Effect of Momordica charantia Leaf Extract on Female Fertility and Foetal Well-Being in Sprague-Dawley Rats

Bolarinwa K. Subair1*, Omobolanle E. Ade-Ademilua1,2, Abraham A. Osinubi3
1Department of Botany, Faculty of Science, University of Lagos, Akoka, Lagos, Nigeria
2African Center of Excellence for Drug Research, Herbal Medicine Development and Regulatory Science (ACEDHARS), University of Lagos, Nigeria
3Department of Anatomy, College of Medicine, University of Lagos, Nigeria

Corresponding Author: [email protected]; Tel: +234 8023046207
Recieved Date: 23 September 2022; Accepted Date: 16 October 2022; Published Date: 01 November
Subair BK, Ade-Ademilua OE, Osinubi AA. Effect of Momordica charantia Leaf Extract on Female Fertility and Foetal Well-Being in Sprague-Dawley Rats. Trop J Nat Prod Res. 2022; 6(10):1719-1722. http://www.doi.org/10.26538/tjnpr/v6i10.27

 © 2022 Subair et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Infertility is a public health issue and women are often blamed for the childlessness of a couple. Solution is sort, sometimes from traditional medicines usually lacking scientific proof of efficacy. This research was aimed at investigating the effect of Momordica charantia leaf extract on female fertility and the well-being of the conceived fetuses. Momordica charantia has been utilized traditionally to treat various ailments with reported biological activities. There is however a dearth of knowledge on the effects of its leaf on female fertility and foetal well-being. Ethanol extract of M. charantia leaf (McL) was administered orally to cyclic Sprague-Dawley (S-D) rats at 100 mg/kg in pre-mating treatment for 14-17 days. Fertility index increased by 20%, number of implantation sites and live fetuses also increased. Foetal weight and crown-rump length in McL group were significantly (p < 0.05) higher than control with no physical malformations observed. This study suggests that pre-mating administration of Momordica charantia leaf extract to Sprague-Dawley rats confers pro-fertility and pro-implantation activities without foetal death or intrauterine growth restrictions at the dose administered.

Keywords: Momordica charantia, Pre-mating treatment, Female infertility, Foetal measurement
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ISSN: 2616-0684 (Print)
ISSN: 2616-0692 (Online)
DOI: 10.26538/tjnpr
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