PTP1B Inhibitors from Indonesian Plants and Its Structure-Activity Relationship: A Review
DOI:
https://doi.org/10.26538/tjnpr/v8i3.2Keywords:
Indonesia, plants, Structure-activity relationship, PTP1B inhibitorsAbstract
Diabetes is still a world health problem because of the large number of sufferers and from year to year shows a trend of increasing the number. Type 2 diabetes is the most common type found as well as the largest contributor to diabetes cases, with a percentage of more than 90%. To overcome this problem, more potent and efficient type 2 diabetes drugs are urgently needed. Protein tyrosine phosphatase 1B (PTP1B) is one of the enzyme targets in the discovery of new drugs for type 2 diabetes because it has an important contribution as a negative regulator in the blood sugar transport mechanism, especially in the insulin and leptin signaling pathways. Based on this role, compounds that can act as PTP1B inhibitors have great potential to be developed as new drug candidates for type 2 diabetes. Natural products derived from plants with extraordinary structural diversity are expected to provide potential PTP1B inhibitor scaffolds for developing type 2 diabetes drugs. This review focuses on the structure-activity relationship (SAR) of compounds derived from Indonesian plants that have shown PTP1B inhibitory activity to provide information about the correlation between chemical structures and PTP1B activity that can be useful for the selection of potential scaffolds for type 2 diabetes drug development.
References
Ito Y, Fukui M, Kanda M, Morishita K, Shoji Y, Kitao T, Hinoi E, Shirahase H. Therapeutic effects of the allosteric protein tyrosine phosphatase 1B inhibitor KY-226 on experimental diabetes and obesity via enhancements in insulin and leptin signaling in mice. J Pharmacol Sci. 2018; 137: 38-46.
Roden M, Shulman GI. The integrative biology of type 2 diabetes. Nature 2019; 576: 51-60.
Artasensi A, Pedretti A, Vistoli G, Fumagalli L. Type 2 diabetes mellitus: A review of multi-target drugs. Molecules 2020; 25: 1987.
International Diabetes Federation. IDF diabetes atlas 10th edition. Brussels, Belgium, 2021. https://www.diabetesatlas.org.
Singh S, Grewal AS, Grover R, Sharma N, Chopra B,Dhingra AK, Arora S, Redhu S, Lather V. Recent updates on development of protein-tyrosine phosphatase 1B
inhibitors for treatment of diabetes, obesity and related disorders. Bioorg Chem. 2022; 121: 105626.
Behl T, Gupta A, Sehgal A, Albarrati A, Albratty M, Meraya AM, Najmi A, Bhatia S, Bungau S. Exploring protein tyrosine phosphatases (PTP) and PTP-1B inhibitors in
management of diabetes mellitus. Biomed Pharmacother. 2022; 153: 113405.
Newman DJ, Cragg GM. Natural products as sources of new drugs from 1981 to 2014. J Nat Prod. 2016; 79: 629-661.
De la Torre BG, Albericio F. The pharmaceutical industry in 2019. An analysis of FDA drug approvals from the perspective of molecules. Molecules 2020; 25: 745.
Igarashi M, Ishizaki Y, Takahashi Y. New antituberculous drugs derived from natural products: Current perspectives and issues in antituberculous drug development. J Antibiot. 2018; 71: 15-25.
Truax NJ, Romo D. Bridging the gap between natural product synthesis and drug discovery. Nat Prod Rep. 2020; 37: 1436-1453.
Schetz JA. Structure-activity relationships: Theory, uses and limitations. Ref. Modul Biomed Sci. 2015. doi:10.1016/b978-0-12-801238-3.05329-0.
Bandodkar B, Shandil RK, Bhat J, Balganesh TS. Two decades of TB drug discovery efforts-What have we learned? Appl Sci. 2020; 10: 5704.
Süntar I. Importance of ethnopharmacological studies in drug discovery: role of medicinal plants. Phytochem Rev. 2020; 19: 1199-1209.
Nunes CDR, Arantes MB, Pereira SMDF, Cruz LLD, Passos MDS, Moraes LPD, Vieira IJC, Oliveira DBD. Plants as sources of anti-inflammatory agents. Molecules 2020; 25:
Thomford NE, Senthebane DA, Rowe A, Munro D, Seele P, Maroyi A, Dzobo K. Natural products for drug discovery in the 21st century: Innovations for novel drug discovery. Int J Mol Sci. 2018; 19: 1578.
Salmerón-Manzano E, Garrido-Cardenas JA, ManzanoAgugliaro F. Worldwide research trends on medicinal plants. Int J Environ Res Public Health 2020; 17: 3376.
Weller MG. A unifying review of bioassay-guided fractionation, effect-directed analysis and related techniques. Sensors 2012; 12: 9181-9209.
Gorlenko CL, Kiselev HY, Budanova EV, Zamyatnin AA, Ikryannikova LN. Plant secondary metabolites in the battle of drugs and drug-resistant bacteria: New heroes or worse clones of antibiotics? Antibiotics 2020; 9: 170.
Atanasov AG, Waltenberger B, Pferschy-Wenzig EM, Linder T, Wawrosch C, Uhrin P, Temml V, Wang L, Schwaiger S, Heiss EH, Rollinger JM, Schuster D, Breuss JM, Bochkov V, Mihovilovic MD, Kopp B, Bauer R, Dirsch VM, Stuppner H. Discovery and resupply of pharmacologically active plant-derived natural products: A review. Biotechnol Adv. 2015; 33: 1582-1614.
Che CT, Zhang H. Plant natural products for human health. Int J Mol Sci. 2019; 20: 2-5.
Veeresham C. Natural products derived from plants as a source of drugs. J Adv Pharm Technol Res. 2012; 3: 200-201.
Majumder R, Das CK, Mandal M. Lead bioactive compounds of Aloe vera as potential anticancer agent. Pharmacol Res. 2019; 148: 104416.
Kessler A, Kalske A. Plant secondary metabolite diversity and species interactions. Annu Rev Ecol Evol Syst. 2018; 49: 115-138.
Nguyen DT, To DC, Tran TT, Tran MH, Nguyen PH. PTP1B and α-glucosidase inhibitors from Selaginella rolandiprincipis and their glucose uptake stimulation. J Nat Med. 2021; 75: 186-193.
Nguyen PH, Tuan HN, Hoang DT, Vu QT, Pham MQ, Tran MH, To DC. Glucose uptake stimulatory and PTP1B inhibitory activities of pimarane diterpenes from Orthosiphon stamineus Benth. Biomolecules 2019; 9: 859.
Ren YM, Zhang R, Feng Z, Ke CQ, Yao S, Tang C, Lin L, Ye Y. Macrocephatriolides A and B: Two guaianolide trimers from Ainsliaea macrocephala as PTP1B inhibitors and insulin sensitizers. J Org Chem. 2021; 86: 17782-17789.
Zhang Z, Shang ZP, Jiang Y, Qu ZX, Yang RY, Zhang J, Lin YX, Zhao F. Selective inhibition of PTP1B by new anthraquinone glycosides from Knoxia valerianoides. J Nat Prod. 2022; 85: 2836-2844.
Panggabean JA, Adiguna SP, Murniasih T, Rahmawati SI, Bayu A, Putra MY. Structure–activity relationship of cytotoxic natural products from Indonesian marine sponges. Rev Bras Farmacogn. 2022; 32: 12-38.
Saifudin A, Tanaka K, Kadota S, Tezuka Y. Chemical constituents of Blumea balsamifera of Indonesia and their protein tyrosine phosphatase 1B inhibitory activity. Nat Prod Commun. 2012; 7: 815-818.
Abdjul DB, Yamazaki H, Maarisit W, Losung F, Rotinsulu H, Wewengkang DS, Sumilat DA, Namikoshi M. Eudesmanolide sesquiterpenes and protein tyrosine phosphatase 1B inhibitory ent-kaurene diterpenes from aerial parts of Indonesian Wedelia prostata. Phytochem Lett. 2017; 20: 191-195.
Saifudin A, Kadota S, Tezuka Y. Protein tyrosine phosphatase 1B inhibitory activity of Indonesian herbal medicines and constituents of Cinnamomum burmannii and Zingiber aromaticum. J Nat Med. 2013; 67: 264-270.
Abdjul DB, Yamazaki H, Kanno S, Kirikoshi R, Tomizawa A, Takahashi O, Maarisit W, Losung F, Rotinsulu H, Wewengkang DS, Sumilat DA, Kapojos MM, Namikoshi M.
Absolute structures of wedelolide derivatives and structure–activity relationships of protein tyrosine phosphatase 1B inhibitory ent-kaurene diterpenes from aerial parts of Wedelia spp. collected in Indonesia and Japan. Chem Pharm Bull. 2018; 66: 682-687.
Saifudin A, Lallo SA, Tezuka Y. The potent inhibitors of protein tyrosine phosphatase 1B from the fruits of Melaleuca leucadendron. Pharmacognosy Res. 2016; 8: 38-41.
Kapojos MM, Abdjul DB, Yamazaki H, Yagi A, Uchida R. Screening of Indonesian edible plants for bioactive constituents and a new protein tyrosine phosphatase 1B
inhibitory acylbenzene derivative from leaves of Indonesian Syzygium polyanthum. Chem Pharm Bull. 2020; 68: 903-906.
Abdjul DB, Yamazaki H, Maarisit W, Rotinsulu H, Wewengkang DS, Sumilat DA, Kapojos MM, Losung F, Ukai K, Namikoshi M. Oleanane triterpenes with protein tyrosine phosphatase 1B inhibitory activity from aerial parts of Lantana camara collected in Indonesia and Japan. Phytochemistry 2017; 144: 106-112.
Saifudin A, Tanaka K, Kadota S, Tezuka Y. Protein tyrosine phosphatase 1B (PTP1B)-inhibiting constituents from the leaves of Syzygium polyanthum. Planta Med. 2012; 78: 1378-1381.
Abdjul DB, Yamazaki H, Maarisit W, Kirikoshi R, Takahashi O, Losung F, Kapojos MM, Namikoshi M.Protein tyrosine phosphatase 1B inhibitory components and a new unique N-alkylamide derivative with an endoperoxide bridge from aerial parts of Indonesian Spilanthes paniculata. Phytochem Lett. 2018; 24: 71-74.
Zhang YN, Zhang W, Hong D, Shi L, Shen Q, Li JY, Li J, Hu LH. Oleanolic acid and its derivatives: New inhibitor of protein tyrosine phosphatase 1B with cellular activities. Bioorganic Med Chem. 2008; 16: 8697-8705.
Sumilat DA, Yamazaki H, Kanno SI, Saito R, Watanabe Y, Namikoshi M. Biphenyl ether derivatives with protein tyrosine phosphatase 1B inhibitory activity from the freshwater fungus Phoma sp. J Antibiot.2017; 70: 331-333.
Yamazaki H, Takahashi K, Iwakura N, Abe T, Akaishi M, Chiba S, Namikoshi M, Uchida R. A new protein tyrosine phosphatase 1B inhibitory α-pyrone-type polyketide from Okinawan plant-associated Aspergillus sp. TMPU1623. J Antibiot. 2018; 71: 745-748
Published
How to Cite
Issue
Section
License
Copyright (c) 2024 Tropical Journal of Natural Product Research (TJNPR)
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
