Flavonoids Exhibit Potential Antagonistic Activity Against Platelet-Activating Factor (PAF) Receptor

Noraziah Nordin_a*, Adib A. Abdullahb, Mohd F. A. Ghania

aDepartment of Basic Medical Sciences 1, Faculty of Medicine & Health Sciences, Universiti Sains Islam Malaysia, 71800, Nilai, Negeri Sembilan, Malaysia
bDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, 

Corresponding Author: [email protected]; Tel: +606-7985002
Recieved Date: 11 May 2022; Accepted Date: 19 October 2022; Published Date: 01 November
Nordin N, Abdullah AA, Ghani MFA. Flavonoids Exhibit Potential Antagonistic Activity Against Platelet-Activating Factor (PAF) Receptor. Trop J Nat Prod Res. 2022; 6(10):1626-1631. http://www.doi.org/10.26538/tjnpr/v6i10.11

© 2022 Nordin et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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The platelet-activating factor receptor (PAFR) has been a therapeutic target for platelet-activating factor (PAF)-mediated diseases. The pathophysiological condition is triggered by the interaction of PAF agonist. The discovery of PAF antagonists from natural flavonoids could be promising candidates for treating PAF-mediated diseases. Flavonoids that exist in most edible plants possess good health benefits for the human body. The study aimed to investigate the ability of three flavonoids (apigenin, galangin and fisetin) for molecular docking and dynamic simulations into PAFR protein. The PAFR-flavonoid complex binding affinities and interactions were assessed through molecular docking and dynamic simulations. Results found that all flavonoids significantly have a good binding affinity, ranging from - 9.1 to - 8.9 kcalmol-1. The stability of these flavonoids was also achieved in a 30 ns simulation. Four critical residues were detected in all PAFR-flavonoids complexes (Phe97, Phe98, Thr101 and Leu279) from the analysis of MMGBSA binding free energy. Interactions of van der Waals and electrostatic were seen by individual key residues of PAFR for the free energy contribution of ligands binding. All flavonoids showed promising anti-PAF candidate to be developed in the future.

Keywords: Methylglyoxal, AGEPs, Advanced glycation end products, Glutathione, Magnesium, Ubiquinone.
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ISSN: 2616-0684 (Print)
ISSN: 2616-0692 (Online)
DOI: 10.26538/tjnpr
Index Copernicus Value (ICV) for 2017: 59.83
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