Cycloeucalenol and ?-Coumaric Acid from Nigerian Propolis and their Antimicrobial Activity

Sandra I. Iyen1,2, John V. Anyam2, John O. Igoli 2, Terrumun A. Tor-Anyiin2
1Department of Chemical Sciences, Federal University Wukari, Nigeria
2Department of Chemistry, Joseph Sarwuan Tarka University, Makurdi, Nigeria


Corresponding Author: [email protected]; Tel: +2348035232701
Recieved Date: 02 July 2022; Accepted Date: 25 August 2022; Published Date: 03 September
Citation: Iyen SI, Anyam JV, Igoli JO, Tor-Anyiin TA. Cycloeucalenol and Ρ-Coumaric Acid from Nigerian Propolis and their Antimicrobial Activity. Trop J Nat Prod Res. 2022; 6(8):1320-1325 http://www.doi.org/10.26538/tjnpr/v6i8.26
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© 2022 Iye et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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ABSTRACT

Propolis is a honeybee product employed in folkloric medicine and as a source of various bioactive constituents. Chromatography is a proven method for isolating natural compounds and the ethyl acetate extracts of propolis from Owerri in Imo State and Umuahia in Abia State Nigeria were subjected to column chromatography and the isolated compounds were identified by proton nuclear magnetic resonance (1H-NMR) analysis. The compounds isolated were cycloeucalenol and para-coumaric acid. Antimicrobial assay of the isolated compounds was carried out by agar well diffusion and broth dilution methods using local clinical isolates. The isolated compounds showed good antibacterial and antifungal activities with zones of inhibition ranging between 25-34 mm. The MIC/MBC/MFC values were between 5 mg/mL and 2.5 mg/mL. This study confirmed the folkloric use of propolis and its varying phytochemical composition.

Keywords: Nigerian propolis, Cycloeucalenol, Para-coumaric acid, 1H-NMR, Antimicrobial.
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ISSN: 2616-0684 (Print)
ISSN: 2616-0692 (Online)
DOI: 10.26538/tjnpr
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