Ethnobotanical Study of Potentially Toxic Plants of Fez-Meknes Region, Eastern Middle Atlas, Morocco
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Abstract
Medicinal plants have been used for therapeutic purposes since ancient times. These plants are generally perceived as safe, but they could also be toxic. The present study aims to undertake a survey of the nature, mode of application, and toxic effect of medicinal plants used in Fez-Meknes region, Eastern Middle Atlas, Morocco. An ethnobotanical survey was conducted from January 2020 to August 2021. The method employed a semi-structured questionnaire with open-ended questions on the uses, mode of application, and effects of the plants. The data obtained were statistically analyzed. Parameters such as Family use value (FUV), Use value (UV), Fidelity level (FL), and Informant agreement ratio (IAR) were obtained. From the survey, 59 potentially toxic plants, distributed across 33 families were documented. Concerning the uses of these plants, 31% of the respondents claimed that the plants are for cosmetic purposes, 23% claimed they are for minor illnesses, 15% claimed they are for chronic diseases, another 15% claimed they are ineffective, while 8% each claimed that they are for acute illnesses and other uses. For the disease categories, the result showed that the IAR values ranged from 0.8 to 0.96. The disease with the highest IAR value was hair loss (IAR = 0.96), followed by rheumatism (IAR = 0.95). The findings from this study have highlighted the potentially poisonous plants in the Fez-Meknes region. Further phytochemical and pharmacological studies on acute, sub-acute, and chronic plant toxicity are needed to determine the acceptable dose (LD50), the most appropriate method for optimal use.
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Talukdar SN, Rahman MB, Paul S. A Review on Barleria prionitis: Its Pharmacognosy, Phytochemicals and Traditional Use. J. Ad Med Phar. Sci. Published online September 19, 2015:1-13. doi:10.9734/JAMPS/2015/20551
Zaman W, Ye J, Saqib S, Yun L, Shan Z, Hao D, Chen Z, Xiao P. Predicting potential medicinal plants with phylogenetic topology: Inspiration from the research of traditional Chinese medicine. J.Ethno. 2021; 281:114515.
doi: 10.1016/j.jep.2021.114515
Neergheen-Bhujun VS. Underestimating the Toxicological Challenges Associated with the Use of Herbal Medicinal Products in Developing Countries. BioMed Rese Inte. 2013;2013: e804086. doi:10.1155/2013/804086
Neffati M, Shgaier M. Development and valorization of aromatic and medicinal plants (AMP) at the level of dezeritic zones in the MENA region. OSS; 2014. Accessed April 3, 2022. https://onagri.home.blog/2021/02/03/developmentand-valorization-the-plants-aromatic-and-medicinals-pamat-level-of-the region-dezert-of-the-zone-mena/
Alistiqsa F, Bouassab A, Physico-chemical Laboratory of Materials, Natural Substances and Environment (LAMSE), faculty of science and technology of Tangier, Abdelmalek Essaadi University, Morocco., Allouch M, Laboratory of
Materials and Valorization of Resources (LMVR) faculty of science and technology of Tangier, Abdelmalek Essaadi University, Morocco. Ethnobotanical study of medicinal plants from the tangier region case of hjar nhal and melloussa. IJAR. 2017;5(11):310-322. doi:10.21474/IJAR01/5772
Palombo EA. Phytochemicals from traditional medicinal plants used in the treatment of diarrhoea: modes of action and effects on intestinal function. Phytother Res. 2006;20(9):717-724. doi:10.1002/ptr.1907
El Khomsi M, Kara M, Hmamou A, Assouguem A, Omkulthom A, Saleh A, Sezail E, Hafize F, Driss Hmouni. In Vitro Studies on the Antimicrobial and Antioxidant
Activities of Total Polyphenol Content of Cynara humilisfrom Moulay Yacoub Area (Morocco). Plts. 2022;11(9):1200. doi:10.3390/plants11091200
Kara M, Assouguem A, Abdou R. Z, Bahhou J. Phytochemical Content and Antioxidant Activity of Vinegar Prepared from Four Apple Varieties by Different Methods. TJNPR. 2021;5(9):1578-1585. doi:10.26538/tjnpr/v5i9.9
Jamal Bellakhdar. Medicinal Plants in the Maghreb and precise basic care of modern phytotherapy.; 2006. Accessed June 17, 2022. https://qitab.ma/fr/science-andtechnique/plants-medicinal-at-maghreb-and- care - from -base- precise - from - phytotherapy -modern.
Bernard Boullard. Medicinal plants from around the world. Beliefs and realities. - Bernard Boullard.; 2001. Accessed June 16, 2022. https://www.decitre.fr/livres/plantsmedicinal- from - world -9782843711176.html
Flesch F. Poisoning of plant origin. EMC - Medicine. 2005;2(5):532-546. doi: 10.1016/j.emcmed.2005.08.001
Bourhia M, Bari A, Ali SS, Benbacer L, Khlil N. Phytochemistry and toxicological assessment of Bryonia dioica roots used in north-African alternative medicine. Op Che. 2019;17(1):1403-1411. doi:10.1515/chem-2019-0150
Alves RR, Rosa IM. Biodiversity, traditional medicine and public health: where do they meet? J. Ethn.Ethn. 2007;3(1):14. doi:10.1186/1746-4269-3-14
Lfitat A, ed-dahmani I, Bousraf F, et al. Antifungal Activity of the Argan Kernels Extracts and the Heat Treatment Effect on the Activity Variation. Indo Food Nutr Pro. 2023;20:10. doi:10.22146/ifnp.79710
Yassir B, Cadi M, Eljaoudi R, Laatiris A, Bouklouze A, Cherrah Y. Poisonous plants in Morocco. Med Mag.2012;196.
General Directorate of Local Authoritie G. Monograph of the Fez-Meknes region. Published online July 25, 2018. Accessed April 3, 2022. http://www.region-fesmeknes.ma/fr/publications/monographie-de-la-region-fesmeknes/
Sreekeesoon DP, Mahomoodally MF. Ethnopharmacological analysis of medicinal plants and animals used in the treatment and management of pain in Mauritius. J. Ethno. 2014; 157:181-200. doi: 10.1016/j.jep.2014.09.030
Vitalini S, Iriti M, Puricelli C, Ciuchi D, Segale A, Fico G. Traditional knowledge on medicinal and food plants used in Val San Giacomo (Sondrio, Italy)-an alpine ethnobotanical study. J;Ethno2013;145(2):517 -529.
doi: 10.1016/j.jep.2012.11.024
Ouédraogo K, Dimobe K, Zerbo I, Etongo D, Zare A, Thiombiano A. Traditional knowledge and cultural importance of Gardenia erubescens Stapf & Hutch. in
Sudanian savanna of Burkina Faso. J. ethn eth. 2019;15(1):1-14.
Sulaiman, Shah S, Khan S, Bussmann, R. W., Ali, M., Hussain, D., Hussain, W. Quantitative Ethnobotanical Study of Indigenous Knowledge on Medicinal Plants Used by the Tribal Communities of Gokand Valley, District Buner,
Khyber Pakhtunkhwa, Pakistan. Plts. 2020;9(8):1001. doi:10.3390/plants9081001
El Khomsi M, Dandani Y, Chaachouay N, Hmouni D. Ethnobotanical study of plants used for medicinal, cosmetic, and food purposes in the region of Moulay Yacoub, Northeast of Morocco. J. Phar. Phar Res. 2022;10(1):13-29.
Chaachouay N, Benkhnigue O, Fadli M, El Ibaoui H, Zidane L. Ethnobotanical and ethnopharmacological studies of medicinal and aromatic plants used in the treatment of metabolic diseases in the Moroccan Rif. Hey. 2019;5(10): e02191. doi: 10.1016/j.heliyon. 2019.e02191
Milenge Kamalebo H, Nshimba Seya Wa Malale H, Masumbuko Ndabaga C, Degreef J, De Kesel A. Uses and importance of wild fungi: traditional knowledge from the
Tshopo province in the Democratic Republic of the Congo. J. Eth Ethn. 2018;14(1):13. doi:10.1186/s13002-017-0203-6
Rohman F, Lestari SR, Utomo DH, Juma Y, Arifah SN, Annisa Y. The utilization of plant diversity by Tengger Tribe around Bromo Tengger Semeru National Park, East Java, Indonesia. In: IOP Conference Series: Earth and Environmental Science. Vol 276. IOP Publishing; 2019:012042.
Benítez G, González-Tejero MR, Molero-Mesa J. Pharmaceutical ethnobotany in the western part of Granada province (southern Spain): Ethnopharmacological synthesis. J. Ethno. 2010;129(1):87-105.
Savo V, Giulia C, Maria GP, David R. Folk phytotherapy of the amalfi coast (Campania, Southern Italy). J. Ethn. 2011;135(2):376-392.
Prabhu S, Vijayakumar S, Yabesh JEM, Ravichandran K, Sakthivel B. Documentation and quantitative analysis of the local knowledge on medicinal plants in Kalrayan hills of Villupuram district, Tamil Nadu, India. J. Ethno. 2014; 157:7-20. doi: 10.1016/j.jep.2014.09.014
Lin J, Puckree T, Mvelase TP. Anti-diarrhoeal evaluation of some medicinal plants used by Zulu traditional healers. J.Ethn. 2002;79(1):53-56.
Jadid N, Kurniawan E, Himayani CES, Andriyani, Prasetyowati, I., Purwani, K. I., Wirdhatul M, Dewi H,Tjahjaningrum, I. T. D. An ethnobotanical study of
medicinal plants used by the Tengger tribe in Ngadisari village, Indonesia. PLOS ONE. 2020;15(7): e0235886. doi: 10.1371/journal.pone.0235886
Kassa Z, Asfaw Z, Demissew S. Ethno-ecological study of medicinal and wild edible plants in Sheka Zone, Southern Nations, Nationalities and Peoples Regional State, Ethiopia. Trop Plant Res. 2020; 7:65-75.
Kayani S, Ahmad M, Sultana S, Khan SZ, Zafar M, Yaseen, G, Manzoor H, Bibi, T. Ethnobotany of medicinal plants among the communities of Alpine and Sub-alpine regions of Pakistan. J.ethn. 2015; 164:186-202.
Malik K, Ahmad M, Bussmann RW, Akash T, Riaz U, Ali S. A, Abdelaaty A. S, Neelam R, Muhammad Z, Shazia S, Syed N. S. Ethnobotany of Anti-hypertensive Plants Used in Northern Pakistan. Fr. Ph. 2018;9. Accessed November 3,
https://www.frontiersin.org/articles/10.3389/fphar.2018.00789
Shaheen H, Qaseem MF, Amjad MS, Bruschi P. Exploration of ethno-medicinal knowledge among rural communities of Pearl Valley; Rawalakot, District Poonch Azad Jammu and Kashmir. PloS one. 2017;12(9): e0183956.
Benlamdini N, Elhafian M, Rochdi A, Zidane L. Floristic and ethnobotanical study of the medicinal flora of the Eastern High Atlas (Haute Moulouya). J. app. bios. 2014; 78:6771-6787.
Najem M, Bachri L, Bouiamrine EH, Ibijbijen J, Nassiri L. Overview of some medicinal poisonous plants: The case of the central Middle Atlas - Maroc Overview of some toxic plants for medicinal use: the case of the central Middle Atlas – Morocco. Ethno. Re. Appl. 2020;19. doi:10.32859/era.19.37.1-39
Najem M, Harouak H, Ibijbijen J, Nassiri L. Oral disorders and ethnobotanical treatments: A field study in the central Middle Atlas (Morocco). Hel. 2020;6(8): e04707. doi: 10.1016/j.heliyon. 2020.e04707
Farkhondeh T, Kianmehr M, Kazemi T, Samarghandian S, Khazdair M. Toxicity effects of Nerium oleander, basic and clinical evidence: A comprehensive review. Hum Exp Toxicol. 2020;39(6):773-784. doi:10.1177/0960327120901571
Najem M, Belaidi R, Slimani I, Bouiamrine EH, Ibijbijen J, Nassiri L. Traditional pharmacopoeia of the Zerhoun region - Morocco - : Ancestral knowledge and risks of toxicity. Int J Bio Chem Sci. 2019;12(6):2797. doi:10.4314/ijbcs. v12i6.25
Lahsissene H, Kahouadij A, Tijane M, Hseini S. Catalogue of medicinal plants used in the zaër region (western morocco). lejeunia. Published online January 1, 2009. Accessed January 2, 2024. https://popups.uliege.be/0457-4184/index.php?id=710
Bouabid K, Lamchouri F, Toufik H, Faouzi MEA. Phytochemical investigation, in vitro and in vivo antioxidant properties of aqueous and organic extracts of toxic plant: Atractylis gummifera L. J.Ethn. 2020; 253:112640. doi:
1016/j.jep.2020.112640
Arlt VM, Stiborova M, Schmeiser HH. Aristolochic acid as a probable human cancer hazard in herbal remedies: a review. Mutagenesis. 2002;17(4):265-277.
doi:10.1093/mutage/17.4.265
Effects of Poisonous Plants on Livestock - 1st Edition. Accessed January 3, 2024. https://shop.elsevier.com/books/effects-of-poisonousplants-on-livestock/keeler/978-0-12-403250-7
Noble MJ, Hedberg K, Hendrickson RG. Acute cannabis toxicity. Cl. Tox. 2019;57(8):735-742. doi:10.1080/15563650.2018.1548708
da Silva MGC, Amorim RNL, Câmara CC, Fontenele Neto JD, Soto-Blanco B. Acute and Sub-Chronic Toxicity of Aqueous Extracts of Chenopodium ambrosioides Leaves in Rats. J. Med.Food.2014;17(9):979-984. doi:10.1089/jmf.2013.0134
Abdellatif AG. A toxicological study of ecballium elaterium plant in mice. Published online August 17, 2023. doi:10.5281/ZENODO.8257097
S S, Bedda A, Mahdeb N, Bouzidi A. Acute Toxicity study on Citrullus colocynthis fruit methanol extract in Albino rats. J App Pharm Sci. 2013;3,(6):088-093. doi:10.7324/JAPS.2013.3614
Teke: Acute and subacute toxicities of African medicinal... -Google Scholar. Accessed January 3, 2024. https://scholar.google.com/scholar_lookup?title=Acute%20and%20subacute%20toxicities%20of%20African%20medicial%20plants&publication_year=2014&author=G.N.%20Teke&author=V.%20Kuete
Erhirhie EO, Ilodigwe EE. Six months chronic toxicity of Dryopteris filix –mas (L.) Schott ethanol leaf extract on Wistar rats. J. M He,. 2022;13(2):67-75.
doi:10.30495/medherb.2022.697685
Bustanji Y. Cytotoxic effect of Mercurialis annua L. methanolic extract on six human solid cancer cell lines. Sci Res Essays. 2012;7(37). doi:10.5897/SRE12.545
Franke H, Scholl R, Aigner A. Ricin and Ricinus communis in pharmacology and toxicology-from ancient use and “Papyrus Ebers” to modern perspectives and “poisonous plant of the year 2018.” Nau-Sc’s Ar. Pharm. 2019;392(10):1181-1208. doi:10.1007/s00210-019-01691-6
Hmidouche O, Bouftini K, Chafik A, Sara K, Rachid H, Rahmi A, Mimouni M, Maarouf E, Zaakour F, Nmila R, Khouchlaa A. Ethnomedicinal Use, Phytochemistry,
Pharmacology, and Toxicology of Euphorbia resinifera O. Berg. (B): A Review. J. Zoo. Bot. Gar. 2023;4(2):364-395. doi:10.3390/jzbg4020029
Kim DG, Lee J, Kim W, An H, Lee J H, Chang J, Kang S,Song Y, Jeon Y, Jin J. Assessment of General Toxicity of the Glycyrrhiza New Variety Extract in Rats. Pls. 2021;10(6):1126. doi:10.3390/plants10061126
Ouzir M, El Bairi K, Amzazi S. Toxicological properties of fenugreek (Trigonella foenum graecum). Fo. Chem.Tox. 2016;96:145-154. doi:10.1016/j.fct.2016.08.003
Lahlimi-Alami Q, Layachi R, Hassikou R, Benjelloun J, Guennoun N, Zaid Y, Bouzroud S. Anticandidosic Activity and Acute Toxicity of Quercus Suber L. Bark Extracts. BIOL; 2021. doi:10.20944/preprints202109. 0117.v1
Nencini C, Galluzzi P, Pippi F, Menchiari A, Micheli L. Hepatotoxicity of Teucrium chamaedrys L. decoction: role of difference in the harvesting area and preparation method. In J Phar. 2014;46(2):181-184. doi:10.4103/0253-7613.129313
Mohamed GS. Toxicity of Basil (Ocimum basilicum L.) and Rosemary (Rosmarinus officinali L.) extracts on Tribolumconfusum (DuVal) (Coleoptera:Teneberionidae). J. Phyt Dise Manag. Published online July 6, 2015:27-33. Accessed
January 3, 2024. https://ppmj.net/index.php/ppmj/article/view/40
Rhaimi S, Brikat S, Lamtai M, Ouhssine M. Acute Oral Toxicity and Neurobehavioral Effects of Salvia officinalis Essential Oil in Female Wistar Rats. AAVS. 2023;11(4). doi:10.17582/journal.aavs/2023/11.4.654.662
Sbayou H, Talbi H, Talha I, Amghar S, Hilali A. Evaluation of the genotoxicity of essential oil from Origanum compactum benth. In human lymphocytes. A J Phar Cli l Re. Published online October 1, 2016:274-276.
doi:10.22159/ajpcr. 2016.v9s2.13743
Arantes SM, Piçarra A, Guerreiro M, Salvador C, Candeias F, Caldeira A T, Martins M R Toxicological and pharmacological properties of essential oils of Calamintha nepeta, Origanum virens and Thymus mastichina of Alentejo
(Portugal). F Ch Tox. 2019; 133:110747. doi: 10.1016/j.fct.2019.110747
Nardjis S, Samir T, Noureddine S. Toxicity and physiological effects of essential Oil from Lavandula angustifolia (M.) against Rhyzopertha dominica (F.)
(Coleoptera: Bostrichidae) adults. J.Ent Resh. 2021;45(suppl):929-936. doi:10.5958/0974-4576.2021.00144.4
Mahmoud S, Lotfy J, Adbel-Hamid A, Abdou R, Elhady K. Toxicological Studies on the Sinai Plant Urginea Maritima (Scilla) in Albino Rats 2. SCVMJ. 2022;0(0):0-0. doi:10.21608/scvmj.2022.158439.1100
Brvar M, Koželj G, Možina M, Bunc M. Acute poisoning with autumn crocus (Colchicum autumnale L.). Wien Klin Wochenschr. 2004;116(5):205-208.
doi:10.1007/BF03040489 document.pdf.
Loomis: Essential of Toxicology Edisi 3 - Google Scholar. Accessed January 4, 2024. https://scholar.google.com/scholar_lookup?title=Essential%
of%20toxicology&publication_year=1968&author=T.A.%20Loomis
Miao X, Zhang X, Yuan Y, Yali Z, Jian G, Nianxin K, Xinkui L, Jiarui W, Yonggang L, Peng T. The toxicity assessment of extract of Peganum harmala L. seeds in Caenorhabditis elegans. BMC Co Med The. 2020;20(1):256.
doi:10.1186/s12906-020-03051-x
11-olive_leaves_toxicity_in_rats.pdf.
Shi R, Zhang C, Gong X, Yang M, Ji M, Jiang L, Marco L, Ruyu Y, Li M. The genus Orobanche as food and medicine: An ethnopharmacological review. J. Eth. 2020; 263:113154. doi: 10.1016/j.jep.2020.113154
Benninger J, Schneider HT, Schuppan D, Kirchner T, Hahn EG. Acute hepatitis induced by greater celandine (Chelidonium majus). Gastroenterology. 1999;117(5):1234-1237. doi:10.1016/S0016-5085(99)70410-5
Chemistry, biological activities and toxic effects of alkaloidal constituents of genus Delphinium - A mini review. Accessed January 6, 2024.
http://herbmedpharmacol.com/Article/jhp-39135
Ibrar M, Samreen U, Barkatullah, Roohullah. Phytochemical screening and evaluation of cytotoxic and phytotoxic effects of ranunculus muricatus L. | Pa. J.Pl Sci | EBSCOhost. Published January 1, 2012. Accessed January 7, 2024.
https://openurl.ebsco.com/contentitem/gcd:83236136?sid=ebsco:plink:crawler&id=ebsco:gcd:83236136
Pourbakhsh H, Taghiabadi E, Abnous K, Hariri AT, Hosseini M, Hosseinzadeh H. Effect of Nigella sativa fixed oil on ethanol toxicity in rats. Iran J Basic Med Sci. 2014;17(12).
Eskandarzadeh M, Esmaeili A, Nikbakht M R, Yukio H, Yuri N S, Javad G Y, Hassan R, Javad K F. Genus Rubia: Therapeutic Effects and Toxicity: A Review.
Nadia N, Allouni R, Attafi K, Bouhouhou S, Bouzidi A. Acute and subacute toxicity of Ruta montana extract on female rats: effect on liver and kidney. Published online November 29, 2022. Accessed January 6, 2024.
http://depot.umc.edu.dz/handle/123456789/14354
Ogunmoyole T, Adeyeye RI, Olatilu BO, Akande OA, Agunbiade OJ. Multiple organ toxicity of Datura stramonium seed extracts. Toxicology Reports. 2019; 6:983-989. doi: 10.1016/j.toxrep.2019.09.011
Rahat M, Habbachi S, Samai I, Habbachi W, Bouzar A, Benhissen S, Tahraoui A. Evaluation of the Toxic Effects of Aqueous Extracts of Solanum Nigrum L. (Solanaceae) on the Mortality and Development of Drosophila Melanogaster
(Diptera: Drosophilidae). J. Bio Man. 2021;8(4).
https://corescholar.libraries.wright.edu/jbm/vol8/iss4/15
Piccillo GA, Mondati EGM, Moro PA. Six clinical cases of Mandragora autumnalis poisoning: diagnosis and treatment. Eur J. Em.Med. 2002;9(4):342. Accessed January 7, 2024. https://journals.lww.com/euroemergencymed/abstract/2002/12000/six_clinical_cases_of_mandragora_autumnalis.10.aspx
Shanker K, Pathak NKR, Trivedi VP, Chansuria JPN, Pandey VB. An evaluation of toxicity of Taxus baccata Linn. (Talispatra) in experimental animals. J. Ethno. 2002;79(1):69-73. doi:10.1016/S0378-8741(01)00357-9