Review of Isolation Methods, Chemical Composition and Biological Activities of Curcuma aeruginosa Roxb Rizhome

Ririn Suharsanti1,2, Puji Astuti3, Nunung Yuniarti4, Subagus Wahyuono3*
1Doctoral Program of Pharmaceutical Science, Faculty of Pharmacy, Universitas Gadjah Mada, Indonesia
2STIFAR “Yayasan Pharmasi”, Letjend Sarwo Edie Wibowo KM 1, Semarang, Indonesia
3Department of Pharmaceutical Biology, Faculty of Pharmacy, Universitas Gadjah Mada, Indonesia
4Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Gadjah Mada, Indonesia

Corresponding Author: [email protected]; Tel: +6281804374550
Recieved Date: 03 January 2022; Accepted Date: 05 October 2022; Published Date: 01 November
Suharsanti R, Astuti P, Yuniarti N, Wahyuono S. Review of Isolation Methods, Chemical Composition and Biological Activities of Curcuma aeruginosa Roxb Rizhome. Trop J Nat Prod Res. 2022;
© 2022 Suharsanti et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Curcuma aeruginosa Roxb rhizome is known as temu ireng or temu hitam in Indonesia and has been widely used as a traditional medicine in Asia. There have been many studies to reveal the chemical content of Curcuma aeruginosa Roxb rhizome, some of which are influenced by the isolation methods. Several separation and purification methods were identified including essential oil distillation, extraction and chromatography. This study aims to describe, analyze and discuss the isolation methods of chemicals compounds Curcuma aeruginosa Roxb rhizome, how the techniques influence the types and composition of the components and to examine which compounds have potential biological activities. The method used for review articles is explored several databases such as PubMed and Scopus to identify and download abstracts, original articles, and research papers related to extraction followed by fractionation, isolation, and chemical components of Curcuma aeruginosa Roxb. The inclusion criteria used were the article year between 2010-2020, the part used for the study was the rhizome, there was a discussion of isolation process, components that have been isolated and their biological activity. The exclusion criteria used were articles whose samples were only up to the extraction stage and articles whose methods were unclear. Chemical compounds of Curcuma aeruginosa Roxb rhizome can be carried out in various ways, including steam distillation, water distillation, extraction, fractionation to isolation by chromatography, especially column chromatography with elution gradient. Germacron is the most isolated and has several biological activities.

Keywords: Curcuma aeruginosa Roxb, Rhizome, Isolation, Chemical composition, biological activity.
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ISSN: 2616-0684 (Print)
ISSN: 2616-0692 (Online)
DOI: 10.26538/tjnpr
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