Sources, Structure, Synthesis and Biological Activities of Jatrophone: A Macrocyclic Diterpene

Khawlah Shari, Rania A. El Gedaily, Khaled M. Meselhy, Amal E. Khaleel, Essam Abdel-Sattar*
Pharmacognosy Department, Faculty of Pharmacy, Cairo University, Cairo 11562, Egypt

Corresponding Author: [email protected]; Tel: +6289501332718
Recieved Date: 12 October 2022; Accepted Date: 27 October 2022; Published Date: 01 November
Shari K, El Gedaily RA, Meselhy KM, Khaleel AE, Abdel-Sattar E. Sources, Structure, Synthesis and Biological Activities of Jatrophone: A Macrocyclic Diterpene. Trop J Nat Prod Res. 2022; 6(10):1576-1586.
© 2022 Shari et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Jatrophone (JAT) is a macrocyclic diterpene isolated from several Jatropha and Euphorbia species. Jatrophone and jatrophane derivatives are of wide interest because of their diverse biological and pharmacological activities. The goal of this article is to summarize the natural sources, synthesis, and biological activities of JAT.  This review was performed through a systematic search in electronic databases, for example, Egyptian Knowledge Bank databases (Web of Science, Scopus, and PubMed), and Google Scholar, covering the period from 1970 to February 2022.  A total of 788 articles were identified through Google Scholar, 92 in Scopus and 75 in Web of Science, and 32 in PubMed databases and after subsequent removal of duplication and irrelevant articles, resulted in 60 articles. The results revealed diverse biological activities for jatrophone such as inhibitory effects on insulin release, lymphocyte activation, and tumour cell proliferation. In addition, it showed relaxation of muscle contraction and rat portal vein, also, anti-protozoal, molluscicidal activities and gastroprotective effects. In conclusion, this review reported natural sources of JAT and explicated its wide biological activities thus suggesting that JAT is a potentially promising pharmacological candidate. However, more detailed safety and pharmacokinetic investigations are required.

Keywords: Euphorbiaceae, Jatrophone, Jatrophane Diterepene, Macrocyclic Diterpene, Biological Activities.
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ISSN: 2616-0684 (Print)
ISSN: 2616-0692 (Online)
DOI: 10.26538/tjnpr
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