Toxicity Evaluation with Brine Shrimp Lethality Test and Phytochemical Analysis of Some Indonesian Plant Extracts As Potential Anti-Colon Cancer Agents
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Abstract
Garlic (Allium sativum), red ginger (Zingiber officinale), turmeric (Curcuma longa), tea (Camellia
sinensis), tomato (Solanum lycopersicum), bitter melon (Momordica charantia), pearl grass
(Hedyotis corymbosa (L.) Lamk.), soybean (Glycine max), grape (Vitis venifera) and Sambiloto
(Andrographis paniculata) were studied for their anticancer potential in colon cancer. Using a
combination of these plants as promising anticancer agents still requires further exploration from
the cultivation and formulation. This research was aimed at the phytochemical analysis and
evaluation of the anticancer potential of these plants in colon cancer. The Brine Shrimp Lethality
toxicity test using Artemia salina Leach larvae was used to determine the LC50 value of the plant
extracts. Two of the ten plants with the lowest LC50 values include turmeric and ginger, with
cytotoxicity values of 15.995 ppm and 3.488 ppm, respectively.
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