Assessment of the Effect of Cashew (Anacardium occidentale L.) Nut-Supplemented Diet on Key Biochemical Indices Relevant to Cardiac Function in Cisplatin-Induced Cardiotoxic Rats
Article Sidebar
Main Article Content
Abstract
Cardiotoxicity can develop as a result of exposure to certain chemicals, poisons, or infectious agents as well as the continued use of higher doses of some medications. Natural plant foods such as cashew nut (Anacardium occidentale L.) may have free radical scavenging activity, thereby may play an important role in protecting the heart from chemotherapy-related cardiac dysfunction. In this study, the effect of cashew nut-supplemented diet on key indices relevant to cardiac function in cisplatin-induced cardiotoxic rats was evaluated. The rats were divided into six groups (n=6): rats fed a basal diet; cisplatin-induced rats fed a basal diet; cisplatin-induced rats fed a diet supplemented with processed cashew nut (10 and 20%); healthy rats fed a diet supplemented with processed cashew nut (10 and 20%) for fourteen days. Cisplatin-treated rats showed increased activities of acetylcholinesterase and butyrylcholinesterase, adenosine deaminase, monoamine oxidase, phosphodiesterase-5 and arginase activities with a concomitant decrease in levels of nitric oxide, total thiol, total antioxidant capacity and reduced glutathione, superoxide dismutase, catalase, glutathione peroxidase and glutathione-S-transferase activities both in the heart and plasma when compared with control. However, dietary supplementation with cashew nut significantly attenuated the cisplatin-evoked disturbances in the above-mentioned parameters. Also, feeding of experimental rats with cashew nut-supplemented diet for fourteen days restores significantly the heart histological alteration caused by cisplatin. Taken together, these findings imply that eating cashew nuts may represent a novel cardioprotective strategy during chemotherapy based on cisplatin. Therefore, it could be used as functional diet to prevent cardiac dysfunction caused by cisplatin.
Downloads
Article Details
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
How to Cite
References
Cross MJ, Berridge BR, Clements PJM, Cove-Smith L, Force TL, Hoffmann P, Holbrook M, Lyon AR, Mellor HR, Norris AA, Pirmohamed M, Tugwood JD, Sidaway JE, Park BK.. Physiological, pharmacological and toxicological considerations of drug-induced structural cardiac injury. Br J Pharmacol. 2015; 172(4): 957–974
Berardi R, Caramanti M, Savini A, Chiorrini S, Pierantoni C, Onofri A, Zelmira B, Mariagrazia De L, Paola M, Stefano C. State of the art for cardiotoxicity due to chemotherapy and to targeted therapies: a literature review. Crit Rev Oncol Hematol. 2013; 88:75–86.
Yousef ZR, Paul WX F, Kayvan K, Shajil C, Harald S, Noor UH M, Francisco L. Management of hepatitis C virus infection in HIV/HCV co-infected patients: Clinical review. BMC Cardiovasc Disord. 2009; 9: 37. Published online 2009 Aug 9. doi: 10.1186/1471-2261-9-37 PMCID: PMC2743643
Pai VB, Nahata MC. Cardiotoxicity of chemotherapeutic agents: incidence, treatment and prevention. Drug Saf. 2000; 22:263–302.
Deavall DG, Martin EA, Horner JM, Roberts R. Drug-induced oxidative stress and toxicity. J Toxicol. 2012; 2012:645460.
Tchounwou PB, Dasari S, Noubissi FK, Ray P., Kumar S. Advances in our understanding of the molecular mechanisms of action of cisplatin in cancer therapy. J. Exp. Pharmacol. 2021; 303-328.
Aly HA., Eid BG. Cisplatin induced testicular damage through mitochondria mediated apoptosis, inflammation and oxidative stress in rats: Impact of resveratrol. Endocr. J. 2020; 67(9): 969-980.
Wozniak K, Czechowska A, Blasiak J. Cisplatin-evoked DNA fragmentation in normal and cancer cells and its modulation by free radical scavengers and the tyrosine kinase inhibitors STI571. Chem Biol Interact. 2004; 147:309–318.
Singal, P., Li, T., Kumar, D., Danelisen, I., Iliskovic, N. Adriamycin-induced heart failure: mechanisms and modulation. Mol. cell Biochem. 2000; 207: 77-86.
Doroshow JH, Esworthy RS. The role of antioxidant defenses in the cardiotoxicity of anthracycline. In: Cancer Treatment and the Heart, ed. Muggia FM, Green MD, and Speyer JL, 1992, pp. 47–58. Johns Hopkins University Press, Baltimore, MD.
Tapsell L, Sabaté J, Martínez R, Llavanera M, Neale E, Salas-Huetos A. Novel Lines of Research on the Environmental and Human Health Impacts of Nut Consumption. Nutrients, 2023; 15(4): 955.
Ros E.. Health Benefits of Nut Consumption. Nutrients. 2010; 2(7): 652–682.
Aydar EF, Tutuncu S, Ozcelik B. (2020). Plant-based milk substitutes: Bioactive compounds, conventional and novel processes, bioavailability studies, and health effects. J. Funct. Foods, 2020; 70: 103975.
Hu FB, Stampfer MJ, Manson JE, Rimm EB, Colditz GA, Rosner BA, Speizer FE, Hennekens CH, Willett WC. . Frequent nut consumption and risk of coronary heart disease in women: prospective cohort study. BMJ. 1998; 317(7169): 1341–1345.
Albert CM, Gaziano JM, Willett WC, Manson JE.. Nut consumption and decreased risk of sudden cardiac death in the Physicians' Health Study. Arch Intern Med. 2002; 162(12):1382-7.
Vadivel V, Kunyanga CN, K. Biesalski HK.. Health benefits of nut consumption with special reference to body weight control. Nutrition. 2012; 28: 1089–1097.
Akomolafe SF, Oyeleye SI, Oboh, G. (2022). Effect of cashew (Anacardium occidentale L.) nut-supplemented diet on steroidogenic enzymes, hormonal and oxidative imbalances, and sperm parameters in cisplatin-induced reproductive toxicity in male rats. J. Food Biochem. 2022; 00: e14100.
Akomolafe SF, Olabiyi AA. Evaluation of Dietary Supplementation of Pumpkin (Cucurbita pepo L) Seed on Antioxidant Status, Hormonal Level and Sexual Behavior in Male Rats. Trop. J. Nat. Prod. Res. 2021; 5(5): 952-958.
Giusti G, Gakis C. Temperature conversion factors, activation energy, relative substrate specificity and optimum pH of adenosine deaminase from human serum and tissues. Enzyme, 1971; 12, 417–425.
Green AL. and Haughton TM. A colorimetric method for the estimation of monoamine oxidase. Biochem. J. 1961; 78, 172-175.
Ellman GL, Courtney KD, Andres V, Featherstone RM. A new and rapid colorimetric determination of acetylcholinesterase activity. Biochem. Pharmacol. 1961; 7, 88 - 95.
Oboh G, Adedayo AA, Ademosun AO, Boligon, AA. In vitro inhibition of phosphodiesterase-5 and arginase activities from rat penile tissue by two Nigerian herbs (Hunteria umbellate and Anogeissus leiocarpus). J Basic Clin Physiol Pharmacol. 2017; Doi: 10.1515/jbcpp-2016-0143.
Zhang C, Hein TW, Wang W, Chang CI, Kuo L. Constitutive expression of Arginase in microvascular endothelial cells counteracts nitric oxide mediated vasodilatory function. FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology, 2001;15, 1264–1266.
Misra HP, Fridovich I. The role of superoxide anion in the autoxidation of epinephrine and a simple assay for superoxide dismutase. J Biol Chem 1972; 247:3170–3175
Clairborne A. Catalase activity. In: Greewald AR (ed) Handbook of methods for oxygen radical research. CRC Press, Boca Raton, USA, 1995; pp 237–242
Habig WH, Pabst UJ, Jakoby WB. Glutathione-S-transferase. J Biol Chem. 1974; 249:7130–9.
Paglia DE, and Valentine WN. Studies on quantitative and qualitative characterization of erythrocyte glutathione peroxidase. J Lab Clin Med. 1967; 70:158–69.
Ellman, G. L. Tissue sulfhydryl groups. Arch. Biochem. Biophys. 1959; 82, 70–77.
Kambayashi Y, Binh T, Asakura HW. Efficient assay for total antioxidant capacity in human plasma using a 96-well microplte. J. Clin. Biochem. Nutr., 2009; 44(1): 46–51.
Hayashi I, Morishita Y, Imai K, Nakamura M, Nakachi K. and Hayashi T. High-throughput spectrophotometric assay of reactive oxygen species in serum. Mutat. Res. Genet. Toxicol. Environ., 2007; 631(1): 55–61.
Miranda KM, Espay MG, Wink DA. A rapid, simple spectrophotometric method for simultaneous detection of nitrate and nitrite. Nitric Oxide: Biol. Chem. 2001; 5: 62–71.
Jentzsch AM, Bachmann H, Fürst P, and Biesalski HK. Improved analysis of malondialdehyde in human body fluids. Free Radic. Biol. Med. 1996; 20(2): 251–6.
Lowry OH, Rosenbrough NJ, Farr AL, Randall RJ. Protein measurement with folin phenol reagent. J Biol Chem. 1951; 193:265.
Gordan R, Gwathmey JK, Xie L. Autonomic and endocrine control of cardiovascular function. World J Cardiol. 2015; 7(4): 204–214.
Rocha-Resende C, Roy A, Resende R, Ladeira MS, Lara A, de Morais Gomes ER, Prado VF, Gros R, Guatimosim C, Prado MA, Guatimosim S.. Non-neuronal cholinergic machinery present in cardiomyocytes offsets hypertrophic signals. J. Mol. Cell. Cardiol. 2012; 53: 206–216
Kakinuma Y, Akiyama T, Sato T. Cholinoceptive and cholinergic properties of cardiomyocytes involving an amplification mechanism for vagal efferent effects in sparsely innervated ventricular myocardium. FEBS J. 2009; 276: 5111–5125.
Nordstrom P, Religa D, Wimo A, Winblad B, Eriksdotter M. The use of cholinesterase inhibitors and the risk of myocardial infarction and death: a nationwide cohort study in subjects with Alzheimer's disease. Eur Heart J. 2013; 34: 2585–2591.
Lara A, Damasceno DD, Pires R, Gros R, Gomes ER. Dysautonomia due to reduced cholinergic neurotransmission causes cardiac remodeling and heart failure. Mol Cell Biol. 2010; 30: 1746–1756.
Okazaki Y, Zheng C, Li M, Sugimachi M. Effect of the cholinesterase inhibitor donepezil on cardiac remodeling and autonomic balance in rats with heart failure. J Physiol Sci. 2010; 60: 67–74.
Peart JN and Headrick JP. Adenosinergic cardioprotection: Multiple receptors, multiple pathways. Pharm. Therap. 2007; 114: 208–221.
He H, Li Y, He G, Wang Y, Zhai Y, Xie J, Zhang W, Dong Y, Lu J. The Adenosine Deaminase Gene Polymorphism Is Associated with Chronic Heart Failure Risk in Chinese. Int. J. Mol. Sci. 2014;15: 15259-15271.
Peart J, Matherne GP, Jones R, Headrick, JP. Cardioprotection with adenosine metabolism inhibitors in ischemic-reperfused mouse heart. Cardiovasc Res 2001; 52: 120−129.
Willems L, Headrick JP. Protecting murine hearts from ischaemiareperfusion using selective inhibitors of adenosine metabolism. Clin Exp Pharmacol Physiol. 2005; 32: 179−183.
Maurel A., Hernandez, C. Kunduzova O., Bompart, G. Cambon, C. Parini, A. Frances B., Age-dependent increase in hydrogen peroxide production by cardiac monoamine oxidase A in rats, Am. J. Physiol. Heart Circ. Physiol. 284 (2003) H1460–H1467.
Bianchi P. Pimentel DR. Murphy MP, Colucci WS, Parini A. A new hypertrophic mechanism of serotonin in cardiac myocytes: receptor-independent ROS generation, FASEB J. 2005; 19: 641–64.
Mialet-Perez J, Bianchi P, Kunduzova O. Parini, A. New insights on receptordependent and monoamine oxidase-dependent effects of serotonin in the heart, J. Neural Transm. 2007; 114: 823–827
Kaludercic N, Takimoto E, Nagayama T, Feng N, Lai EW, Bedja D, Chen K, Gabrielson KL, Blakely RD, Shih JC, Pacak K, Kass DA, Di Lisa F, Paolocci N. Monoamine oxidase A-mediated enhanced catabolism of norepinephrine contributes to adverse remodeling and pump failure in hearts with pressure overload, Circ. Res 2010; 106: 193–202.
Chuang L, Albert PL. Enzyme inhibition in drug discovery and development: The good and the bad. John Wiley & Sons Inc 2010.
Andrade JM, Aboy AL, Apel MA, Raseira MC, Pereira JF, Henriques AT. Phenolic composition in different genotypes of Guabiju fruits (Myrcianthes pungens) and their potential as antioxidant and antichemotactic agents. J Food Sci. 2011; 76:C1181–7.
Andrade MMJ, Passos CS, Dresch RR, Kieling-Rubio MA, Moreno PRH, Henriques AT. Chemical analysis, antioxidant, antichemotactic and monoamine oxidase inhibition effects of some pteridophytes from Brazil. Pharmacogn. Mag. 2014; 10(1): S100–S109.
Pernow J, Jung C. Arginase as a potential target in the treatment of cardiovascular disease: reversal of arginine steal? Cardiovasc. Res., 2013; 98(3): 334–343.
Romero MJ, Platt DH, Tawfik HE, Labazi M, El-Remessy AB, Bartoli M.. Diabetes-induced coronary vascular dysfunction involves increased arginase activity. Circ Res 2008;102: 95 – 102.
Cotton JM, Kearney MT, Shah AM. Nitric oxide and myocardial function in heart failure: friend or foe? Heart 2002; 88(6): 564–566.
Post H, Pieske B. 2006. Arginase: a modulator of myocardial function. Am J Physiol Heart Circ Physiol 290: H1747 – H1748
Quitter F, Figulla HR, Ferrari M, Pernow J, Jung C. Increased arginase levels in heart failure represent a therapeutic target to rescue microvascular perfusion. Clin Hemorheol Microcirc 2012 doi: 10.3233/CH-2012-1617
Boswell-Smith V, Spina D, Page CP. Phosphodiesterase inhibitors. Br J Pharmacol. 2006 ;147-252. doi: 10.1038/sj.bjp.0706495. PMID: 16402111; PMCID: PMC1760738
Knight W, Yan C. Therapeutic potential of PDE modulation in treating heart disease. Future Med Chem 2013, 5(14): 1607–1620.
Hong JH, Kwon YSK, Kim IY. Pharmacodynamics, pharmacokinetics and clinical efficacy of phosphodiesterase-5 inhibitors. Expert Opin. Drug Metab. Toxicol. 2017; 13(2): 183 – 192.
Giordano FJ. Oxygen, oxidative stress, hypoxia and heart failure. J. Clin. Invest. 2005: 115(3): 500 – 508.
Sabri A, Hughie HH, and Lucchesi PA. Regulation of hypertrophic and apoptotic signaling pathways by reactive oxygen species in cardiac myocytes. Antioxid. Redox Signal. 2003; 5:731–740
Sawyer DB, Zuppinger C, Miller TA, Eppenberger HM, Suter TM. Role of oxidative stress in myocardial hypertrophy and failure. J. Mol. Cell. Cardiol 2002; 34:379–388.
Cesselli D, Jakoniuk I, Barlucchi L, Beltrami AP, Hintze TH, Nadal-Ginard B, Kajstura J, Leri A, Anversa P. Oxidative stress-mediated cardiac cell death is a major determinant of ventricular dysfunction and failure in dog dilated cardiomyopathy. Circ. Res 2001; 89:279–286
Smigic J, Stojic I, Zivkovic V, Srejovic I, Nikolic T, Jeremic J, Sabo T, Jakovljevic V.. The effects of chronic administration of cisplatin on oxidative stress in the isolated rat heart. Ser J Exp Clin Res 2017: 1-1 DOI:10.1515/SJECR-2017-0003
Hussein A, Ahmed AA, Shouman SA, Sharawy S. Ameliorating effect of DL-α-lipoic acid against cisplatin-induced nephrotoxicity and cardiotoxicity in experimental animals. Drug Discov Ther 2012; 6(3):147-56.
Bolling BW, McKay DL, Blumberg JB. The phytochemical composition and antioxidant actions of tree nuts. Asia Pac J Clin Nutr 2010; 19(1): 117–123.
Wang J, He D, Zhang Q, Han Y, Jin S, Qi F.. Resveratrol protects against Cisplatin-induced cardiotoxicity by alleviating oxidative damage. Cancer Biother Radiopharm 2009; 24(6):675-80. doi: 10.1089/cbr.2009.0679.