Behavioral, Analgesic, Anti-Inflammatory and Acute Oral Toxicity Studies on Poly-Herbal Formulation with Anti-Oxidant and Anti-Cancer Effects

Farah-Saeed*, Hadiqa M. Akhtar, Usama Raza, Muhammad W. Ali, Habiba Nasir
Department of Pharmacognosy, Dow College of Pharmacy, Dow University of Health Sciences, Karachi-Pakistan
Corresponding Author: [email protected]; Tel: 0316-2534844
Recieved Date: 25 August 2022; Accepted Date: 04 October 2022; Published Date: 01 November
Citation:
Saeed F, Akhtar HM, Raza U, Ali MW, Nasir H. Behavioral, Analgesic, Anti-Inflammatory and Acute Oral Toxicity Studies on Poly-Herbal Formulation with Anti-Oxidant and Anti-Cancer Effects. Trop J Nat Prod Res. 2022; 6(10):1597-1601. http://www.doi.org/10.26538/tjnpr/v6i10.6


http://www.doi.org/10.26538/tjnpr/v6i10.6
Copyright:
© 2022 Saeed et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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ABSTRACT

The study was aimed at carrying out pre-clinical studies on the poly-herbal formulation having evidence-based anti-oxidant and anti-cancer properties. The study involved the following pre-clinical studies on the poly herbal drug: behavioral studies were carried out at doses 50 mg and 100 mg/kg respectively using open field and light and dark methods; analgesic activity based on acetic acid induced writhing test was performed at 50 mg and 100 mg/kg doses of the extract; anti-inflammatory activity of the poly-herbal extract was conducted at the following doses: 10, 50, 100, and 150 mg/ml.  Acute oral toxicity studies on the herbal extract were carried out at 5, 50, 300, 2000 and 5000 mg/kg doses. The results of pre-clinical studies carried out were comparable to the standards used endorsing the efficacy and safety of the herbal formulation under test. The efficacy and safety results of the activities carried out on the poly-herbal anti-oxidant and anti-cancer formulation by the researchers under test in this study and that of the already reported pharmacognostic, chemical, cytotoxic, anti-microbial and anti-oxidant results are suggestive of initiation of clinical studies on this supportive anti-oxidant and anti-cancer formulation.

Keywords: Analgesic activity, Anti-inflammatory, Light and dark test, Open field test, toxicity
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ISSN: 2616-0684 (Print)
ISSN: 2616-0692 (Online)
DOI: 10.26538/tjnpr
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