KR, Lubiba NZ, Makila BM, Tona LG, Kambu KO, Vlietinck AJ, Pieters L. Biological activities of Arredoul Jaune, a phytomedicine based ethanol extract from fresh roots of Pentadiplandra brazzeana baill (Pentadiplandaceae) used as an antidiarrhoeal drug in Kisangani-Democratic Republic of Congo. Eur. J. Biomed. Pharm.Sci. 2018; 5(1):130-9.
Tsopmo A, Ngnokam D, Ngamga D, Ayafor JF, Sterner O. Urea derivatives from Pentadiplandra brazzeana. J. Nat. Prod. 1999; 62(10):1435-6.
Kitamura S, Morisseau C, Inceoglu B, Kamita SG, De Nicola GR, Nyegue M, Hammock BD. Potent natural soluble epoxide hydrolase inhibitors from Pentadiplandra brazzeana baillon: synthesis, quantification, and measurement of biological activities in vitro and in vivo. PLoS One. 2015; 10(2):e0117438.
Ndoye Foe FM, Tchinang TF, Nyegue AM, Abdou JP, Yaya AJ, Tchinda AT, Essame JL, Etoa FX. Chemical composition, in vitro antioxidant and anti-inflammatory properties of essential oils of four dietary and medicinal plants from Cameroon. BMC Complement. Altern. Med. 2016; 16(1):1-12.
Nyegue MA, Ndoye-Foe F, Etoa FX, Zollo et PH, Menut C. Study of chemical composition, growth inhibition and antigerminative effect of three essential oils from Cameroon on four bacillus strains. J. Essent. Oil Bear Pl. 2014; 17(6):1335-42.
Zheng ZH, Han Y, You SY, Chen Z, Zheng XD. Improvement in post-partum uterine involution in rats treated with Apios americana. J. Zhejiang Univ. Sci. B. 2019; 20(7):576.
Winter CA, Risley EA, Nuss GW. Carrageenin-induced edema in hind paw of the rat as an assay for antiinflammatory drugs. Proc. Soc. Exp. Biol. Med. 1962; 111(3):544-7.
Arzi A, Olapour S, Yaghooti H, Karampour NS. Effect of royal jelly on formalin induced-inflammation in rat hind paw. Jundishapur J. Nat. Pharm. Prod. 2015; 10(1).
Anyasor GN, Okanlawon AA, Ogunbiyi B. Evaluation of anti-inflammatory activity of Justicia secunda vahl leaf extract using in vitro and in vivo inflammation models. Clin. Phytosci. 2019; 5:1-13.
Reitman S, Frankel S. A colorimetric method for the determination of serum glutamic oxalacetic and glutamic pyruvic transaminases. Am. J. Clin. Pathol. 1957; 28(1):56-63.
Marklund S, Marklund G. Involvement of the superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase. Eur. J. Biochem.1974; 47(3):469-74.
Sinha AK. Colorimetric assay of catalase. Analytical biochemistry. 1972; 47(2):389-94.
Tahir M, Sultana S. Chrysin modulates ethanol metabolism in wistar rats: a promising role against organ toxicities. Alcohol Alcohol. 2011; 46(4):383-92.
Ellman GL. Tissue sulfhydryl groups. Arch. Biochem. Biophys. 1959; 82(1):70-7.
Rotruck JT, Pope AL, Ganther HE, Swanson AB, Hafeman DG, Hoekstra W. Selenium: biochemical role as a component of glutathione peroxidase. Science. 1973; 179(4073):588-90.
National Institute of Health (NIH), (2011). Guide for the care and use of laboratory animals. 8th ed. The National Academies Press. Washington D.C.
Sindhu G, Ratheesh M, Shyni GL, Nambisan B, Helen A. Anti-inflammatory and antioxidative effects of mucilage of Trigonella foenum graecum (Fenugreek) on adjuvant induced arthritic rats. Int. Immunopharmacol.2012; 12(1):205-11.
Varela ML, Mogildea M, Moreno I, Lopes A. Acute inflammation and metabolism. Inflamm. 2018; 41:1115-27.
Kitamura S, Morisseau C, Harris TR, Inceoglu B, Hammock BD. Occurrence of urea-based soluble epoxide hydrolase inhibitors from the plants in the order brassicales. PloS one. 2017; 12(5):e0176571.
Rahman MA, Hasan NAHM, Mondal M, Uddin M, Wahed TB, Alam KKM. Evaluation of antioxidant, cytotoxic and hepato-protective effect of Bridelia tomentosa fruit extract. Trop J Nat Prod Res. 2023; 7(12):5453-5459. Doi.org/10.26538/tjnpr/v7i12.14
De Nicola GR, Nyegue M, Montaut S, Iori R, Menut C, Tatibouët A, Rollin P, Ndoyé C, Zollo PH. Profile and quantification of glucosinolates in Pentadiplandra brazzeana baillon. Phytochem. 2012; 73:51-6.
Vipin AV, Rao R, Kurrey NK, KA AA, Venkateswaran G. Protective effects of phenolics rich extract of ginger against aflatoxin B1-induced oxidative stress and hepatotoxicity. Biomed Pharmacother. 2017; 91:415-24.
Eustice, C., 2021 Updated on September 24, 2021. Blood test for arthritis. [Online].2022 [cited 2021 Sept 24]. Available from https://www.verywellhealth.com/blood-tests-for-arthritis-188020
Ledingham J, Snowden N, Ide Z. Diagnosis and early management of inflammatory arthritis. BMJ. 2017; 358.
Ferenczyova K, Kalocayova B, Bartekova M. Potential implications of quercetin and its derivatives in cardioprotection. Int. J. Mol. Sci. 2020; 21(5):1585.
Ahmed KS, Ahmed SS, Thangakumar A, Krishnaveni R. Therapeutic effect of Parmotrema tinctorum against complete Freund’s adjuvant-induced arthritis in rats and identification of novel isophthalic ester derivative. Biomed Pharmacother. 2019; 112:108646.
Zahra Z, Khan MR, Shah SA, Maryam S, Majid M, Younis T, Sajid M. Vincetoxicum arnottianum ameliorate inflammation by suppressing oxidative stress and pro-inflammatory mediators in rat. J. Ethnopharmacol. 2020; 252:112565.
Chen L, Deng H, Cui H, Fang J, Zuo Z, Deng J, Li Y, Wang X, Zhao L. Inflammatory responses and inflammation-associated diseases in organs. Oncotarget. 2018; 9(6):7204.
Chen CY, Kao CL, Liu CM. The cancer prevention, anti-inflammatory and anti-oxidation of bioactive phytochemicals targeting the TLR4 signaling pathway. Int. J. Mol. Sci. 2018; 19(9):2729.
Saedisomeolia A, Arzati MM, Abdolahi M, Sedighiyan M, Rangel A, Muench G, Zarezadeh M, Jafarieh A, Honarvar NM. Mechanisms of action of ginger in nuclear factor-kappa B signaling pathways in diabetes. J. Herb. Med. 2019; 16:100239.
Pepe G, Sommella E, Cianciarulo D, Ostacolo C, Manfra M, Di Sarno V, Musella S, Russo M, Messore A, Parrino B, Bertamino A. Polyphenolic extract from tarocco (Citrus sinensis l. osbeck) clone “lempso” exerts anti-inflammatory and antioxidant effects via NF-KB and Nrf-2 activation in murine macrophages. Nutrients. 2018; 10(12):1961.
Okoro EE, Osoniyi OR, Jabeen A, Shams S, Choudhary MI, Onajobi FD. Anti-proliferative and immunomodulatory activities of fractions from methanol root extract of Abrus precatorius L. Clin. Phytosci. 2019; 5(1):1-9.
Abdou Bouba A, Njintang Yanou N, Foyet H, Scher J, Montet D, Mbofung CM. Proximate composition, mineral and vitamin content of some wild plants used as spices in Cameroon. Food Nutr. Sci. 2012; 3(4), 423-432
Anokwuru CP, God’swill NA, Shokunbi OS, Sopekan B, Osinuga OK, Afolabi OE, Arojojoye OB, Ezekiel CN, Ramaite ID. Chemoprotective activity of aqueous leaf extract of Acalypha wilkesiana against cyclophosphamide-induced toxicity in rats. Asian Pac. J. Trop. Med. 2019; 12(9):409-15.
Necdem TB, Raphaël KJ, Divine YM, Agwah ED, Ruben NT, Mikael D, Gilchrist TD, Josiane KN, Alexis T. Effects of graded levels of joy perfume tree (Pentadiplandra brazzeana) powder in drinking water on growth performance, gut microbiota and haemato-biochemical parameters of broiler chickens. Open J. Anim. Sci. 2020; 10(3):514-27.