In vitro Antifungal and In silico Antibacterial Evaluations of Anacardic Acid and its Complexes from Cashew Nut Shell Oil

David G. Oke1*, Esther O. Faboro1, Adesoji A. Olanrewaju1, Oluwatoba E. Oyeneyin2,3, Labunmi Lajide4

1Industrial Chemistry Programme, College of Agriculture, Science and Engineering, Bowen University, Iwo, Osun State, Nigeria
2Department of Chemical Sciences, Adekunle Ajasin University, Akungba-Akoko, Ondo state, Nigeria
3Theoretical and Computational Chemistry Unit, Adekunle Ajasin University, Akungba-Akoko, Ondo State, Nigeria
4Department of Chemistry, Federal University of Technology Akure, Ondo State, Nigeria

Corresponding Author: [email protected]; Tel: +2348063165709
Recieved Date: 15 June 2022; Accepted Date: 10 August 2022; Published Date: 03 September
Citation: Oke DG, Faboro EO, Olanrewaju AA, Oyeneyin OE, Lajide L. In vitro Antifungal and In silico Antibacterial Evaluations of Anacardic Acid and its Complexes from Cashew Nut Shell Oil. Trop J Nat Prod Res. 2022; 6(8):1290-1296.
© 2022 Oke et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Anacardic Acids (AcA) have been documented to have particularly important pathogenic properties. AcA and its complexes are being investigated in this article for their antimicrobial activities through in vitro and in silico assay methods. AcA from the cashew nut shell oil (CNSO) was isolated and Fourier-transform infrared spectroscopy (FTIR) and Proton nuclear magnetic resonance (1HNMR) were used to characterise the compound. AcA complexes were synthesised with hydrated metal (II) ions of Cobalt and Copper in a ratio of 1:1 using a modified method by Mendes et al. The antifungal activities of these AcA metal complexes were tested against five fungi. While AcA showed no antifungal activity, its complexes showed interesting results. Anacardic acid complex of cobalt (AcA-Co) showed activities against three of the five fungi; the best activity was against Penicillium citrinum (30±7.07 mm); a better result than clotrimazole (12.5±0.71 mm) which was the reference standard drug used. Anacardic acid complex of copper (AcA-Cu) also showed activities against all fungi tested against except Aspergillus flavus with the best activity also against Penicillium citrinum (15±2.83 mm). Standard precision (SP) and extra precision (XP) docking of AcA with 1Y54 revealed that it inhibits Enterococcus spp. better than standard drugs (Streptomycin and Tetracycline) as shown by docking scores and degree of binding affinities. These results of AcA and its complexes suggest additional studies which could lead to the development of new antifungal and antibacterial agents.

Keywords: Anacardic acid, Antibacterial, Antifungal, Anacardic acid complexes.
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ISSN: 2616-0684 (Print)
ISSN: 2616-0692 (Online)
DOI: 10.26538/tjnpr
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