Isolation and Evaluation of Anti-Mycobacterial Activity of Alkaloid Compounds from Marine Invertebrate Sponge Haliclona sp.

Wilmar Maarisit1*, Sonny D. Untu2, Yessie K. Lengkey2, Jeane Mongi1, Jabes W. Kanter1, Douglas N. Pareta1, Chistel N. Sambou1, Silvana L. Tumbel1, Friska M. Montolalu1, Sandra A. Korua3, Franky R. Tulungen4

1Department of Pharmacy, Indonesia Christian University, Tomohon North Sulawesi, 95362, Indonesia
2Department of Biology, Indonesia Christian University, Tomohon North Sulawesi, 95362, Indonesia
3Department of Agrotechnology, Indonesia Christian University, Tomohon North Sulawesi, 95362, Indonesia
4Department of Agribusiness, Indonesia Christian University, Tomohon North Sulawesi, 95362, Indonesia


Corresponding Author: [email protected]; Tel: +62 852-4261-3749
Recieved Date: 06 September 2022; Accepted Date: 07 October 2022; Published Date: 01 November
Citation:
Maarisit W, Untu SD, Lengkey YK, Mongi J, Kanter JW, Pareta DN, Sambou CN, Tumbel SL, Montolalu FM, Korua SA, Tulungen FR. Isolation and Evaluation of Anti-Mycobacterial Activity of Alkaloid Compounds from Marine Invertebrate Sponge haliclona sp. J Nat Prod Res. 2022; 6(10):1622-1625. http://www.doi.org/10.26538/tjnpr/v6i10.10




http://www.doi.org/10.26538/tjnpr/v6i10.10
Copyright:
© 2022 Maarisit et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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ABSTRACT

Marine invertebrate sponges are a rich source of new bioactive substances. The objective of this investigation was to isolate the anti-mycobacterium bioactive compounds from sponge Haliclona sp. A new alkaloid (1) was obtained through bioassay-guided purification together with eight previously known substances, including cyclostellettamines A (5), B (6), C (7), E (8), and F (9) and the haliclocyclamines A (2), B (3), and C. The structures of 1-9 were established applying spectroscopic analysis, including 1D NMR (1H and 13C-NMR), 2D NMR (HMQC, HMBC, 1H-1H COSY), mass spectroscopy, IR, and UV. Furthermore, the findings revealed that the compounds exhibited inhibitory activity against Mycobacterium smegmatis at 10 µg/disc

Keywords: Antimycobacterial, Structure elucidation, Alkaloid, Natural product, Haliclona sp.
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ISSN: 2616-0684 (Print)
ISSN: 2616-0692 (Online)
DOI: 10.26538/tjnpr
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