Mangosteen Peel Extract Increases Transforming Growth Factor-Beta in the Wound Healing Process

Natasya O. Putri1, Kurnia R. Mujiono1, Andra Rizqiawan2*, Raden Soesanto2
1Undergraduate Program, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia. 
2Department of Oral and Maxillofacial Surgery, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia

Corresponding Author: [email protected]; Tel: +62-859-3113-0110
Recieved Date: 23 September 2022; Accepted Date: 10 October 2022; Published Date: 01 November
Putri NO, Mujiono KR, Rizqiawan A, Soesanto R. Mangosteen Peel Extract Increases Transforming Growth Factor-Beta in the Wound Healing Process. Trop J Nat Prod Res. 2022; 6(10):1660-1662.
© 2022 Putri et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Transforming growth factor-beta, obtained from mangosteen peel extract, is one of the natural ingredients that can aid in wound healing. It contains antibacterial and anti-inflammatory properties that help accelerate the inflammatory phase so that the proliferative phase can begin immediately. The anti-inflammatory properties in mangosteen peel can bind to factor-?B receptor activator ligands, which can induce osteoclast formation and bone resorption. This study determined the effect of mangosteen peel extract on transforming growth factor-beta expression after tooth extractions of Wistar rats. Six healthy male Wistar rats weighing 150–200 gm were used in this study. The animals were divided into a control group and a treatment group. Both groups had their teeth extracted, but only the treatment group was given mangosteen peel extract at a dose of 300 mg per-oral, three times a day. Following this, the animals were sacrificed, and a specimen of their mandibles was taken to make immunohistochemical staining using the Novocastra detection system and chromogenic detection. Transforming growth factor-beta expression was calculated by selecting the majority of positive visual fields and observation with the OLYMPUS BX 41 series, DP-70 digital camera, and OLYSIA software. Transforming growth factor-beta expression increased after oral administration of mangosteen peel extract on the extraction wounds of Wistar rats in the treatment group. The results indicate that administration of mangosteen peel extract on the extracted teeth of Wistar rats can increase the expression of transforming growth factor-beta on the third day after extraction.

Keywords: Mangosteen peel extract, Medicine, Wound healing, TGF-?, Tooth extraction
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ISSN: 2616-0684 (Print)
ISSN: 2616-0692 (Online)
DOI: 10.26538/tjnpr
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