Antiplasmodial Activity of Ethanol Extract of Sonneratia alba Leaves

Main Article Content

Muhaimin Muhaimin
Nor Latifah
Anis Y. Chaerunisaa
Anas Subarnas
Yasmiwar Susilawati
Rifanza Hirzan

Abstract

Sonneratia alba (S. alba) is a mangrove plant that represents a promising natural source for
potential antimalarial drug development. This study investigates the antimalarial effects of the
ethanol extract derived from S. alba leaves in a mouse model. To assess the antimalarial activity
of the extracts in vivo, mice were intraperitoneally injected with the Plasmodium berghei ANKA
strain, followed by daily administration of the ethanol extract from S. alba leaves for four
consecutive days. Parasitemia levels were monitored using light microscopy. The findings
revealed a significant suppression of parasitemia in malaria-infected mice treated with the ethanol
extract of S. alba leaves at a dose of 300 mg/kg BW, achieving a reduction of 77.34%. Mice
administered with 150 mg/kg BW of the ethanol extract demonstrated a suppression rate of
62.35%, while those treated with 75 mg/kg BW displayed 43.53% suppression. This study
underscores the potential antimalarial properties of the ethanol extract derived from S. alba leaves
when administered in vivo.

Article Details

How to Cite
Muhaimin, M., Latifah, N., Chaerunisaa, A. Y., Subarnas, A., Susilawati, Y., & Hirzan, R. (2024). Antiplasmodial Activity of Ethanol Extract of Sonneratia alba Leaves. Tropical Journal of Natural Product Research (TJNPR), 8(4), 6884–6890. https://doi.org/10.26538/tjnpr/v8i4.19
Section
Articles
Author Biographies

Muhaimin Muhaimin, Faculty of Pharmacy, Universitas Padjadjaran, Jl. Raya Bandung - Sumedang Km 21, Jatinangor 45363, Indonesia

Center of Herbal Study, Universitas Padjadjaran, Jl. Raya Bandung - Sumedang Km 21, Jatinangor 45363, Indonesia

Nor Latifah, Faculty of Pharmacy, Universitas Padjadjaran, Jl. Raya Bandung - Sumedang Km 21, Jatinangor 45363, Indonesia

Faculty of Pharmacy, Universitas Muhammadiyah Banjarmasin, Jalan S. Parman, Banjarmasin, 70123, Kalimantan Selatan, Indonesia

Yasmiwar Susilawati, Faculty of Pharmacy, Universitas Padjadjaran, Jl. Raya Bandung - Sumedang Km 21, Jatinangor 45363, Indonesia

Center of Herbal Study, Universitas Padjadjaran, Jl. Raya Bandung - Sumedang Km 21, Jatinangor 45363, Indonesia

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